Prognostic impact of soluble intercellular adhesion molecule‑1 in hepatocellular carcinoma

Shimura,Tatsuo; Shibata,Masahiko; Gonda,Kenji; Kofunato,Yasuhide; Ishigame,Teruhide; Okada,Ryo; Sato,Naoya; Kimura,Takashi; Kenjo,Akira; Marubashi,Shigeru

doi:10.3892/ol.2018.9367

Prognostic impact of soluble intercellular adhesion molecule‑1 in hepatocellular carcinoma

Authors:
- Tatsuo Shimura
- Masahiko Shibata
- Kenji Gonda
- Yasuhide Kofunato
- Teruhide Ishigame
- Ryo Okada
- Naoya Sato
- Takashi Kimura
- Akira Kenjo
- Shigeru Marubashi
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Affiliations: Department of Hepato‑Biliary‑Pancreatic and Transplant Surgery, Fukushima Medical University, Fukushima 960‑1259, Japan, Department of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960‑1259, Japan
Published online on: August 24, 2018 https://doi.org/10.3892/ol.2018.9367
Pages: 6013-6018

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Abstract

The identification of novel biomarkers for hepatocellular carcinoma (HCC) is of great importance in improving the outcome of patients with HCC. The present study aimed to determine the prognostic significance of the soluble intercellular adhesion molecule (sICAM)‑1 in patients with HCC. The present study prospectively collected clinicopathological data from 36 patients with HCC who had undergone successful hepatectomy. An analysis using a receiver operating characteristic (ROC) curve was performed to determine the cut‑off value for predicting prognosis. Overall survival (OS), recurrence‑free survival (RFS) and potential prognostic factors were analyzed. The ROC curve analysis revealed a sICAM‑1 cut‑off value of 440 ng/ml. HCC patients with sICAM‑1 ≥440 ng/ml exhibited a poorer OS and RFS than those with sICAM‑1 <440 ng/ml (P=0.002). sICAM‑1 ≥440 ng/ml (hazard ratio=3.623; 95% confidence interval: 1.145‑11.458; P=0.028) and Child B (hazard ratio=1.514; 95% confidence interval: 1.066‑2.150; P=0.021) were independent prognostic factors for OS, and sICAM‑1 ≥440 ng/ml was an independent prognostic factor for RFS (hazard ratio=3.625; 95% confidence interval: 1.233‑10.659; P=0.019). Serum sICAM‑1 may be a promising predictor for the overall and recurrence‑free survival of patients with HCC.

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