Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Caveolin‑1 facilitated KCNA5 expression, promoting breast cancer viability

  • Authors:
    • Chao Qu
    • Jia Sun
    • Ying Liu
    • Xiaobo Wang
    • Lifen Wang
    • Chao Han
    • Qian Chen
    • Tianhui Guan
    • Hongyan Li
    • Yejun Zhang
    • Yang Wang
    • Jia Liu
    • Wei Zou
    • Jing Liu
  • View Affiliations / Copyright

    Affiliations: College of Life Science, Liaoning Normal University, Dalian, Liaoning 116029, P.R. China, No. 210 Hospital of Chinese People's Liberation Army, Dalian, Liaoning 116021, P.R. China, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China, Centre for Regenerative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116085, P.R. China
    Copyright: © Qu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4829-4838
    |
    Published online on: August 3, 2018
       https://doi.org/10.3892/ol.2018.9261
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Potassium voltage‑gated channel subfamily A member 5 (KCNA5) is a voltage‑gated potassium channel protein encoded by the KCNA5 gene. A large number of studies have shown that KCNA5 is associated with the survival of malignant tumors, including breast cancer, but the detailed mechanism remains inconclusive. Our previous study found that KCNA5 is co‑expressed with a scaffolding protein, caveolin‑1 in MCF‑10A‑neoT non‑tumorigenic epithelial cell. In the present study, KCNA5 and caveolin‑1 were expressed in breast cancer tissues and cell lines. Exposing MCF‑10A‑neoT to 2 mM of methyl‑β‑cyclodextrin, an agent to disrupt caveolae and lipid rafts led to a downregulation of caveolin‑1 that reduced the expression of KCNA5. Furthermore, following caveolin‑1 knockdown, the expression of KCNA5 was decreased in MDA‑MB‑231 human breast cancer and MCF‑10A‑neoT non‑tumorigenic epithelial cell lines. In subsequent experiments, the MTT assay showed that increased caveolin‑1 and KCNA5 expression promoted the survival of MCF‑7 human breast cancer cells, but cell survival was not affected following KCNA5 overexpression alone. Using small interfering RNA technology, KCNA5‑silenced MCF‑10A‑neoT cells were established and a decreased level of phosphorylated‑AKT serine/threonine kinase (AKT) was observed in the cells compared with the parental cells. Overall, these results suggested that caveolin‑1 facilitated KCNA5 expression and may be associated with AKT activation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Wulff H, Castle NA and Pardo LA: Voltage-gated potassium channels as therapeutic targets. Nat Rev Drug Discov. 8:982–1001. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Kunzelmann K: Ion channels and cancer. J Membr Biol. 205:159–173. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Lee JH, Park JW, Byun JK, Kim HK, Ryu PD, Lee SY and Kim DY: Silencing of voltage-gated potassium channel KV9.3 inhibits proliferation in human colon and lung carcinoma cells. Oncotarget. 6:8132–8143. 2015.PubMed/NCBI

4 

Delgado-Ramírez M, Morán-Zendejas R, Aréchiga-Figueroa IA, Toro-Castillo C, Ramírez-Martínez JF and Rodríguez-Menchaca AA: Modulation of the voltage-gated potassium channel Kv2.1 by the anti-tumor alkylphospholipid perifosine. Pharmacol Rep. 68:457–461. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Tegla CA, Cudrici C, Rozycka M, Soloviova K, Ito T, Singh AK, Khan A, Azimzadeh P, Andrian-Albescu M, Khan A, et al: C5b-9-activated, K(v)1.3 channels mediate oligodendrocyte cell cycle activation and dedifferentiation. Exp Mol Pathol. 91:335–345. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Kazama I, Baba A, Matsubara M, Endo Y, Toyama H and Ejima Y: Benidipine suppresses in situ proliferation of leukocytes and slows the progression of renal fibrosis in rat kidneys with advanced chronic renal failure. Nephron Exp Nephrol. 128:67–79. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Liu J, Feng S, Zhang L, Wu Z, Chen Q, Cheng W, Wang SQ and Zou W: Expression and properties of potassium channels in human mammary epithelial cell line MCF10A and its possible role in proliferation. Sheng Li Xue Bao. 62:203–209. 2010.(In Chinese). PubMed/NCBI

8 

Ru Q, Tian X, Wu YX, Wu RH, Pi MS and Li CY: Voltage-gated and ATP-sensitive K+ channels are associated with cell proliferation and tumorigenesis of human glioma. Oncol Rep. 31:842–848. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Pincus DW, DiCicco-Bloom E and Black IB: Role of voltage-sensitive calcium channels in mitogenic stimulation of neuroblasts. Brain Res. 553:211–214. 1991. View Article : Google Scholar : PubMed/NCBI

10 

Wei T, Liang Z, Jin Y and Zhang L: Effect of berberine, liensinine and neferine on HERG channel expression. Zhongguo Zhong Yao Za Zhi. 38:239–244. 2013.(In Chinese). PubMed/NCBI

11 

Zhu YX, Yin H, Bruins LA, Shi CX, Jedlowski P, Aziz M, Sereduk C, Kortuem KM, Schmidt JE, Champion M, et al: RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2. Blood. 125:483–491. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Guo TB, Lu J, Li T, Lu Z, Xu G, Xu M, Lu L and Dai W: Insulin-activated, K+-channel-sensitive Akt pathway is primary mediator of ML-1 cell proliferation. Am J Physiol Cell Physiol. 289:C257–C263. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Roderick C, Reinach PS, Wang L and Lu L: Modulation of rabbit corneal epithelial cell proliferation by growth factor-regulated K(+) channel activity. J Membr Biol. 196:41–50. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Ballou LM, Lin RZ and Cohen IS: Control of cardiac repolarization by phosphoinositide 3-kinase signaling to ion channels. Circ Res. 116:127–137. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Shepherd AJ, Loo L and Mohapatra DP: Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure. PLoS One. 8:e766982013. View Article : Google Scholar : PubMed/NCBI

16 

Harder T and Simons K: Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains. Curr Opin Cell Biol. 9:534–542. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Takaguri A, Kamato M, Satoh Y, Ohtsuki K and Satoh K: Effect of alteration of caveolin-1 expression on doxorubicin-induced apoptosis in H9c2 cardiac cells. Cell Biol Int. 39:1053–1060. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Banadakoppa M, Goluszko P, Liebenthal D and Yallampalli C: Nitric oxide induces segregation of decay accelerating factor (DAF or CD55) from the membrane lipid-rafts and its internalization in human endometrial cells. Cell Biol Int. 36:901–907. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Takaguri A, Kamato M, Satoh Y, Ohtsuki K and Satoh K: Effect of alteration of caveolin-1 expression on doxorubicin-induced apoptosis in H9c2 cardiac cells. Cell Biol Int. 39:1053–1060. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Cheng ZJ, Singh RD, Marks DL and Pagano RE: Membrane microdomains, caveolae, and caveolar endocytosis of sphingolipids. Mol Membr Biol. 23:101–110. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Parton RG and Simons K: The multiple faces of caveolae. Nat Rev Mol Cell Biol. 8:185–194. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Lapierre LA, Ducharme NA, Drake KR, Goldenring JR and Kenworthy AK: Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial cells. Exp Cell Res. 318:103–113. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Shvets E, Ludwig A and Nichols BJ: News from the caves: Update on the structure and function of caveolae. Curr Opin Cell Biol. 29:99–106. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Thomas CM and Smart EJ: Caveolae structure and function. J Cell Mol Med. 12:796–809. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Thompson MA, Prakash YS and Pabelick CM: The role of caveolae in the pathophysiology of lung diseases. Expert Rev Respir Med. 8:111–122. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Chaudhary KR, Cho WJ, Yang F, Samokhvalov V, El-Sikhry HE, Daniel EE and Seubert JM: Effect of ischemia reperfusion injury and epoxyeicosatrienoic acids on caveolin expression in mouse myocardium. J Cardiovasc Pharmacol. 61:258–263. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Martens JR, Sakamoto N, Sullivan SA, Grobaski TD and Tamkun MM: Isoform-specific localization of voltage-gated K+ channels to distinct lipid raft populations. Targeting of Kv1.5 to caveolae. J Biol Chem. 276:8409–8414. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Cogolludo A, Moreno L, Lodi F, Frazziano G, Cobeño L, Tamargo J and Perez-Vizcaino F: Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: Role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization. Circ Res. 98:931–938. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Brignell JL, Perry MD, Nelson CP, Willets JM, Challiss RA and Davies NW: Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B. PLoS One. 10:e01212852015. View Article : Google Scholar : PubMed/NCBI

30 

Brazer SC, Singh BB, Liu X, Swaim W and Ambudkar IS: Caveolin-1 contributes to assembly of store-operated Ca2+ influx channels by regulating plasma membrane localization of TRPC1. J Biol Chem. 278:27208–27215. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Anderson RG: The caveolae membrane system. Annu Rev Biochem. 67:199–225. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Okamoto T, Schlegel A, Scherer PE and Lisanti MP: Caveolins, a family of scaffolding proteins for organizing ‘preassembled signaling complexes’ at the plasma membrane. J Biol Chem. 273:5419–5422. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Overmiller AM, McGuinn KP, Roberts BJ, Cooper F, Brennan-Crispi DM, Deguchi T, Peltonen S, Wahl JK II and Mahoney MG: c-Src/Cav-1-dependent activation of the EGFR by Dsg2. Oncotarget. 7:37536–37555. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Feng S, Wang Y, Wang X, Wang Z, Cui Y, Liu J, Zhao C, Jin M and Zou W: Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Eralpha36 and the transformation of MCF10ACE. Sci China Life Sci. 53:598–605. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Wang X, Feng S, Zhang H, Wang Y, Cui Y, Wang Z, Liu J and Zou W: RNA inference-mediated caveolin-1 downregulation decrease estrogen receptor alpha (ERα) signaling in human mammary epithelial cells. Mol Biol Rep. 38:761–768. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Liu J, Qu C, Li H, Zhang Y, Sun J, Yang S, Liu J, An L and Zou W: Expression of KCNA5 protein in human mammary epithelial cell line associated with caveolin-1. J Membr Biol. 249:449–457. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Qu C, Fu XZ, Han C, Chen Q, Liu Y, Wang Xb, Xi RG, Liu J and Zou W: Voltage-gated potassium channel KV1.5 protects against MPP+ mediated neurotoxicity in PC12 cells. Adv Biochem. 2:103–108. 2014. View Article : Google Scholar

38 

Abdul M, Santo A and Hoosein N: Activity of potassium channel-blockers in breast cancer. Anticancer Res. 23:3347–3351. 2003.PubMed/NCBI

39 

Zou W, Zhang L, Wang X and Zhou SS: Effect of potassium channel antagonist on proliferation in the human mammary epithelial cells MCF10A. J Liao Ning Norm Univ. 31:23–26. 2008.

40 

Wonderlin WF and Strobl JS: Potassium channels, proliferation and G1 progression. J Membr Biol. 154:91–107. 1996. View Article : Google Scholar : PubMed/NCBI

41 

El-Kholy W, Macdonald PE, Lin JH, Wang J, Fox JM, Light PE, Wang Q, Tsushima RG and Wheeler MB: The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J. 17:720–722. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Nauc V, De Lamirande E, Leclerc P and Gagnon C: Inhibitors of phosphoinositide 3-kinase, LY294002 and wortmannin, affect sperm capacitation and associated phosphorylation of proteins differently: Ca2+-dependent divergences. J Androl. 25:573–585. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Cipriani P, Di Benedetto P, Capece D, Zazzeroni F, Liakouli V, Ruscitti P, Pantano I, Berardicurti O, Carubbi F, Alesse E and Giacomelli R: Impaired Cav-1 expression in SSc mesenchymal cells upregulates VEGF signaling: A link between vascular involvement and fibrosis. Fibrogenesis Tissue Repair. 7:132014. View Article : Google Scholar : PubMed/NCBI

44 

Sottile J and Chandler J: Fibronectin matrix turnover occurs through a caveolin-1-dependent process. Mol Biol Cell. 16:757–768. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Martens JR, Navarro-Polanco R, Coppock EA, Nishiyama A, Parshley L, Grobaski TD and Tamkun MM: Differential targeting of Shaker-like potassium channels to lipid rafts. J Biol Chem. 275:7443–7446. 2000. View Article : Google Scholar : PubMed/NCBI

46 

Markandeya YS, Phelan LJ, Woon MT, Keefe AM, Reynolds CR, August BK, Hacker TA, Roth DM, Patel HH and Balijepalli RC: Caveolin-3 overexpression attenuates cardiac hypertrophy via inhibition of T-type Ca2+ current modulated by protein kinase cα in cardiomyocytes. J Biol Chem. 290:22085–22100. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Schilling JM, Horikawa YT, Zemljic-Harpf AE, Vincent KP, Tyan L, Yu JK, McCulloch AD, Balijepalli RC, Patel HH and Roth DM: Electrophysiology and metabolism of caveolin-3-overexpressing mice. Basic Res Cardiol. 111:282016. View Article : Google Scholar : PubMed/NCBI

48 

Vicente R, Villalonga N, Calvo M, Escalada A, Solsona C, Soler C, Tamkun MM and Felipe A: Kv1.5 association modifies Kv1.3 traffic and membrane localization. J Biol Chem. 283:8756–8764. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Pérez-Verdaguer M, Capera J, Martínez-Mármol R, Camps M, Comes N, Tamkun MM and Felipe A: Caveolin interaction governs Kv1.3 lipid raft targeting. Sci Rep. 6:224532016. View Article : Google Scholar : PubMed/NCBI

50 

Zou W, Mcdaneld L and Smith LM: Caveolin 1 haploinsufficiency leads to partial transformation of human breast epithelial cells. Anticancer Res. 23:4581–4586. 2003.PubMed/NCBI

51 

Méndez-Bolaina E, Sánchez-González J, Ramírez-Sánchez I, Ocharán-Hernández E, Núñez-Sánchez M, Meaney-Mendiolea E, Meaney A, Asbun-Bojalil J, Miliar-García A, Olivares-Corichi I and Ceballos-Reyes G: Effect of caveolin-1 scaffolding peptide and 17beta-estradiol on intracellular Ca2+ kinetics evoked by angiotensin II in human vascular smooth muscle cells. Am J Physiol Cell Physiol. 293:C1953–C1961. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Ishikawa T, Yuhanna IS, Umetani J, Lee WR, Korach KS, Shaul PW and Umetani M: LXRβ/estrogen receptor-α signaling in lipid rafts preserves endothelial integrity. J Clin Invest. 123:3488–3497. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Abi-Char J, Maguy A, Coulombe A, Balse E, Ratajczak P, Samuel JL, Nattel S and Hatem SN: Membrane cholesterol modulates Kv1.5 potassium channel distribution and function in rat cardiomyocytes. J Physiol. 582:1205–1217. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Qu C, Sun J, Liu Y, Wang X, Wang L, Han C, Chen Q, Guan T, Li H, Zhang Y, Zhang Y, et al: Caveolin‑1 facilitated KCNA5 expression, promoting breast cancer viability. Oncol Lett 16: 4829-4838, 2018.
APA
Qu, C., Sun, J., Liu, Y., Wang, X., Wang, L., Han, C. ... Liu, J. (2018). Caveolin‑1 facilitated KCNA5 expression, promoting breast cancer viability. Oncology Letters, 16, 4829-4838. https://doi.org/10.3892/ol.2018.9261
MLA
Qu, C., Sun, J., Liu, Y., Wang, X., Wang, L., Han, C., Chen, Q., Guan, T., Li, H., Zhang, Y., Wang, Y., Liu, J., Zou, W., Liu, J."Caveolin‑1 facilitated KCNA5 expression, promoting breast cancer viability". Oncology Letters 16.4 (2018): 4829-4838.
Chicago
Qu, C., Sun, J., Liu, Y., Wang, X., Wang, L., Han, C., Chen, Q., Guan, T., Li, H., Zhang, Y., Wang, Y., Liu, J., Zou, W., Liu, J."Caveolin‑1 facilitated KCNA5 expression, promoting breast cancer viability". Oncology Letters 16, no. 4 (2018): 4829-4838. https://doi.org/10.3892/ol.2018.9261
Copy and paste a formatted citation
x
Spandidos Publications style
Qu C, Sun J, Liu Y, Wang X, Wang L, Han C, Chen Q, Guan T, Li H, Zhang Y, Zhang Y, et al: Caveolin‑1 facilitated KCNA5 expression, promoting breast cancer viability. Oncol Lett 16: 4829-4838, 2018.
APA
Qu, C., Sun, J., Liu, Y., Wang, X., Wang, L., Han, C. ... Liu, J. (2018). Caveolin‑1 facilitated KCNA5 expression, promoting breast cancer viability. Oncology Letters, 16, 4829-4838. https://doi.org/10.3892/ol.2018.9261
MLA
Qu, C., Sun, J., Liu, Y., Wang, X., Wang, L., Han, C., Chen, Q., Guan, T., Li, H., Zhang, Y., Wang, Y., Liu, J., Zou, W., Liu, J."Caveolin‑1 facilitated KCNA5 expression, promoting breast cancer viability". Oncology Letters 16.4 (2018): 4829-4838.
Chicago
Qu, C., Sun, J., Liu, Y., Wang, X., Wang, L., Han, C., Chen, Q., Guan, T., Li, H., Zhang, Y., Wang, Y., Liu, J., Zou, W., Liu, J."Caveolin‑1 facilitated KCNA5 expression, promoting breast cancer viability". Oncology Letters 16, no. 4 (2018): 4829-4838. https://doi.org/10.3892/ol.2018.9261
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team