Open Access

Ethnicity based variation in expression of E‑cadherin in patients with squamous cell carcinoma of the oral tongue

  • Authors:
    • Nicola Sgaramella
    • Torben Wilms
    • Linda Boldrup
    • Lotta Loljung
    • Xiaolian Gu
    • Philip J. Coates
    • Petra Hassellöf
    • Luigi Califano
    • Lorenzo Lo Muzio
    • Robin Fåhraeus
    • Lena Norberg Spaak
    • Renato Franco
    • Gianpaolo Tartaro
    • Giuseppe Colella
    • Mario Santagata
    • Giovanni Dell'Aversana Orabona
    • Fabrizio Chirico
    • Karin Danielsson
    • Giuseppe Troiano
    • Fatima Ardito
    • Karin Nylander
  • View Affiliations

  • Published online on: September 18, 2018     https://doi.org/10.3892/ol.2018.9452
  • Pages: 6603-6607
  • Copyright: © Sgaramella et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The oral tongue is the most common site for tumours within the oral cavity. Despite intense research, there has been no improvement in the survival rate for patients with oral tongue squamous cell carcinoma (OTSCC) during the last decades. Differences between oral cancer patients based on ethno‑geographical distribution have been reported. The present study used immunohistochemistry to evaluate commonly used markers of cancer cell phenotypes, E‑cadherin, β‑catenin and cytokeratins 5 and 19, in 120 patients with OTSCC. To evaluate the impact of ethnicity, patients from Sweden and Italy were included. A higher proportion of Swedish patients exhibited high expression of E‑cadherin in their tumours (P=0.039), and high levels of E‑cadherin in Swedish OTSCC patients that had succumbed to their disease were associated with poor prognosis. These data demonstrated differences in the pathological characteristics of OTSCC between two different European populations. The findings emphasise the need to take ethnicity/geographical location of patients into account when comparing results from different studies of OTSCC.

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November 2018
Volume 16 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Sgaramella, N., Wilms, T., Boldrup, L., Loljung, L., Gu, X., Coates, P.J. ... Nylander, K. (2018). Ethnicity based variation in expression of E‑cadherin in patients with squamous cell carcinoma of the oral tongue. Oncology Letters, 16, 6603-6607. https://doi.org/10.3892/ol.2018.9452
MLA
Sgaramella, N., Wilms, T., Boldrup, L., Loljung, L., Gu, X., Coates, P. J., Hassellöf, P., Califano, L., Lo Muzio, L., Fåhraeus, R., Norberg Spaak, L., Franco, R., Tartaro, G., Colella, G., Santagata, M., Dell'Aversana Orabona, G., Chirico, F., Danielsson, K., Troiano, G., Ardito, F., Nylander, K."Ethnicity based variation in expression of E‑cadherin in patients with squamous cell carcinoma of the oral tongue". Oncology Letters 16.5 (2018): 6603-6607.
Chicago
Sgaramella, N., Wilms, T., Boldrup, L., Loljung, L., Gu, X., Coates, P. J., Hassellöf, P., Califano, L., Lo Muzio, L., Fåhraeus, R., Norberg Spaak, L., Franco, R., Tartaro, G., Colella, G., Santagata, M., Dell'Aversana Orabona, G., Chirico, F., Danielsson, K., Troiano, G., Ardito, F., Nylander, K."Ethnicity based variation in expression of E‑cadherin in patients with squamous cell carcinoma of the oral tongue". Oncology Letters 16, no. 5 (2018): 6603-6607. https://doi.org/10.3892/ol.2018.9452