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Article Open Access

Retrospective study of regorafenib and trifluridine/tipiracil efficacy as a third‑line or later chemotherapy regimen for refractory metastatic colorectal cancer

  • Authors:
    • Akira Tanaka
    • Sotaro Sadahiro
    • Toshiyuki Suzuki
    • Kazutake Okada
    • Gota Saito
    • Hiroshi Miyakita
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259‑1193, Japan
    Copyright: © Tanaka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6589-6597
    |
    Published online on: September 7, 2018
       https://doi.org/10.3892/ol.2018.9421
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Abstract

Regorafenib and trifluridine/tipiracil (TAS-102) are novel antitumor agents for patients with refractory metastatic colorectal cancer. However, it is unclear which patients may derive a survival benefit from these drugs in real‑life clinical practice. We evaluated retrospectively the efficacy and safety of regorafenib and TAS‑102 at a single institution between June 2013 and November 2015. Cox regression analysis was carried out to obtain predictive scores (the nearest integers of hazard ratio) for survival benefit. Forty‑four patients treated with regorafenib or TAS‑102 were included in the analysis; among them, 17 received crossover treatment. The median overall survival (OS) was 9.1 months for regorafenib and 9.3 months for TAS‑102, and the corresponding values after crossover were 7.1 and 5.3 months, respectively. OS was not correlated to relative dose intensity, but was proportional to the total administered dose of each drug. Adverse events were tolerable even after crossover. We identified three variables as significant for prediction of OS with good discrimination (C‑statistic=0.70): Poor Eastern Cooperative Oncology Group performance status, time since diagnosis of metastatic disease ≤18 months, and previous chemotherapy continued ≥2 months beyond progression were all predictors of poor OS. Regorafenib and TAS‑102 can be recommended for patients with better performance status and slow progression of metastatic disease. Optimal survival benefit was provided by prompt administration of either drug after failure of previous chemotherapy, with flexible titration to the optimal dose for each individual patient.
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Copy and paste a formatted citation
Spandidos Publications style
Tanaka A, Sadahiro S, Suzuki T, Okada K, Saito G and Miyakita H: Retrospective study of regorafenib and trifluridine/tipiracil efficacy as a third‑line or later chemotherapy regimen for refractory metastatic colorectal cancer. Oncol Lett 16: 6589-6597, 2018.
APA
Tanaka, A., Sadahiro, S., Suzuki, T., Okada, K., Saito, G., & Miyakita, H. (2018). Retrospective study of regorafenib and trifluridine/tipiracil efficacy as a third‑line or later chemotherapy regimen for refractory metastatic colorectal cancer. Oncology Letters, 16, 6589-6597. https://doi.org/10.3892/ol.2018.9421
MLA
Tanaka, A., Sadahiro, S., Suzuki, T., Okada, K., Saito, G., Miyakita, H."Retrospective study of regorafenib and trifluridine/tipiracil efficacy as a third‑line or later chemotherapy regimen for refractory metastatic colorectal cancer". Oncology Letters 16.5 (2018): 6589-6597.
Chicago
Tanaka, A., Sadahiro, S., Suzuki, T., Okada, K., Saito, G., Miyakita, H."Retrospective study of regorafenib and trifluridine/tipiracil efficacy as a third‑line or later chemotherapy regimen for refractory metastatic colorectal cancer". Oncology Letters 16, no. 5 (2018): 6589-6597. https://doi.org/10.3892/ol.2018.9421
Copy and paste a formatted citation
x
Spandidos Publications style
Tanaka A, Sadahiro S, Suzuki T, Okada K, Saito G and Miyakita H: Retrospective study of regorafenib and trifluridine/tipiracil efficacy as a third‑line or later chemotherapy regimen for refractory metastatic colorectal cancer. Oncol Lett 16: 6589-6597, 2018.
APA
Tanaka, A., Sadahiro, S., Suzuki, T., Okada, K., Saito, G., & Miyakita, H. (2018). Retrospective study of regorafenib and trifluridine/tipiracil efficacy as a third‑line or later chemotherapy regimen for refractory metastatic colorectal cancer. Oncology Letters, 16, 6589-6597. https://doi.org/10.3892/ol.2018.9421
MLA
Tanaka, A., Sadahiro, S., Suzuki, T., Okada, K., Saito, G., Miyakita, H."Retrospective study of regorafenib and trifluridine/tipiracil efficacy as a third‑line or later chemotherapy regimen for refractory metastatic colorectal cancer". Oncology Letters 16.5 (2018): 6589-6597.
Chicago
Tanaka, A., Sadahiro, S., Suzuki, T., Okada, K., Saito, G., Miyakita, H."Retrospective study of regorafenib and trifluridine/tipiracil efficacy as a third‑line or later chemotherapy regimen for refractory metastatic colorectal cancer". Oncology Letters 16, no. 5 (2018): 6589-6597. https://doi.org/10.3892/ol.2018.9421
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