Open Access

miR‑124 regulates STAT3‑mediated cell proliferation, migration and apoptosis in bladder cancer

  • Authors:
    • Shengxing Wang
    • Gang Wu
    • Yinan Han
    • Peng Song
    • Jinhuo Chen
    • Yaoxi Wu
    • Jie Yang
    • Peiyu Liang
  • View Affiliations

  • Published online on: August 21, 2018     https://doi.org/10.3892/ol.2018.9341
  • Pages: 5875-5881
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The etiology and pathogenesis of bladder cancer (BCa) is complex. MicroRNA (miRNA) has been implicated in BCa. Targeting of signal transducer and activator of transcription 3 (STAT3) by miR‑124 to regulate tumorigenesis has been demonstrated in other types of cancer. In the present study, miR‑124 levels were downregulated in the BCa T24 cell line and STAT3 was increased in BCa cell lines. Transfection of miR‑124 mimics into T24 cells significantly inhibited STAT3 expression. A luciferase assay confirmed that miR‑124 directly targeted the STAT3 3'untranslated region to inhibit STAT expression. Knockdown of STAT3 expression led to increased apoptosis of T24 cells and reduced tumor growth in vitro. The results demonstrated the molecular mechanisms and biological functions of the miR‑124/STAT3 signal pathway at the cellular level and indicate the potential of miR‑124 as a therapeutic target for BCa.
View Figures
View References

Related Articles

Journal Cover

November-2018
Volume 16 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang S, Wu G, Han Y, Song P, Chen J, Wu Y, Yang J and Liang P: miR‑124 regulates STAT3‑mediated cell proliferation, migration and apoptosis in bladder cancer. Oncol Lett 16: 5875-5881, 2018
APA
Wang, S., Wu, G., Han, Y., Song, P., Chen, J., Wu, Y. ... Liang, P. (2018). miR‑124 regulates STAT3‑mediated cell proliferation, migration and apoptosis in bladder cancer. Oncology Letters, 16, 5875-5881. https://doi.org/10.3892/ol.2018.9341
MLA
Wang, S., Wu, G., Han, Y., Song, P., Chen, J., Wu, Y., Yang, J., Liang, P."miR‑124 regulates STAT3‑mediated cell proliferation, migration and apoptosis in bladder cancer". Oncology Letters 16.5 (2018): 5875-5881.
Chicago
Wang, S., Wu, G., Han, Y., Song, P., Chen, J., Wu, Y., Yang, J., Liang, P."miR‑124 regulates STAT3‑mediated cell proliferation, migration and apoptosis in bladder cancer". Oncology Letters 16, no. 5 (2018): 5875-5881. https://doi.org/10.3892/ol.2018.9341