Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process

  • Authors:
    • Chin‑Fu Chen
    • Chi‑Cheng Lu
    • Jo‑Hua Chiang
    • Hong‑Yi Chiu
    • Jai‑Sing Yang
    • Chao‑Ying Lee
    • Tzong‑Der Way
    • Hao‑Jen Huang
  • View Affiliations / Copyright

    Affiliations: Department of Life Sciences, National Cheng Kung University, Tainan 701, Taiwan, R.O.C., Department of Pharmacy, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan, R.O.C., Department of Nursing, Chung Jen Catholic Junior College, Chiayi County 622, Taiwan, R.O.C., Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan, R.O.C., Department of Pharmacy, China Medical University, Taichung 404, Taiwan, R.O.C. , Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan, R.O.C.
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6323-6330
    |
    Published online on: September 7, 2018
       https://doi.org/10.3892/ol.2018.9418
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cetuximab, an epidermal growth factor receptor (EGFR)-targeting monoclonal antibody (mAb), is a novel targeted therapy for the treatment of patients with oral cancer. Cetuximab can be used in combination with chemotherapeutic agents to prolong the overall survival rates of patients with oral cancer. Curcumin is a traditional Chinese medicine, and it has been demonstrated to have growth‑inhibiting effects on oral cancer cells. However, information regarding the combination of cetuximab and curcumin in drug‑resistant oral cancer cells is lacking, and its underlying mechanism remains unclear. The purpose of the present study was to explore the oral anticancer effects of cetuximab combined with curcumin on cisplatin‑resistant oral cancer CAR cell apoptosis in vitro. The results demonstrated that combination treatment synergistically potentiated the effect of cetuximab and curcumin on the suppression of cell viability and induction of apoptosis in CAR cells. Cetuximab and curcumin combination induced apoptosis and dramatically increased caspase‑3 and caspase‑9 activities compared with singular treatment. Combination treatment also markedly suppressed the protein expression levels of EGFR and mitogen‑activated protein kinases (MAPKs) signaling (phosphorylation of ERK, JNK and p38). The results demonstrated that co‑treatment with cetuximab and curcumin exerts synergistic oral anticancer effects on CAR cells through the suppression of the EGFR signaling by regulation of the MAPK pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Horn D, Hess J, Freier K, Hoffmann J and Freudlsperger C: Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma. Expert Opin Ther Targets. 19:795–805. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Prince A, Aguirre-Ghizo J, Genden E, Posner M and Sikora A: Head and neck squamous cell carcinoma: New translational therapies. Mt Sinai J Med. 77:684–699. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Mendelsohn J and Baselga J: Epidermal growth factor receptor targeting in cancer. Semin Oncol. 33:369–385. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Todd R and Wong DT: Epidermal growth factor receptor (EGFR) biology and human oral cancer. Histol Histopathol. 14:491–500. 1999.PubMed/NCBI

5 

Pickhard A, Siegl M, Baumann A, Huhn M, Wirth M, Reiter R, Rudelius M, Piontek G and Brockhoff G: The response of head and neck squamous cell carcinoma to cetuximab treatment depends on Aurora kinase A polymorphism. Oncotarget. 5:5428–5438. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Lin MC, Huang MJ, Liu CH, Yang TL and Huang MC: GALNT2 enhances migration and invasion of oral squamous cell carcinoma by regulating EGFR glycosylation and activity. Oral Oncol. 50:478–484. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Cassell A and Grandis JR: Investigational EGFR-targeted therapy in head and neck squamous cell carcinoma. Expert Opin Investig Drugs. 19:709–722. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Hoch MA, Cousins K, Nartey R, Riley K and Hartranft M: Two cases of combination therapy with cetuximab, paclitaxel, and cisplatin for advanced head and neck cancer. J Oncol Pharm Pract 1078155217722406. 2017.

9 

Liebig H, Günther G, Kolb M, Mozet C, Boehm A, Dietz A and Wichmann G: Reduced proliferation and colony formation of head and neck squamous cell carcinoma (HNSCC) after dual targeting of EGFR and hedgehog pathways. Cancer Chemother Pharmacol. 79:411–420. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Moon C, Chae YK and Lee J: Targeting epidermal growth factor receptor in head and neck cancer: Lessons learned from cetuximab. Exp Biol Med (Maywood). 235:907–920. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Astsaturov I, Cohen RB and Harari P: EGFR-targeting monoclonal antibodies in head and neck cancer. Curr Cancer Drug Targets. 6:691–710. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Dai W, Li Y, Zhou Q, Xu Z, Sun C, Tan X and Lu L: Cetuximab inhibits oral squamous cell carcinoma invasion and metastasis via degradation of epidermal growth factor receptor. J Oral Pathol Med. 43:250–257. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Psyrri A, Seiwert TY and Jimeno A: Molecular pathways in head and neck cancer: EGFR, PI3K, and more. Am Soc Clin Oncol Educ Book. 246–255. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Astsaturov I, Cohen RB and Harari P: EGFR-targeting monoclonal antibodies in head and neck cancer. Curr Cancer Drug Targets. 7:650–665. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Burgy M, Barthélémy P, Lefevre F, Dupret-Bories A, Truntzer P, Korenbaum C, Flesch H, Bronner G and Borel C: Cetuximab-carboplatin-5-fluorouracil regimen in elderly patients with recurrent or metastatic head and neck squamous-cell carcinoma: A French retrospective survey. Oncology. 93:11–17. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Guigay J, Even C, Mayache-Badis L, Debbah M, Saada-Bouzid E, Tao Y, Deschamps F, Janot F, Lezghed N and Michel C: Long-term response in patient with recurrent oropharyngeal carcinoma treated with cetuximab, docetaxel and cisplatin (TPEx) as first-line treatment followed by cetuximab maintenance. Oral Oncol. 68:114–118. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Unlu A, Nayir E, Kalenderoglu Dogukan M, Kirca O and Ozdogan M: Curcumin (Turmeric) and cancer. J BUON. 21:1050–1060. 2016.PubMed/NCBI

18 

He Y, Yue Y, Zheng X, Zhang K, Chen S and Du Z: Curcumin, inflammation, and chronic diseases: How are they linked? Molecules. 20:9183–9213. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Wang J and Jiang YF: Natural compounds as anticancer agents: Experimental evidence. World J Exp Med. 2:45–57. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Chen ZF and Liang H: Progresses in TCM metal-based antitumour agents. Anticancer Agents Med Chem. 10:412–423. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Devi Pandima K, Rajavel T, Daglia M, Nabavi SF, Bishayee A and Nabavi SM: Targeting miRNAs by polyphenols: Novel therapeutic strategy for cancer. Semin Cancer Biol. 46:146–157. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Owen HC, Appiah S, Hasan N, Ghali L, Elayat G and Bell C: Phytochemical modulation of apoptosis and autophagy: Strategies to overcome chemoresistance in leukemic stem cells in the bone marrow microenvironment. Int Rev Neurobiol. 135:249–278. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Karimian MS, Pirro M, Johnston TP, Majeed M and Sahebkar A: Curcumin and endothelial function: Evidence and mechanisms of protective effects. Curr Pharm Des. 23:2462–2473. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Jha A, Mohapatra PP, AlHarbi SA and Jahan N: Curcumin: Not so spicy after all. Mini Rev Med Chem. 17:1425–1434. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Peng SF, Lee CY, Hour MJ, Tsai SC, Kuo DH, Chen FA, Shieh PC and Yang JS: Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway. Int J Oncol. 44:238–246. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Borges GÁ, Rêgo DF, Assad DX, Coletta RD, De Luca Canto G and Guerra EN: In vivo and in vitro effects of curcumin on head and neck carcinoma: A systematic review. J Oral Pathol Med. 46:3–20. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Vander Broek R, Snow GE, Chen Z and Van Waes C: Chemoprevention of head and neck squamous cell carcinoma through inhibition of NF-kB signaling. Oral Oncol. 50:930–941. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Agrawal DK and Mishra PK: Curcumin and its analogues: Potential anticancer agents. Med Res Rev. 30:818–860. 2010.PubMed/NCBI

29 

Lin JK: Molecular targets of curcumin. Adv Exp Med Biol. 595:227–243. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Fetoni AR, Paciello F, Mezzogori D, Rolesi R, Eramo SL, Paludetti G and Troiani D: Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: The role of curcumin on pSTAT3 and Nrf-2 signalling. Br J Cancer. 113:1434–1444. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Sivanantham B, Sethuraman S and Krishnan UM: Combinatorial effects of curcumin with an anti-neoplastic agent on head and neck squamous cell carcinoma through the regulation of EGFR-ERK1/2 and apoptotic signaling pathways. ACS Comb Sci. 18:22–35. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Gosepath EM, Eckstein N, Hamacher A, Servan K, von Jonquieres G, Lage H, Györffy B, Royer HD and Kassack MU: Acquired cisplatin resistance in the head-neck cancer cell line Cal27 is associated with decreased DKK1 expression and can partially be reversed by overexpression of DKK1. Int J Cancer. 123:2013–2019. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Chang PY, Peng SF, Lee CY, Lu CC, Tsai SC, Shieh TM, Wu TS, Tu MG, Chen MY and Yang JS: Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells. Int J Oncol. 43:1141–1150. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Lee MR, Lin C, Lu CC, Kuo SC, Tsao JW, Juan YN, Chiu HY, Lee FY, Yang JS and Tsai FJ: YC-1 induces G0/G1 phase arrest and mitochondria-dependent apoptosis in cisplatin-resistant human oral cancer CAR cells. Biomedicine (Taipei). 7:122017. View Article : Google Scholar : PubMed/NCBI

35 

Lu CC, Yang JS, Chiang JH, Hour MJ, Lin KL, Lee TH and Chung JG: Cell death caused by quinazolinone HMJ-38 challenge in oral carcinoma CAL 27 cells: Dissections of endoplasmic reticulum stress, mitochondrial dysfunction and tumor xenografts. Biochim Biophys Acta. 1840:2310–2320. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Xu Y, Xin Y, Diao Y, Lu C, Fu J, Luo L and Yin Z: Synergistic effects of apigenin and paclitaxel on apoptosis of cancer cells. PLoS One. 6:e291692011. View Article : Google Scholar : PubMed/NCBI

37 

Lu CC, Huang BR, Liao PJ and Yen GC: Ursolic acid triggers nonprogrammed death (necrosis) in human glioblastoma multiforme DBTRG-05MG cells through MPT pore opening and ATP decline. Mol Nutr Food Res. 58:2146–2156. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Chiang JH, Yang JS, Lu CC, Hour MJ, Chang SJ, Lee TH and Chung JG: Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulated Fas/death receptor signaling. Toxicol Appl Pharmacol. 269:150–162. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Ma YS, Weng SW, Lin MW, Lu CC, Chiang JH, Yang JS, Lai KC, Lin JP, Tang NY, Lin JG and Chung JG: Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: Roles of apoptotic cell death and LS1034 tumor xenografts model. Food Chem Toxicol. 50:1271–1278. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Huang WW, Chiu YJ, Fan MJ, Lu HF, Yeh HF, Li KH, Chen PY, Chung JG and Yang JS: Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells. Mol Nutr Food Res. 54:1585–1595. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Grossi V, Peserico A, Tezil T and Simone C: p38alpha MAPK pathway: A key factor in colorectal cancer therapy and chemoresistance. World J Gastroenterol. 20:9744–9758. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Nibu KI, Hayashi R, Asakage T, Ojiri H, Kimata Y, Kodaira T, Nagao T, Nakashima T, Fujii T, Fujii H, et al: Japanese clinical practice guideline for head and neck cancer. Auris Nasus Larynx. 44:375–380. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Brockstein BE and Vokes EE: Oral chemotherapy in head and neck cancer. Drugs. 58 Suppl 3:S91–S97. 1999. View Article : Google Scholar

44 

Köberle B, Tomicic MT, Usanova S and Kaina B: Cisplatin resistance: Preclinical findings and clinical implications. Biochim Biophys Acta. 1806:172–182. 2010.PubMed/NCBI

45 

Carlsson L, Bratman SV, Siu LL and Spreafico A: The cisplatin total dose and concomitant radiation in locoregionally advanced head and neck cancer: Any recent evidence for dose efficacy? Curr Treat Options Oncol. 18:392017. View Article : Google Scholar : PubMed/NCBI

46 

Wang C, Liu XQ, Hou JS, Wang JN and Huang HZ: Molecular mechanisms of chemoresistance in oral cancer. Chin J Dent Res. 19:25–33. 2016.PubMed/NCBI

47 

Dasari S and Tchounwou PB: Cisplatin in cancer therapy: Molecular mechanisms of action. Eur J Pharmacol. 740:364–378. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Brozovic A: The relationship between platinum drug resistance and epithelial-mesenchymal transition. Arch Toxicol. 91:605–619. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Alorabi M, Shonka NA and Ganti AK: EGFR monoclonal antibodies in locally advanced head and neck squamous cell carcinoma: What is their current role? Crit Rev Oncol Hematol. 99:170–179. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Kuroda H, Takeno M, Murakami S, Miyazawa N, Kaneko T and Ishigatsubo Y: Inhibition of heme oxygenase-1 with an epidermal growth factor receptor inhibitor and cisplatin decreases proliferation of lung cancer A549 cells. Lung Cancer. 67:31–36. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Seo Y, Ishii Y, Ochiai H, Fukuda K, Akimoto S, Hayashida T, Okabayashi K, Tsuruta M, Hasegawa H and Kitagawa Y: Cetuximab-mediated ADCC activity is correlated with the cell surface expression level of EGFR but not with the KRAS/BRAF mutational status in colorectal cancer. Oncol Rep. 31:2115–2122. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Kondo N, Tsukuda M, Sakakibara A, Takahashi H, Hyakusoku H, Komatsu M, Niho T, Nakazaki K and Toth G: Combined molecular targeted drug therapy for EGFR and HER-2 in head and neck squamous cell carcinoma cell lines. Int J Oncol. 40:1805–1812. 2012.PubMed/NCBI

53 

Ji JL, Huang XF and Zhu HL: Curcumin and its formulations: Potential anti-cancer agents. Anticancer Agents Med Chem. 12:210–218. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Shehzad A, Wahid F and Lee YS: Curcumin in cancer chemoprevention: Molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm (Weinheim). 343:489–499. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Qadir MI, Naqvi ST and Muhammad SA: Curcumin: A polyphenol with molecular targets for cancer control. Asian Pac J Cancer Prev. 17:2735–2739. 2016.PubMed/NCBI

56 

Weisberg S, Leibel R and Tortoriello DV: Proteasome inhibitors, including curcumin, improve pancreatic β-cell function and insulin sensitivity in diabetic mice. Nutr Diabetes. 6:e2052016. View Article : Google Scholar : PubMed/NCBI

57 

Lee JY, Lee YM, Chang GC, Yu SL, Hsieh WY, Chen JJ, Chen HW and Yang PC: Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: The versatile adjuvant for gefitinib therapy. PLoS One. 6:e237562011. View Article : Google Scholar : PubMed/NCBI

58 

Son DJ, Hong JE, Ban JO, Park JH, Lee HL, Gu SM, Hwang JY, Jung MH, Lee DW, Han SB and Hong JT: Synergistic inhibitory effects of cetuximab and cisplatin on human colon cancer cell growth via inhibition of the ERK-dependent EGF receptor signaling pathway. Biomed Res Int. 2015:3975632015. View Article : Google Scholar : PubMed/NCBI

59 

Li X, Lu Y, Pan T and Fan Z: Roles of autophagy in cetuximab-mediated cancer therapy against EGFR. Autophagy. 6:1066–1077. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Douglass BJ and Clouatre DL: Beyond yellow curry: Assessing commercial curcumin absorption technologies. J Am Coll Nutr. 34:347–358. 2015. View Article : Google Scholar : PubMed/NCBI

61 

Chang LC, Hsieh MT, Yang JS, Lu CC, Tsai FJ, Tsao JW, Chiu YJ, Kuo SC and Lee KH: Effect of bis(hydroxymethyl) alkanoate curcuminoid derivative MTH-3 on cell cycle arrest, apoptotic and autophagic pathway in triple-negative breast adenocarcinoma MDA-MB-231 cells: An in vitro study. Int J Oncol. 52:67–76. 2018.PubMed/NCBI

62 

Hsieh MT, Chang LC, Hung HY, Lin HY, Shih MH, Tsai CH, Kuo SC and Lee KH: New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo. Eur J Med Chem. 131:141–151. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen CF, Lu CC, Chiang JH, Chiu HY, Yang JS, Lee CY, Way TD and Huang HJ: Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process. Oncol Lett 16: 6323-6330, 2018.
APA
Chen, C., Lu, C., Chiang, J., Chiu, H., Yang, J., Lee, C. ... Huang, H. (2018). Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process. Oncology Letters, 16, 6323-6330. https://doi.org/10.3892/ol.2018.9418
MLA
Chen, C., Lu, C., Chiang, J., Chiu, H., Yang, J., Lee, C., Way, T., Huang, H."Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process". Oncology Letters 16.5 (2018): 6323-6330.
Chicago
Chen, C., Lu, C., Chiang, J., Chiu, H., Yang, J., Lee, C., Way, T., Huang, H."Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process". Oncology Letters 16, no. 5 (2018): 6323-6330. https://doi.org/10.3892/ol.2018.9418
Copy and paste a formatted citation
x
Spandidos Publications style
Chen CF, Lu CC, Chiang JH, Chiu HY, Yang JS, Lee CY, Way TD and Huang HJ: Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process. Oncol Lett 16: 6323-6330, 2018.
APA
Chen, C., Lu, C., Chiang, J., Chiu, H., Yang, J., Lee, C. ... Huang, H. (2018). Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process. Oncology Letters, 16, 6323-6330. https://doi.org/10.3892/ol.2018.9418
MLA
Chen, C., Lu, C., Chiang, J., Chiu, H., Yang, J., Lee, C., Way, T., Huang, H."Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process". Oncology Letters 16.5 (2018): 6323-6330.
Chicago
Chen, C., Lu, C., Chiang, J., Chiu, H., Yang, J., Lee, C., Way, T., Huang, H."Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process". Oncology Letters 16, no. 5 (2018): 6323-6330. https://doi.org/10.3892/ol.2018.9418
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team