Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Clinical use of trastuzumab combined with different chemotherapy regimens in multi‑line treatment of advanced human epidermal growth factor receptor 2‑positive gastric cancer: A case report

  • Authors:
    • Zhe‑Ling Chen
    • Andi Zhao
    • Pan Li
    • Mi Zhang
    • Jiao Yang
    • Lingxiao Zhang
    • Xiaoai Zhao
    • Jin Yang
    • Le Wang
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 4614-4620
    |
    Published online on: July 25, 2018
       https://doi.org/10.3892/ol.2018.9212
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

It is generally acknowledged that gastric cancer requires comprehensive treatment approaches to be adopted. For patients with human epidermal growth factor receptor‑2 (HER2)‑overexpressing gastric cancer, targeting HER2 with trastuzumab in first‑line therapy combined with standard chemotherapy significantly improves the prognosis. However, there is a lack of international guidance for second‑line treatment if a patient experiences disease progression. There is also no accepted conclusion regarding the efficiency of cross‑line therapy with trastuzumab. The present study reports the case of a 55‑year‑old male with gastric cancer who underwent radical gastrectomy. Immunohistochemistry indicated that samples were EGFR(+) and HER‑2(3+), with Ki‑67 (20%). From abdominal computed tomography scanning and contrast‑enhanced ultrasound following surgery, hepatic metastasis was identified and the patient was administered microwave thermocoagulation therapy. Since December 2012, the patient received multi‑line chemotherapy regimens as follows: i) Oxaliplatin, tegafur/gimeracil/oteracil and trastuzumab; ii) paclitaxel liposome and S‑1 plus trastuzumab; iii) apatinib; iv) epirubicin/oxaliplatin/xeloda; and v) irinotecan plus trastuzumab. During the course of therapy, the trastuzumab served an important function in multi‑line therapy and the patient benefited from the combined therapy. The application of trastuzumab in the multi‑line treatment of a patient with HER2‑positive advanced gastric cancer may be worthy of investigation for use in the clinic.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Zheng R, Zeng H, Zhang S and Chen W: Estimates of cancer incidence and mortality in China, 2013. Chin J Cancer. 36:662017. View Article : Google Scholar : PubMed/NCBI

3 

Fukushima R: Recent progress in the treatment of advanced gastric cancer. Nihon Geka Gakkai Zasshi. 113:32012.(In Japanese). PubMed/NCBI

4 

Xu JM: Comments on the seven clinical questions & answers in Japanese gastric treatment guidelines of the 4th edition. Zhonghua Zhong Liu Za Zhi (Chinese J Oncol). 39:236–238. 2017.

5 

Van Cutsem E, Bang YJ, Feng-Yi F, Xu JM, Lee KW, Jiao SC, Chong JL, López-Sanchez RI, Price T, Gladkov O, et al: HER2 screening data from ToGA: Targeting HER2 in gastric and gastroesophageal junction cancer. Gastric Cancer. 18:476–484. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Cho J, Jeong J, Sung J, Sung CO, Kim KM, Park CK, Choi MG, Sohn TS, Bae JM and Kim S: A large cohort of consecutive patients confirmed frequent HER2 positivity in gastric carcinomas with advanced stages. Ann Surg Oncol. 20 Suppl 3:S477–S484. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Kim KC, Koh YW, Chang HM, Kim TH, Yook JH, Kim BS, Jang SJ and Park YS: Evaluation of HER2 protein expression in gastric carcinomas: Comparative analysis of 1,414 cases of whole-tissue sections and 595 cases of tissue microarrays. Ann Surg Oncol. 18:2833–2840. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, et al: Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial. Lancet. 376:687–697. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Gong J, Liu T, Fan Q, Bai L, Bi F, Qin S, Wang J, Xu N, Cheng Y, Bai Y, et al: Optimal regimen of trastuzumab in combination with oxaliplatin/capecitabine in first-line treatment of HER2-positive advanced gastric cancer (CGOG1001): A multicenter, phase II trial. BMC Cancer. 16:682016. View Article : Google Scholar : PubMed/NCBI

10 

Chua C, Tan IB, Yamada Y, Rha SY, Yong WP, Ong WS, Tham CK, Ng M, Tai DW, Iwasa S, et al: Phase II study of trastuzumab in combination with S-1 and cisplatin in the first-line treatment of human epidermal growth factor receptor HER2-positive advanced gastric cancer. Cancer Chemother Pharmacol. 76:397–408. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Brower V: Apatinib in treatment of refractory gastric cancer. Lancet Oncol. 17:e1372016. View Article : Google Scholar : PubMed/NCBI

12 

Kang JH, Lee SI, Lim DH, Park KW, Oh SY, Kwon HC, Hwang IG, Lee SC, Nam E, Shin DB, et al: Salvage chemotherapy for pretreated gastric cancer: A randomized phase III trial comparing chemotherapy plus best supportive care with best supportive care alone. J Clin Oncol. 30:1513–1518. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Kang EJ, Im SA, Oh DY, Han SW, Kim JS, Choi IS, Kim JW, Kim YJ, Kim JH, Kim TY, et al: Irinotecan combined with 5-fluorouracil and leucovorin third-line chemotherapy after failure of fluoropyrimidine, platinum, and taxane in gastric cancer: Treatment outcomes and a prognostic model to predict survival. Gastric Cancer. 16:581–589. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Tarazona N, Smyth EC, Peckit C, Chau I, Watkins D, Rao S, Starling N and Cunningham D: Efficacy and toxicity of salvage weekly paclitaxel chemotherapy in non-Asian patients with advanced oesophagogastric adenocarcinoma. Ther Adv Med Oncol. 8:104–112. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Guideline Recommendations for HER2 Detection in Gastric Cancer Group: Guidelines for HER2 detection in gastric cancer (2016). Zhonghua Bing Li Xue Za Zhi. 45:528–532. 2016.PubMed/NCBI

16 

Guideline Recommendations for HER2 Detection in Gastric Cancer Group: Guidelines for HER2 detection in gastric cancer. Zhonghua Bing Li Xue Za Zhi. 40:553–557. 2011.PubMed/NCBI

17 

Lei YY, Huang JY, Zhao QR, Jiang N, Xu HM, Wang ZN, Li HQ, Zhang SB and Sun Z: The clinicopathological parameters and prognostic significance of HER2 expression in gastric cancer patients: A meta-analysis of literature. World J Surg Oncol. 15:682017. View Article : Google Scholar : PubMed/NCBI

18 

Kurokawa Y, Sugimoto N, Miwa H, Tsuda M, Nishina S, Okuda H, Imamura H, Gamoh M, Sakai D, Shimokawa T, et al: Phase II study of trastuzumab in combination with S-1 plus cisplatin in HER2-positive gastric cancer (HERBIS-1). Br J Cancer. 110:1163–1168. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Ryu MH, Yoo C, Kim JG, Ryoo BY, Park YS, Park SR, Han HS, Chung IJ, Song EK, Lee KH, et al: Multicenter phase II study of trastuzumab in combination with capecitabine and oxaliplatin for advanced gastric cancer. Eur J Cancer. 51:482–488. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Fang FQ: A clinical study of DOF regimenvsSOX regimen as first-line treatment in patients with advanced gastric carcinoma. World Chin J Digestol. 22:48302014. View Article : Google Scholar

21 

Cunningham D, Okines AF and Ashley S: Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med. 362:858–859. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Hironaka S, Ueda S, Yasui H, Nishina T, Tsuda M, Tsumura T, Sugimoto N, Shimodaira H, Tokunaga S, Moriwaki T, et al: Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum: WJOG 4007 trial. J Clin Oncol. 31:4438–4444. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Meads DM, Marshall A, Hulme CT, Dunn JA and Ford HE: The cost effectiveness of docetaxel and active symptom control versus active symptom control alone for refractory oesophagogastric adenocarcinoma: Economic analysis of the COUGAR-02 trial. PharmacoEconomics. 34:33–42. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Ajani JA, D'Amico TA, Almhanna K, Bentrem DJ, Chao J, Das P, Denlinger CS, Fanta P, Farjah F, Fuchs CS, et al: Gastric cancer, version 3.2016, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Netw. 14:1286–1312. 2016. View Article : Google Scholar

25 

Nishikawa K, Takahashi T, Takaishi H, Miki A, Noshiro H, Yoshikawa T, Nishida Y, Iwasa S, Miwa H, Masuishi T, et al: Phase II study of the effectiveness and safety of trastuzumab and paclitaxel for taxane- and trastuzumab-naive patients with HER2-positive, previously treated, advanced, or recurrent gastric cancer (JFMC45-1102). Int J Cancer. 140:188–196. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Ford HE, Marshall A, Bridgewater JA, Janowitz T, Coxon FY, Wadsley J, Mansoor W, Fyfe D, Madhusudan S, Middleton GW, et al: Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): An open-label, phase 3 randomised controlled trial. Lancet Oncol. 15:78–86. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Thuss-Patience PC, Kretzschmar A, Bichev D, Deist T, Hinke A, Breithaupt K, Dogan Y, Gebauer B, Schumacher G and Reichardt P: Survival advantage for irinotecan versus best supportive care as second-line chemotherapy in gastric cancer-a randomised phase III study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Eur J Cancer. 47:2306–2314. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Sym SJ, Hong J, Park J, Cho EK, Lee JH, Park YH, Lee WK, Chung M, Kim HS, Park SH and Shin DB: A randomized phase II study of biweekly irinotecan monotherapy or a combination of irinotecan plus 5-fluorouracil/leucovorin (mFOLFIRI) in patients with metastatic gastric adenocarcinoma refractory to or progressive after first-line chemotherapy. Cancer Chemother Pharmacol. 71:481–488. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Maruta F, Ishizone S, Hiraguri M, Fujimori Y, Shimizu F, Kumeda S and Miyagawa S: A clinical study of docetaxel with or without 5′DFUR as a second-line chemotherapy for advanced gastric cancer. Med Oncol. 24:71–75. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Satoh T, Xu RH, Chung HC, Sun GP, Doi T, Xu JM, Tsuji A, Omuro Y, Li J, Wang JW, et al: Lapatinib plus paclitaxel versus paclitaxel alone in the second-line treatment of HER2-amplified advanced gastric cancer in Asian populations: TyTAN-a randomized, phase III study. J Clin Oncol. 32:2039–2049. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Chen SC, Kagedal M, Gao Y, Wang B, Harle-Yge ML, Girish S, Jin J and Li C: Population pharmacokinetics of trastuzumab emtansine in previously treated patients with HER2-positive advanced gastric cancer (AGC). Cancer Chemother Pharmacol. 80:1147–1159. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Fuchs CS, Tomasek J, Yong CJ, Dumitru F, Passalacqua R, Goswami C, Safran H, Dos Santos LV, Aprile G, Ferry DR, et al: Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): An international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet. 383:31–39. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Wilke H, Muro K, Van Cutsem E, Oh SC, Bodoky G, Shimada Y, Hironaka S, Sugimoto N, Lipatov O, Kim TY, et al: Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): A double-blind, randomised phase 3 trial. Lancet Oncol. 15:1224–1235. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Yuan M, Shi Z, Wang Z, Lv W, Yang Y, Lu F, Zhao Y and Zhong H: The significance of multi-line chemotherapy for advanced gastric cancer: A retrospective analysis. Mol Clin Oncol. 6:606–612. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Zhang W, Yu Y, Fang Y, Wang Y, Cui Y, Shen K and Liu T: Systemic chemotherapy as a main strategy for liver metastases from gastric cancer. Clin Transl Oncol. 17:888–894. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Li J, Qin S, Xu J, Xiong J, Wu C, Bai Y, Liu W, Tong J, Liu Y, Xu R, et al: Randomized, double-blind, placebo-controlled phase iii trial of apatinib in patients with chemotherapy-refractory advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction. J Clin Oncol. 34:1448–1454. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Moore KN, Martin LP, O'Malley DM, Matulonis UA, Konner JA, Perez RP, Bauer TM, Ruiz-Soto R and Birrer MJ: Safety and activity of mirvetuximab soravtansine (IMGN853), a folate receptor alpha-targeting antibody-drug conjugate, in platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer: A phase I expansion study. J Clin Oncol. 35:1112–1118. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Yamasaki M, Saito N, Hada Y, Miyamoto S, Okanobu H, Ikeda N, Daido W, Ishiyama S, Deguchi N, Taniwaki M and Ohashi N: Nivolumab therapy for synchronous ALK-positive lung cancer and gastric cancer. Case Rep Oncol. 10:361–367. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen ZL, Zhao A, Li P, Zhang M, Yang J, Zhang L, Zhao X, Yang J and Wang L: Clinical use of trastuzumab combined with different chemotherapy regimens in multi‑line treatment of advanced human epidermal growth factor receptor 2‑positive gastric cancer: A case report. Oncol Lett 16: 4614-4620, 2018.
APA
Chen, Z., Zhao, A., Li, P., Zhang, M., Yang, J., Zhang, L. ... Wang, L. (2018). Clinical use of trastuzumab combined with different chemotherapy regimens in multi‑line treatment of advanced human epidermal growth factor receptor 2‑positive gastric cancer: A case report. Oncology Letters, 16, 4614-4620. https://doi.org/10.3892/ol.2018.9212
MLA
Chen, Z., Zhao, A., Li, P., Zhang, M., Yang, J., Zhang, L., Zhao, X., Yang, J., Wang, L."Clinical use of trastuzumab combined with different chemotherapy regimens in multi‑line treatment of advanced human epidermal growth factor receptor 2‑positive gastric cancer: A case report". Oncology Letters 16.4 (2018): 4614-4620.
Chicago
Chen, Z., Zhao, A., Li, P., Zhang, M., Yang, J., Zhang, L., Zhao, X., Yang, J., Wang, L."Clinical use of trastuzumab combined with different chemotherapy regimens in multi‑line treatment of advanced human epidermal growth factor receptor 2‑positive gastric cancer: A case report". Oncology Letters 16, no. 4 (2018): 4614-4620. https://doi.org/10.3892/ol.2018.9212
Copy and paste a formatted citation
x
Spandidos Publications style
Chen ZL, Zhao A, Li P, Zhang M, Yang J, Zhang L, Zhao X, Yang J and Wang L: Clinical use of trastuzumab combined with different chemotherapy regimens in multi‑line treatment of advanced human epidermal growth factor receptor 2‑positive gastric cancer: A case report. Oncol Lett 16: 4614-4620, 2018.
APA
Chen, Z., Zhao, A., Li, P., Zhang, M., Yang, J., Zhang, L. ... Wang, L. (2018). Clinical use of trastuzumab combined with different chemotherapy regimens in multi‑line treatment of advanced human epidermal growth factor receptor 2‑positive gastric cancer: A case report. Oncology Letters, 16, 4614-4620. https://doi.org/10.3892/ol.2018.9212
MLA
Chen, Z., Zhao, A., Li, P., Zhang, M., Yang, J., Zhang, L., Zhao, X., Yang, J., Wang, L."Clinical use of trastuzumab combined with different chemotherapy regimens in multi‑line treatment of advanced human epidermal growth factor receptor 2‑positive gastric cancer: A case report". Oncology Letters 16.4 (2018): 4614-4620.
Chicago
Chen, Z., Zhao, A., Li, P., Zhang, M., Yang, J., Zhang, L., Zhao, X., Yang, J., Wang, L."Clinical use of trastuzumab combined with different chemotherapy regimens in multi‑line treatment of advanced human epidermal growth factor receptor 2‑positive gastric cancer: A case report". Oncology Letters 16, no. 4 (2018): 4614-4620. https://doi.org/10.3892/ol.2018.9212
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team