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Article Open Access

Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma

  • Authors:
    • Peng Sheng Yi
    • Bin Wu
    • Da Wei Deng
    • Guang Nian Zhang
    • Jian Shui Li
  • View Affiliations / Copyright

    Affiliations: Department of Hepato‑Biliary‑Pancrease, Institute of General Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 639000, P.R. China
    Copyright: © Yi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5122-5130
    |
    Published online on: August 10, 2018
       https://doi.org/10.3892/ol.2018.9295
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Abstract

The objective of the present study was to investigate the association between zinc finger protein (ZNF) 689 expression and the clinicopathological features and prognosis of hepatocellular carcinoma (HCC). A total of 102 paired HCC and paired non‑cancerous tissues, and 16 normal liver tissues were collected. ZNF689 expression was examined in HCC tissues, paired‑noncancerous tissues, and normal liver tissues using RT‑qPCR and immunohistochemistry analysis, and the association between ZNF689 expression and HCC prognosis was analyzed using the Kaplan‑Meier method. ZNF689 expression was not significantly different between HCC tissues and paired‑noncancerous tissues (P=0.61). ZNF689 expression in HCC and paired‑noncancerous tissues was significantly increased compared with that in normal liver tissues (P<0.01). Positive expression of ZNF689 protein in HCC was significantly associated with a tumor size of ≥10 cm, tumor capsule infiltration, and microvascular invasion (P<0.05). Positive expression of ZNF689 was a prognostic factor for overall survival time [hazard ratio (HR):1.961; P=0.048] and progression‑free survival time (HR:1.902; P=0.041). ZNF689 maybe a novel predictor for prognosis of patients with HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Yi PS, Wu B, Deng DW, Zhang GN and Li JS: Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma. Oncol Lett 16: 5122-5130, 2018.
APA
Yi, P.S., Wu, B., Deng, D.W., Zhang, G.N., & Li, J.S. (2018). Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma. Oncology Letters, 16, 5122-5130. https://doi.org/10.3892/ol.2018.9295
MLA
Yi, P. S., Wu, B., Deng, D. W., Zhang, G. N., Li, J. S."Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma". Oncology Letters 16.4 (2018): 5122-5130.
Chicago
Yi, P. S., Wu, B., Deng, D. W., Zhang, G. N., Li, J. S."Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma". Oncology Letters 16, no. 4 (2018): 5122-5130. https://doi.org/10.3892/ol.2018.9295
Copy and paste a formatted citation
x
Spandidos Publications style
Yi PS, Wu B, Deng DW, Zhang GN and Li JS: Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma. Oncol Lett 16: 5122-5130, 2018.
APA
Yi, P.S., Wu, B., Deng, D.W., Zhang, G.N., & Li, J.S. (2018). Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma. Oncology Letters, 16, 5122-5130. https://doi.org/10.3892/ol.2018.9295
MLA
Yi, P. S., Wu, B., Deng, D. W., Zhang, G. N., Li, J. S."Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma". Oncology Letters 16.4 (2018): 5122-5130.
Chicago
Yi, P. S., Wu, B., Deng, D. W., Zhang, G. N., Li, J. S."Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma". Oncology Letters 16, no. 4 (2018): 5122-5130. https://doi.org/10.3892/ol.2018.9295
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