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Article Open Access

High concordance of TMPRSS‑ERG fusion between primary prostate cancer and its lymph node metastases

  • Authors:
    • Franziska Brandi
    • Katharina Grupp
    • Claudia Hube‑Magg
    • Martina Kluth
    • Dagmar Lang
    • Sarah Minner
    • Christina Möller‑Koop
    • Markus Graefen
    • Hans Heinzer
    • Maria Christina Tsourlakis
    • Corinna Wittmer
    • Frank Jacobsen
    • Hartwig Huland
    • Stefan Steurer
    • Patrick Lebok
    • Andrea Hinsch
    • Waldemar Wilczak
    • Thorsten Schlomm
    • Ronald Simon
  • View Affiliations / Copyright

    Affiliations: Institute of Pathology, University Medical Center Hamburg‑Eppendorf, Hamburg D‑20246, Germany, General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg‑Eppendorf, Hamburg D‑20246, Germany, Martini‑Clinic, Prostate Cancer Center, University Medical Center Hamburg‑Eppendorf, Hamburg D‑20246, Germany
    Copyright: © Brandi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6238-6244
    |
    Published online on: September 7, 2018
       https://doi.org/10.3892/ol.2018.9417
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Abstract

Approximately 50% of prostate cancer types harbor the transmembrane protease, serine 2: Erythroblast transformation‑specific‑related gene (ERG) fusion, resulting in oncogenic expression of the ERG transcription factor. ERG represents an attractive target for potential future anticancer therapy in advanced and metastatic prostate cancer. To better understand whether the analysis of the primary cancer is sufficient to estimate the ERG expression status of the lymph node metastases, the present study examined patterns of immunohistochemical ERG expression in a tissue microarray created from multiple primary and metastatic sites of 77 prostate cancer tissues. Among the identified tumor types, 80% were either entirely ERG‑positive (38%) or ERG‑negative (42%) across all (at least 9) analyzed different tumor sites. The results were heterogeneous in 20% of the tumor types and typically resulted from small ERG‑negative areas within otherwise ERG‑positive tumor types. Comparison of the ERG expression status in 51 primary cancer types with at least three interpretable lymph node metastases revealed an entirely identical ERG status in all tumor sites in 75% of the cases, including 16 ERG‑positive and 22 ERG‑negative cancer types. The remaining 13 cancer types exhibited ERG heterogeneity within the primary tumor, while all metastases had an identical (12 positive and 1 negative) ERG status. The results of the present study revealed a high degree of concordance of the ERG expression status between primary prostate cancer types and their lymph node metastases. Therefore, potential anti‑ERG therapy may also be effective against lymph node metastases in the majority of cases of ERG‑positive metastatic prostate cancer.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Cai T, Nesi G, Tinacci G, Giubilei G, Gavazzi A, Mondaini N, Zini E and Bartoletti R: Clinical importance of lymph node density in predicting outcome of prostate cancer patients. J Surg Res. 167:267–272. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Bader P, Burkhard FC, Markwalder R and Studer UE: Disease progression and survival of patients with positive lymph nodes after radical prostatectomy. Is there a chance of cure? J Urol. 169:849–854. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Weckermann D, Dorn R, Trefz M, Wagner T, Wawroschek F and Harzmann R: Sentinel lymph node dissection for prostate cancer: Experience with more than 1,000 patients. J Urol. 177:916–920. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Gervasi LA, Mata J, Easley JD, Wilbanks JH, Seale-Hawkins C, Carlton CE Jr and Scardino PT: Prognostic significance of lymph nodal metastases in prostate cancer. J Urol. 142:332–336. 1989. View Article : Google Scholar : PubMed/NCBI

6 

Cheng L, Zincke H, Blute ML, Bergstralh EJ, Scherer B and Bostwick DG: Risk of prostate carcinoma death in patients with lymph node metastasis. Cancer. 91:66–73. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Zwergel U, Lehmann J, Wullich B, Schreier U, Remberger K, Zwergel T and Stoeckle M: Lymph node positive prostate cancer: Long-term survival data after radical prostatectomy. J Urol. 171:1128–1131. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Fleischmann A, Rocha C, Schobinger S, Seiler R, Wiese B and Thalmann GN: Androgen receptors are differentially expressed in Gleason patterns of prostate cancer and down-regulated in matched lymph node metastases. Prostate. 71:453–460. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Ko K, Jeong IG, Choi WS, Lim JH, Suh JH, Ku JH, Park Y, Moon KC, Kim HH, Kim CS and Kwak C: Effect of Gleason scores of lymph node metastases on prognosis of patients with prostate cancer. Int J Clin Exp Pathol. 7:6141–6148. 2014.PubMed/NCBI

10 

Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, et al: Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 310:644–648. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Urbinati G, Ali HM, Rousseau Q, Chapuis H, Desmaële D, Couvreur P and Massaad-Massade L: Antineoplastic effects of siRNA against TMPRSS2-ERG junction oncogene in prostate cancer. PLoS One. 10:e01252772015. View Article : Google Scholar : PubMed/NCBI

12 

Urbinati G, de Waziers I, Slamiç M, Foussignière T, Ali HM, Desmaële D, Couvreur P and Massaad-Massade L: Knocking down TMPRSS2-ERG fusion oncogene by siRNA could be an alternative treatment to flutamide. Mol Ther Nucleic Acids. 5:e3012016. View Article : Google Scholar : PubMed/NCBI

13 

Shao L, Tekedereli I, Wang J, Yuca E, Tsang S, Sood A, Lopez-Berestein G, Ozpolat B and Ittmann M: Highly specific targeting of the TMPRSS2/ERG fusion gene using liposomal nanovectors. Clin Cancer Res. 18:6648–6657. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Wang X, Qiao Y, Asangani IA, Ateeq B, Poliakov A, Cieślik M, Pitchiaya S, Chakravarthi BVSK, Cao X, Jing X, et al: Development of peptidomimetic inhibitors of the ERG gene fusion product in prostate cancer. Cancer Cell. 31(532–548): e72017.

15 

Furusato B, Tan SH, Young D, Dobi A, Sun C, Mohamed AA, Thangapazham R, Chen Y, McMaster G, Sreenath T, et al: ERG oncoprotein expression in prostate cancer: Clonal progression of ERG-positive tumor cells and potential for ERG-based stratification. Prostate Cancer Prostatic Dis. 13:228–237. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Mehra R, Tomlins SA, Shen R, Nadeem O, Wang L, Wei JT, Pienta KJ, Ghosh D, Rubin MA, Chinnaiyan AM and Shah RB: Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer. Mod Pathol. 20:538–544. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Minner S, Gärtner M, Freudenthaler F, Bauer M, Kluth M, Salomon G, Heinzer H, Graefen M, Bokemeyer C, Simon R, et al: Marked heterogeneity of ERG expression in large primary prostate cancers. Mod Pathol. 26:106–116. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Tsourlakis MC, Stender A, Quaas A, Kluth M, Wittmer C, Haese A, Graefen M, Steurer S, Simon R, Korbel J, et al: Heterogeneity of ERG expression in prostate cancer: A large section mapping study of entire prostatectomy specimens from 125 patients. BMC Cancer. 16:6412016. View Article : Google Scholar : PubMed/NCBI

19 

Minner S, Enodien M, Sirma H, Luebke AM, Krohn A, Mayer PS, Simon R, Tennstedt P, Müller J, Scholz L, et al: ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy. Clin Cancer Res. 17:5878–5888. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Fleischmann A, Saramäki OR, Zlobec I, Rotzer D, Genitsch V, Seiler R, Visakorpi T and Thalmann GN: Prevalence and prognostic significance of TMPRSS2-ERG gene fusion in lymph node positive prostate cancers. Prostate. 74:1647–1654. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Wise AM, Stamey TA, McNeal JE and Clayton JL: Morphologic and clinical significance of multifocal prostate cancers in radical prostatectomy specimens. Urology. 60:264–269. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Clement T, Swars H, Boerner N, Klose KJ, John H, Warnecke M and Weilemann LS: Venous occlusive disease of the liver-a rare pregnancy complication. Internist (Berl). 31:297–300. 1990.(In German). PubMed/NCBI

23 

Barry M, Perner S, Demichelis F and Rubin MA: TMPRSS2-ERG fusion heterogeneity in multifocal prostate cancer: Clinical and biologic implications. Urology. 70:630–633. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Svensson MA, LaFargue CJ, MacDonald TY, Pflueger D, Kitabayashi N, Santa-Cruz AM, Garsha KE, Sathyanarayana UG, Riley JP, Yun CS, et al: Testing mutual exclusivity of ETS rearranged prostate cancer. Lab Invest. 91:404–412. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Zhang S, Pavlovitz B, Tull J, Wang Y, Deng FM and Fuller C: Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization. Diagn Mol Pathol. 19:151–156. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Font-Tello A, Juanpere N, de Muga S, Lorenzo M, Lorente JA, Fumado L, Serrano L, Serrano S, Lloreta J and Hernández S: Association of ERG and TMPRSS2-ERG with grade, stage, and prognosis of prostate cancer is dependent on their expression levels. Prostate. 75:1216–1226. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Hagen RM, Adamo P, Karamat S, Oxley J, Aning JJ, Gillatt D, Persad R, Ladomery MR and Rhodes A: Quantitative analysis of ERG expression and its splice isoforms in formalin-fixed, paraffin-embedded prostate cancer samples: Association with seminal vesicle invasion and biochemical recurrence. Am J Clin Pathol. 142:533–540. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Hägglöf C, Hammarsten P, Strömvall K, Egevad L, Josefsson A, Stattin P, Granfors T and Bergh A: TMPRSS2-ERG expression predicts prostate cancer survival and associates with stromal biomarkers. PLoS One. 9:e868242014. View Article : Google Scholar : PubMed/NCBI

29 

Klein EA, Falzarano SM, Maddala T, Cherbavaz D, Novotny WF, Millward C and Magi-Galluzzi C: Use of TMPRSS2-ERG gene rearrangement and quantitative ERG expression to predict clinical recurrence after radical prostatectomy. J Clin Oncol. 29 Suppl:S362011. View Article : Google Scholar

30 

Terry S, Nicolaiew N, Basset V, Semprez F, Soyeux P, Maillé P, Vacherot F, Ploussard G, Londoño-Vallejo A, de la Taille A and Allory Y: Clinical value of ERG, TFF3, and SPINK1 for molecular subtyping of prostate cancer. Cancer. 121:1422–1430. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Guo CC, Wang Y, Xiao L, Troncoso P and Czerniak BA: The relationship of TMPRSS2-ERG gene fusion between primary and metastatic prostate cancers. Hum Pathol. 43:644–649. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Perner S, Svensson MA, Hossain RR, Day JR, Groskopf J, Slaughter RC, Jarleborn AR, Hofer MD, Kuefer R, Demichelis F, et al: ERG rearrangement metastasis patterns in locally advanced prostate cancer. Urology. 75:762–767. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Tomlins SA, Laxman B, Dhanasekaran SM, Helgeson BE, Cao X, Morris DS, Menon A, Jing X, Cao Q, Han B, et al: Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature. 448:595–599. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Carver BS, Tran J, Chen Z, Carracedo-Perez A, Alimonti A, Nardella C, Gopalan A, Scardino PT, Cordon-Cardo C, Gerald W and Pandolfi PP: ETS rearrangements and prostate cancer initiation. Nature. 457(E1): discussion E2-E3. 2009.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Brandi F, Grupp K, Hube‑Magg C, Kluth M, Lang D, Minner S, Möller‑Koop C, Graefen M, Heinzer H, Tsourlakis M, Tsourlakis M, et al: High concordance of TMPRSS‑ERG fusion between primary prostate cancer and its lymph node metastases. Oncol Lett 16: 6238-6244, 2018.
APA
Brandi, F., Grupp, K., Hube‑Magg, C., Kluth, M., Lang, D., Minner, S. ... Simon, R. (2018). High concordance of TMPRSS‑ERG fusion between primary prostate cancer and its lymph node metastases. Oncology Letters, 16, 6238-6244. https://doi.org/10.3892/ol.2018.9417
MLA
Brandi, F., Grupp, K., Hube‑Magg, C., Kluth, M., Lang, D., Minner, S., Möller‑Koop, C., Graefen, M., Heinzer, H., Tsourlakis, M., Wittmer, C., Jacobsen, F., Huland, H., Steurer, S., Lebok, P., Hinsch, A., Wilczak, W., Schlomm, T., Simon, R."High concordance of TMPRSS‑ERG fusion between primary prostate cancer and its lymph node metastases". Oncology Letters 16.5 (2018): 6238-6244.
Chicago
Brandi, F., Grupp, K., Hube‑Magg, C., Kluth, M., Lang, D., Minner, S., Möller‑Koop, C., Graefen, M., Heinzer, H., Tsourlakis, M., Wittmer, C., Jacobsen, F., Huland, H., Steurer, S., Lebok, P., Hinsch, A., Wilczak, W., Schlomm, T., Simon, R."High concordance of TMPRSS‑ERG fusion between primary prostate cancer and its lymph node metastases". Oncology Letters 16, no. 5 (2018): 6238-6244. https://doi.org/10.3892/ol.2018.9417
Copy and paste a formatted citation
x
Spandidos Publications style
Brandi F, Grupp K, Hube‑Magg C, Kluth M, Lang D, Minner S, Möller‑Koop C, Graefen M, Heinzer H, Tsourlakis M, Tsourlakis M, et al: High concordance of TMPRSS‑ERG fusion between primary prostate cancer and its lymph node metastases. Oncol Lett 16: 6238-6244, 2018.
APA
Brandi, F., Grupp, K., Hube‑Magg, C., Kluth, M., Lang, D., Minner, S. ... Simon, R. (2018). High concordance of TMPRSS‑ERG fusion between primary prostate cancer and its lymph node metastases. Oncology Letters, 16, 6238-6244. https://doi.org/10.3892/ol.2018.9417
MLA
Brandi, F., Grupp, K., Hube‑Magg, C., Kluth, M., Lang, D., Minner, S., Möller‑Koop, C., Graefen, M., Heinzer, H., Tsourlakis, M., Wittmer, C., Jacobsen, F., Huland, H., Steurer, S., Lebok, P., Hinsch, A., Wilczak, W., Schlomm, T., Simon, R."High concordance of TMPRSS‑ERG fusion between primary prostate cancer and its lymph node metastases". Oncology Letters 16.5 (2018): 6238-6244.
Chicago
Brandi, F., Grupp, K., Hube‑Magg, C., Kluth, M., Lang, D., Minner, S., Möller‑Koop, C., Graefen, M., Heinzer, H., Tsourlakis, M., Wittmer, C., Jacobsen, F., Huland, H., Steurer, S., Lebok, P., Hinsch, A., Wilczak, W., Schlomm, T., Simon, R."High concordance of TMPRSS‑ERG fusion between primary prostate cancer and its lymph node metastases". Oncology Letters 16, no. 5 (2018): 6238-6244. https://doi.org/10.3892/ol.2018.9417
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