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miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2

  • Authors:
    • Haijian Zhang
    • Meijuan Jiang
    • Qingjun Liu
    • Zhixing Han
    • Yuqian Zhao
    • Shiqi Ji
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China, Department of Neurology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6355-6360
    |
    Published online on: September 12, 2018
       https://doi.org/10.3892/ol.2018.9436
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Abstract

MicroRNA-145-5p (miR-145-5p) is found to be involved in tumor development and progression. However, there are few studies on the effects of miR-145-5p on bladder cancer (BC). The role of miR-145-5p in BC was predicted by analysis of cell proliferation and migration in this study. The miR-145-5p and transgelin-2 (TAGLN2) expressions were evaluated via reverse transcription-quantitative PCR (RT-qPCR) or western blot analysis. The MTT and Transwell assay assessed cell proliferation and migration. TAGLN2 targeted to miR-145-5p was determined using luciferase assays. The results showed that the miR-145-5p downregulation was found in BC. miR-145-5p overexpression inhibited cell proliferation and migration in BC. Moreover, miR-145-5p directly targeted TAGLN2, and TAGLN2 expression was increased in BC. In addition, the high expression of TAGLN2 promoted cell proliferation and migration in BC. miR-145-5p appeared to regulate TAGLN2 in BC, and it also inhibited the cell proliferation and migration. The novel miR-145-5p/TAGLN2 axis may provide new therapeutic implications for BC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Jiang M, Liu Q, Han Z, Zhao Y and Ji S: miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2. Oncol Lett 16: 6355-6360, 2018.
APA
Zhang, H., Jiang, M., Liu, Q., Han, Z., Zhao, Y., & Ji, S. (2018). miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2. Oncology Letters, 16, 6355-6360. https://doi.org/10.3892/ol.2018.9436
MLA
Zhang, H., Jiang, M., Liu, Q., Han, Z., Zhao, Y., Ji, S."miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2". Oncology Letters 16.5 (2018): 6355-6360.
Chicago
Zhang, H., Jiang, M., Liu, Q., Han, Z., Zhao, Y., Ji, S."miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2". Oncology Letters 16, no. 5 (2018): 6355-6360. https://doi.org/10.3892/ol.2018.9436
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Jiang M, Liu Q, Han Z, Zhao Y and Ji S: miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2. Oncol Lett 16: 6355-6360, 2018.
APA
Zhang, H., Jiang, M., Liu, Q., Han, Z., Zhao, Y., & Ji, S. (2018). miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2. Oncology Letters, 16, 6355-6360. https://doi.org/10.3892/ol.2018.9436
MLA
Zhang, H., Jiang, M., Liu, Q., Han, Z., Zhao, Y., Ji, S."miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2". Oncology Letters 16.5 (2018): 6355-6360.
Chicago
Zhang, H., Jiang, M., Liu, Q., Han, Z., Zhao, Y., Ji, S."miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2". Oncology Letters 16, no. 5 (2018): 6355-6360. https://doi.org/10.3892/ol.2018.9436
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