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Clinicopathological characteristics and prognostic factors of gastrointestinal stromal tumors in Chinese patients

  • Authors:
    • Ming‑Lei Yang
    • Jun‑Cheng Wang
    • Wen‑Bin Zou
    • Ding‑Kang Yao
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China, Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4905-4914
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    Published online on: August 17, 2018
       https://doi.org/10.3892/ol.2018.9320
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Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms in the gastrointestinal tract, exhibiting wide variability in their biological behavior. The aim of the present study was to investigate the clinicopathological characteristics and prognostic factors of GISTs in Chinese patients. All GIST cases (n=182) retrieved from the pathology database and the archived files in Shanghai Changzheng Hospital between January 2011 and December 2014 were reviewed. The clinical symptoms, preoperative investigations, treatments, pathological characteristics and follow‑up data of these patients were reviewed, and univariate and multivariate survival analyses were performed. A total of 73.1% of the GISTs were located in the stomach, and the most common three symptoms included abdominal pain (30.2%), dyspepsia (23.1%) and gastrointestinal bleeding (21.4%). Univariate analysis revealed that larger tumor size (P<0.001), higher mitotic rate (P<0.001), aggressive behavior (P<0.001), negative smooth muscle actin expression (P=0.009) and palliative resection (P<0.001) contributed toward poor overall survival (OS). In addition, non‑gastric disease location (P<0.001), larger tumor size (P<0.001), higher mitotic rate (P=0.004), aggressive behavior (P<0.001) and palliative resection (P<0.001) were associated with poor relapse‑free survival (RFS). Multivariate analysis indicated that mitotic rate [hazard ratio (HR=3.761, P=0.015)] and aggressive behavior (HR=3.916, P=0.010) were independent risk factors for OS, while non‑gastric location (HR=4.740, P=0.002) and aggressive behavior (HR=4.009, P=0.004) were independent risk factors for RFS. The present study provided information on the clinicopathological characteristics and epidemiology of GISTs in the Chinese population. Non‑gastric disease location, higher mitotic rate and tumor metastasis or local invasion prior to treatment were identified as predictors of a poor prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Yang ML, Wang JC, Zou WB and Yao DK: Clinicopathological characteristics and prognostic factors of gastrointestinal stromal tumors in Chinese patients. Oncol Lett 16: 4905-4914, 2018.
APA
Yang, M., Wang, J., Zou, W., & Yao, D. (2018). Clinicopathological characteristics and prognostic factors of gastrointestinal stromal tumors in Chinese patients. Oncology Letters, 16, 4905-4914. https://doi.org/10.3892/ol.2018.9320
MLA
Yang, M., Wang, J., Zou, W., Yao, D."Clinicopathological characteristics and prognostic factors of gastrointestinal stromal tumors in Chinese patients". Oncology Letters 16.4 (2018): 4905-4914.
Chicago
Yang, M., Wang, J., Zou, W., Yao, D."Clinicopathological characteristics and prognostic factors of gastrointestinal stromal tumors in Chinese patients". Oncology Letters 16, no. 4 (2018): 4905-4914. https://doi.org/10.3892/ol.2018.9320
Copy and paste a formatted citation
x
Spandidos Publications style
Yang ML, Wang JC, Zou WB and Yao DK: Clinicopathological characteristics and prognostic factors of gastrointestinal stromal tumors in Chinese patients. Oncol Lett 16: 4905-4914, 2018.
APA
Yang, M., Wang, J., Zou, W., & Yao, D. (2018). Clinicopathological characteristics and prognostic factors of gastrointestinal stromal tumors in Chinese patients. Oncology Letters, 16, 4905-4914. https://doi.org/10.3892/ol.2018.9320
MLA
Yang, M., Wang, J., Zou, W., Yao, D."Clinicopathological characteristics and prognostic factors of gastrointestinal stromal tumors in Chinese patients". Oncology Letters 16.4 (2018): 4905-4914.
Chicago
Yang, M., Wang, J., Zou, W., Yao, D."Clinicopathological characteristics and prognostic factors of gastrointestinal stromal tumors in Chinese patients". Oncology Letters 16, no. 4 (2018): 4905-4914. https://doi.org/10.3892/ol.2018.9320
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