Open Access

Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma

  • Authors:
    • Peng Sheng Yi
    • Bin Wu
    • Da Wei Deng
    • Guang Nian Zhang
    • Jian Shui Li
  • View Affiliations

  • Published online on: August 10, 2018     https://doi.org/10.3892/ol.2018.9295
  • Pages: 5122-5130
  • Copyright: © Yi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The objective of the present study was to investigate the association between zinc finger protein (ZNF) 689 expression and the clinicopathological features and prognosis of hepatocellular carcinoma (HCC). A total of 102 paired HCC and paired non‑cancerous tissues, and 16 normal liver tissues were collected. ZNF689 expression was examined in HCC tissues, paired‑noncancerous tissues, and normal liver tissues using RT‑qPCR and immunohistochemistry analysis, and the association between ZNF689 expression and HCC prognosis was analyzed using the Kaplan‑Meier method. ZNF689 expression was not significantly different between HCC tissues and paired‑noncancerous tissues (P=0.61). ZNF689 expression in HCC and paired‑noncancerous tissues was significantly increased compared with that in normal liver tissues (P<0.01). Positive expression of ZNF689 protein in HCC was significantly associated with a tumor size of ≥10 cm, tumor capsule infiltration, and microvascular invasion (P<0.05). Positive expression of ZNF689 was a prognostic factor for overall survival time [hazard ratio (HR):1.961; P=0.048] and progression‑free survival time (HR:1.902; P=0.041). ZNF689 maybe a novel predictor for prognosis of patients with HCC.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yi PS, Wu B, Deng DW, Zhang GN and Li JS: Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma. Oncol Lett 16: 5122-5130, 2018
APA
Yi, P.S., Wu, B., Deng, D.W., Zhang, G.N., & Li, J.S. (2018). Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma. Oncology Letters, 16, 5122-5130. https://doi.org/10.3892/ol.2018.9295
MLA
Yi, P. S., Wu, B., Deng, D. W., Zhang, G. N., Li, J. S."Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma". Oncology Letters 16.4 (2018): 5122-5130.
Chicago
Yi, P. S., Wu, B., Deng, D. W., Zhang, G. N., Li, J. S."Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma". Oncology Letters 16, no. 4 (2018): 5122-5130. https://doi.org/10.3892/ol.2018.9295