Ethnicity based variation in expression of E‑cadherin in patients with squamous cell carcinoma of the oral tongue

Sgaramella,Nicola; Wilms,Torben; Boldrup,Linda; Loljung,Lotta; Gu,Xiaolian; Coates,Philip  J.; Hassellöf,Petra; Califano,Luigi; Lo Muzio,Lorenzo; Fåhraeus,Robin; Norberg Spaak,Lena; Franco,Renato; Tartaro,Gianpaolo; Colella,Giuseppe; Santagata,Mario; Dell'Aversana Orabona,Giovanni; Chirico,Fabrizio; Danielsson,Karin; Troiano,Giuseppe; Ardito,Fatima; Nylander,Karin

doi:10.3892/ol.2018.9452

November-2018 Volume 16 Issue 5

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November-2018 Volume 16 Issue 5

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Article Open Access

Ethnicity based variation in expression of E‑cadherin in patients with squamous cell carcinoma of the oral tongue

Authors:
- Nicola Sgaramella
- Torben Wilms
- Linda Boldrup
- Lotta Loljung
- Xiaolian Gu
- Philip J. Coates
- Petra Hassellöf
- Luigi Califano
- Lorenzo Lo Muzio
- Robin Fåhraeus
- Lena Norberg Spaak
- Renato Franco
- Gianpaolo Tartaro
- Giuseppe Colella
- Mario Santagata
- Giovanni Dell'Aversana Orabona
- Fabrizio Chirico
- Karin Danielsson
- Giuseppe Troiano
- Fatima Ardito
- Karin Nylander
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Affiliations: Department of Medical Biosciences, Umeå University, SE‑901 85 Umeå, Sweden, Department of Clinical Sciences/ENT, Umeå University, SE‑901 85 Umeå, Sweden, RECAMO, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic, Department of Neuroscience Reproductive and Dentistry Sciences, University of Naples Federico II, I‑801 38 Naples, Italy, Department of Clinical and Experimental Medicine, University of Foggia, I‑71122 Foggia, Italy, Dipartimento Universitario di Anatomia Patologica, Second University of Naples, Piazza Miraglia, I-801 38 Naples, Italy, Multidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples, I‑801 38 Naples, Italy, Department of Odontology, Umeå University, SE‑901 85 Umeå, Sweden

Copyright: © Sgaramella et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 6603-6607
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Published online on: September 18, 2018

https://doi.org/10.3892/ol.2018.9452
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Abstract

The oral tongue is the most common site for tumours within the oral cavity. Despite intense research, there has been no improvement in the survival rate for patients with oral tongue squamous cell carcinoma (OTSCC) during the last decades. Differences between oral cancer patients based on ethno‑geographical distribution have been reported. The present study used immunohistochemistry to evaluate commonly used markers of cancer cell phenotypes, E‑cadherin, β‑catenin and cytokeratins 5 and 19, in 120 patients with OTSCC. To evaluate the impact of ethnicity, patients from Sweden and Italy were included. A higher proportion of Swedish patients exhibited high expression of E‑cadherin in their tumours (P=0.039), and high levels of E‑cadherin in Swedish OTSCC patients that had succumbed to their disease were associated with poor prognosis. These data demonstrated differences in the pathological characteristics of OTSCC between two different European populations. The findings emphasise the need to take ethnicity/geographical location of patients into account when comparing results from different studies of OTSCC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Ethnicity based variation in expression of E‑cadherin in patients with squamous cell carcinoma of the oral tongue

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