Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Spindle cell melanoma: Incidence and survival, 1973‑2017

  • Authors:
    • Zhe Xu
    • Ping Shi
    • Feiluore Yibulayin
    • Lei Feng
    • Hao Zhang
    • Alimujiang Wushou
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Shenzhen Longhua District Central Hospital, Guangdong Medical University, Shenzhen, Guangdong 518110, P.R. China, Department of Oral and Maxillofacial Surgery, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, P.R. China, Department of Oral Biomedical Engineering Laboratory, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5091-5099
    |
    Published online on: August 1, 2018
       https://doi.org/10.3892/ol.2018.9247
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Spindle cell melanoma (SCM) is a rare morphological subtype of melanoma, which is relatively uncharacterized. The aim of the present study was to investigate the incidence of SCM, its general demographics, basic clinico‑pathologic features, treatment outcomes and disease‑specific prognostic factors. SCM cases were sampled from the Surveillance, Epidemiology and End Results (SEER) Program (1973‑2017). A total of 4761 SCM cases were identified, with a median age of 66 years. The female:male ratio was 0.62:1. Statistically significant overall survival (OS) and disease‑specific survival (DSS) rate differences were identified depending on age, sex, ethnicity, tumor location, T stage, N stage, M stage, pathological grade, AJCC stage, SEER stages and surgical treatment (P<0.05). Multivariate Cox regression analysis revealed that age >66 years, T3+T4 stage disease, positive N stage and SEER historic stage of regional and distant metastasis tumor were associated with poor DSS and OS rates. In summary, SCM was most common in Caucasian people of 60~80 years of age with a predominance in males. Patient's age, ethnicity, T stage, N stage, and SEER historic stage were identified as independent prognostic factors of SCM in terms of DSS and OS.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Winnepenninckx V, De Vos R, Stas M and van den Oord JJ: New phenotypical and ultrastructural findings in spindle cell (desmoplastic/neurotropic) melanoma. Appl Immunohistochem Mol Morphol. 11:319–325. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Diaz A, Valera A, Carrera C, Hakim S, Aguilera P, García A, Palou J, Puig S, Malvehy J and Alos L: Pigmented spindle cell nevus: Clues for differentiating it from spindle cell malignant melanoma. A comprehensive survey including clinicopathologic, immunohistochemical, and FISH studies. Am J Surg Pathol. 35:1733–1742. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Dainichi T, Kobayashi C, Fujita S, Shiramizu K, Ishiko T, Kiryu H, Urabe K, Tsuneyoshi M and Furue M: Interdigital amelanotic spindle-cell melanoma mimicking an inflammatory process due to dermatophytosis. J Dermatol. 34:716–719. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Sheff JS and Pane TA: Spindle cell melanoma arising from decades-old burn scar. Plast Reconstr Surg. 124:274e–275e. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Jackson CR, Minca EC, Kapil JP, Smith SC and Billings SD: Superficial malignant peripheral nerve sheath tumor with overlying intradermal melanocytic nevus mimicking spindle cell melanoma. J Cutan Pathol. 43:1220–1225. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Walia R, Jain D, Mathur SR and Iyer VK: Spindle cell melanoma: A comparison of the cytomorphological features with the epithelioid variant. Acta Cytol. 57:557–561. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Falconieri G, Bacchi CE and Luzar B: Cutaneous clear cell sarcoma: Report of three cases of a potentially underestimated mimicker of spindle cell melanoma. Am J Dermatopathol. 34:619–625. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Yeh I, Vemula SS, Mirza SA and McCalmont TH: Neurofibroma-like spindle cell melanoma: CD34 fingerprint and CGH for diagnosis. Am J Dermatopathol. 34:668–670. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Tacha D, Qi W, Ra S, Bremer R, Yu C, Chu J, Hoang L and Robbins B: A newly developed mouse monoclonal SOX10 antibody is a highly sensitive and specific marker for malignant melanoma, including spindle cell and desmoplastic melanomas. Arch Pathol Lab Med. 139:530–536. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Weissinger SE, Keil P, Silvers DN, Klaus BM, Möller P, Horst BA and Lennerz JK: A diagnostic algorithm to distinguish desmoplastic from spindle cell melanoma. Mod Pathol. 27:524–534. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Stowman AM, Mills SE and Wick MR: Spindle cell melanoma and interdigitating dendritic cell sarcoma: Do they represent the same process? Am J Surg Pathol. 40:1270–1279. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Rawandale NA and Suryawanshi KH: Primary spindle cell malignant melanoma of esophagus: An unusual finding. J Clin Diagn Res. 10:OD03–OD04. 2016.PubMed/NCBI

13 

Sundersingh S, Majhi U, Narayanaswamy K and Balasubramanian S: Primary spindle cell melanoma of the urinary bladder. Indian J Pathol Microbiol. 54:422–424. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Agostini P, Rivero A, Parra Martin JA and Soares-de-Almeida L: Pedunculated polypoid melanoma. A case report of a rare spindle-cell variant of melanoma. Dermatol Online J J. 21:pii2015.

15 

Piao Y, Guo M and Gong Y: Diagnostic challenges of metastatic spindle cell melanoma on fine-needle aspiration specimens. Cancer. 114:94–101. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Fritz A, Percy C and Jack A: International classification of diseases for oncology: ICD-O-3. World Health Organization; 2000

17 

Elder DE: Pathological staging of melanoma. Methods Mol Biol. 1102:325–351. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Murali R, Doubrovsky A, Watson GF, McKenzie PR, Lee CS, McLeod DJ, Uren RF, Stretch JR, Saw RP, Thompson JF and Scolyer RA: Diagnosis of metastatic melanoma by fine-needle biopsy: Analysis of 2,204 cases. Am J Clin Pathol. 127:385–397. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Gupta SK, Rajwanshi AK and Das DK: Fine needle aspiration cytology smear patterns of malignant melanoma. Acta Cytol. 29:983–988. 1985.PubMed/NCBI

20 

Soengas MS and Patton EE: Location, Location, Location: Spatio-temporal cues that define the cell of origin in melanoma. Cell Stem Cell. 21:559–561. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Kim J, Lazar AJ, Davies MA, Homsi J, Papadopoulos NE, Hwu WJ, Bedikian AY, Woodman SE, Patel SP, Hwu P and Kim KB: BRAF, NRAS and KIT sequencing analysis of spindle cell melanoma. J Cutan Pathol. 39:821–825. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Hernando B, Ibarrola-Villava M, Fernandez LP, Peña-Chilet M, Llorca-Cardeñosa M, Oltra SS, Alonso S, Boyano MD, Martinez-Cadenas C and Ribas G: Sex-specific genetic effects associated with pigmentation, sensitivity to sunlight, and melanoma in a population of Spanish origin. Biol Sex Differ. 7:172016. View Article : Google Scholar : PubMed/NCBI

23 

Voinea S, Blidaru A, Panaitescu E and Sandru A: Impact of gender and primary tumor location on outcome of patients with cutaneous melanoma. J Med Life. 9:444–448. 2016.PubMed/NCBI

24 

Kadakia S, Chan D, Mourad M and Ducic Y: The prognostic value of age, sex, and subsite in cutaneous head and neck melanoma: A clinical review of recent literature. Iran J Cancer Prev. 9:e50792016.PubMed/NCBI

25 

Balch CM, Soong SJ, Gershenwald JE, Thompson JF, Coit DG, Atkins MB, Ding S, Cochran AJ, Eggermont AM, Flaherty KT, et al: Age as a prognostic factor in patients with localized melanoma and regional metastases. Ann Surg Oncol. 20:3961–3968. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Stokes WA and Lentsch EJ: Age is an independent poor prognostic factor in cutaneous head and neck melanoma. Laryngoscope. 124:462–465. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Arce PM, Camilon PR, Stokes WA, Nguyen SA and Lentsch EJ: Is sex an independent prognostic factor in cutaneous head and neck melanoma? Laryngoscope. 124:1363–1367. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Kobayashi G and Cobb C: A case of amelanotic spindle-cell melanoma presenting as metastases to breast and axillary lymph node: Diagnosis by FNA cytology. Diagn Cytopathol. 22:246–249. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Lindsey KG, Ingram C, Bergeron J and Yang J: Cytological diagnosis of metastatic malignant melanoma by fine-needle aspiration biopsy. Semin Diagn Pathol. 33:198–203. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Mayayo Artal E, Gomez-Aracil V, Mayayo Alvira R, Azua-Romeo J and Arraiza A: Spindle cell malignant melanoma metastatic to the breast from a pigmented lesion on the back. A case report. Acta Cytol. 48:387–390. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Arora SK, Gupta N, Kang M and Rajwanshi A: Fine-needle aspiration cytology in a case of metastatic spindle cell melanoma in liver. Diagn Cytopathol. 38:425–426. 2010.PubMed/NCBI

32 

Santeusanio G, Ventura L, Mauriello A, Carosi M, Spagnoli LG, Maturo P, Terranova L and Romanini C: Isolated ovarian metastasis from a spindle cell malignant melanoma of the choroid 14 years after enucleation: Prognostic implication of the keratin immunophenotype. Appl Immunohistochem Mol Morphol. 8:329–333. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Gladfelter P, Darwish NHE and Mousa SA: Current status and future direction in the management of malignant melanoma. Melanoma Res. 27:403–410. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu Z, Shi P, Yibulayin F, Feng L, Zhang H and Wushou A: Spindle cell melanoma: Incidence and survival, 1973‑2017. Oncol Lett 16: 5091-5099, 2018.
APA
Xu, Z., Shi, P., Yibulayin, F., Feng, L., Zhang, H., & Wushou, A. (2018). Spindle cell melanoma: Incidence and survival, 1973‑2017. Oncology Letters, 16, 5091-5099. https://doi.org/10.3892/ol.2018.9247
MLA
Xu, Z., Shi, P., Yibulayin, F., Feng, L., Zhang, H., Wushou, A."Spindle cell melanoma: Incidence and survival, 1973‑2017". Oncology Letters 16.4 (2018): 5091-5099.
Chicago
Xu, Z., Shi, P., Yibulayin, F., Feng, L., Zhang, H., Wushou, A."Spindle cell melanoma: Incidence and survival, 1973‑2017". Oncology Letters 16, no. 4 (2018): 5091-5099. https://doi.org/10.3892/ol.2018.9247
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Z, Shi P, Yibulayin F, Feng L, Zhang H and Wushou A: Spindle cell melanoma: Incidence and survival, 1973‑2017. Oncol Lett 16: 5091-5099, 2018.
APA
Xu, Z., Shi, P., Yibulayin, F., Feng, L., Zhang, H., & Wushou, A. (2018). Spindle cell melanoma: Incidence and survival, 1973‑2017. Oncology Letters, 16, 5091-5099. https://doi.org/10.3892/ol.2018.9247
MLA
Xu, Z., Shi, P., Yibulayin, F., Feng, L., Zhang, H., Wushou, A."Spindle cell melanoma: Incidence and survival, 1973‑2017". Oncology Letters 16.4 (2018): 5091-5099.
Chicago
Xu, Z., Shi, P., Yibulayin, F., Feng, L., Zhang, H., Wushou, A."Spindle cell melanoma: Incidence and survival, 1973‑2017". Oncology Letters 16, no. 4 (2018): 5091-5099. https://doi.org/10.3892/ol.2018.9247
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team