Transition of serum cytokines following pancreaticoduodenectomy: A subsidiary study of JAPAN‑PD

Maeda,Hiromichi; Okada,Ken‑Ichi; Fujii,Tsutomu; Oba,Mari S.; Kawai,Manabu; Hirono,Seiko; Kodera,Yasuhiro; Sho,Masayuki; Akahori,Takahiro; Shimizu,Yasuhiro; Ambo,Yoshiyasu; Kondo,Naru; Murakami,Yoshiaki; Ohuchida,Jiro; Eguchi,Hidetoshi; Nagano,Hiroaki; Sakamoto,Junichi; Yamaue,Hiroki

doi:10.3892/ol.2018.9422

Transition of serum cytokines following pancreaticoduodenectomy: A subsidiary study of JAPAN‑PD

Authors:
- Hiromichi Maeda
- Ken‑Ichi Okada
- Tsutomu Fujii
- Mari S. Oba
- Manabu Kawai
- Seiko Hirono
- Yasuhiro Kodera
- Masayuki Sho
- Takahiro Akahori
- Yasuhiro Shimizu
- Yoshiyasu Ambo
- Naru Kondo
- Yoshiaki Murakami
- Jiro Ohuchida
- Hidetoshi Eguchi
- Hiroaki Nagano
- Junichi Sakamoto
- Hiroki Yamaue
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Affiliations: Cancer Treatment Center, Kochi Medical School, Nankoku, Kochi 783‑8505, Japan, Second Department of Surgery, Wakayama Medical University, Wakayama, Wakayama 641‑8510, Japan, Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8560, Japan, Department of Medical Statistics Faculty of Medicine, Toho University, Tokyo 143‑8540, Japan, Department of Surgery, Nara Medical University, Kashihara, Nara 634‑8521, Japan, Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan, Department of Surgery, Teine‑Keijinkai Hospital, Sapporo, Hokkaido 006‑8555, Japan, Department of Surgery, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima 734‑8553, Japan, Department of Surgery, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Miyazaki 880‑8510, Japan, Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565‑0871, Japan, Tokai Central Hospital, Kakamigahara, Gifu 504‑8601, Japan
Published online on: September 7, 2018 https://doi.org/10.3892/ol.2018.9422
Pages: 6847-6853

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Abstract

Our previous study aimed to examine the effect of TJ-100, a widely used herbal medicine, on intestinal function following pancreaticoduodenectomy (PD) in a multicenter, randomized, double‑blinded, placebo‑controlled manner (JAPAN‑PD study). This concomitant study investigated the effect of TJ‑100 on serum cytokine levels in patients who underwent PD. Due to the fact that several clinical variables can affect the absolute values of baseline serum cytokine levels, the ratios of the cytokine levels on postoperative day (POD)3 to those on POD1 were also used for analysis. The present study enrolled 180/224 randomized patients, of whom 91 received TJ‑100 and 89 received placebo. As the main findings of the analysis, Wilcoxon signed‑rank test revealed no significant difference in the levels of serum cytokines between the groups; however, patients in the TJ‑100 group without severe inflammatory complications exhibited significantly higher ratios of interleukin (IL)‑4 (n=123), IL‑9 (n=72), IL‑10 (n=97), PDGF‑BB (n=143) and tumor necrosis factor‑α (n=135), compared with patients in the Placebo Group (P<0.05). According to the results of the present study, TJ‑100 has an effect on the change in serum cytokine levels from POD1 to POD3 following PD. However, the role of different transition pattern of cytokines in postoperative recovery following PD has to be investigated by further mechanical studies focusing on these extracted cytokines (ClinicalTrials.gov; no. NCT01607307; May 30, 2012).

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