Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Filamin A inhibits tumor progression through regulating BRCA1 expression in human breast cancer

  • Authors:
    • Yundi Guo
    • Ming Li
    • Guanghui Bai
    • Xiaoning Li
    • Zhongwen Sun
    • Jie Yang
    • Lu Wang
    • Jing Sun
  • View Affiliations / Copyright

    Affiliations: Suzhou Vocational Health College, Suzhou, Jiangsu 215009, P.R. China, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu 215000, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6261-6266
    |
    Published online on: September 20, 2018
       https://doi.org/10.3892/ol.2018.9473
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Filamin A (FlnA) is an actin cross‑linking protein. Previous studies have demonstrated its role in tumor progression in a wide range of cancer types. It has been reported that FlnA interacts with the DNA damage response protein, breast cancer gene 1 (BRCA1), which is a tumor suppressor gene. However, to the best of our knowledge, there are no studies evaluating the association of these genes in human carcinomas. In the present study, the immunohistochemistry of a tissue microarray was used to investigate the clinical significance of FlnA and BRCA1 expression in pathological specimens collected from 424 patients treated for breast cancer. In addition, FlnA and BRCA1 expression was downregulated in the breast cancer cell line, MCF‑7, through FlnA RNA interference. FlnA expression was exhibited by cancer tissues collected from 137 patients with breast cancer, which also exhibited high expression of BRCA1 and were associated with a relatively long survival time. A significant association was identified between FlnA protein expression and tumor size, and between FlnA protein expression and progesterone receptor expression. These results suggest that BRCA1 expression could be regulated by FlnA in the breast cancer cell line, MCF‑7. Overall, the present study demonstrates that FlnA expression was associated with BRAC1 expression and tumor size in breast cancer, which provides important implications for future study of FlnA in the progression of human breast cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Feng Y and Walsh CA: The many faces of filamin: A versatile molecular scaffold for cell motility and signalling. Nat Cell Biol. 6:1034–1038. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Popowicz GM, Schleicher M, Noegel AA and Holak TA: Filamins: Promiscuous organizers of the cytoskeleton. Trends Biochem Sci. 31:411–419. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Meng X, Yuan Y, Maestas A and Shen Z: Recovery from DNA damage-induced G2 arrest requires actin-binding protein filamin-A/actin-binding protein 280. J Biol Chem. 279:6098–6105. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Duval D, Lardeux A, Le Tourneau T, Norris RA, Markwald RR, Sauzeau V, Probst V, Le Marec H, Levine R, Schott JJ and Merot J: Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation. Biochim Biophys Acta. 1843:234–244. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Nakamura F, Pudas R, Heikkinen O, Permi P, Kilpeläinen I, Munday AD, Hartwig JH, Stossel TP and Ylänne J: The structure of the GPIb-filamin A complex. Blood. 107:1925–3192. 2016. View Article : Google Scholar

6 

Shao QQ, Zhang TP, Zhao WJ, Liu ZW, You L, Zhou L, Guo JC and Zhao YP: Filamin A: Insights into its exact role in cancers. Pathol Oncol Res. 22:245–252. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Yue J, Lu H, Liu J, Berwick M and Shen Z: Filamin-A as a marker and target for DNA damage based cancer therapy. DNA Repair (Amst). 11:192–200. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Savoy RM and Ghosh PM: The dual role of filamin A in cancer: Can't live with (too much of) it, can't live without it. Endocr Relat Cancer. 20:R341–R356. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Ford D, Easton DF, Bishop DT, Narod SA and Goldgar DE: Risks of cancer in BRCA1-mutation carriers. Breast cancer linkage consortium. Lancet. 343:692–695. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Easton DF, Bishop DT, Ford D and Crockford GP: Genetic linkage analysis in familial breast and ovarian cancer: Results from 214 families. The breast cancer linkage consortium. Am J Hum Genet. 52:678–701. 1993.PubMed/NCBI

11 

Gowen LC, Johnson BL, Latour AM, Sulik KK and Koller BH: Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet. 12:191–194. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Velkova A, Carvalho MA, Johnson JO, Tavtigian SV and Monteiro AN: Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair. Cell Cycle. 9:1421–1433. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Benson DA, Karsch-Mizrachi I, Lipman DJ, Ostell J and Wheeler DL: GenBank. Nucleic Acids Res. 33:D34–D38. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Hartwig JH and Stossel TP: Isolation and properties of actin, myosin, and a new actinbinding protein in rabbit alveolar macrophages. J Biol Chem. 250:5696–5705. 1975.PubMed/NCBI

16 

Nakamura F, Stossel TP and Hartwig JH: The filamins: Organizers of cell structure and function. Cell Adh Migr. 5:160–169. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Flanagan LA, Chou J, Falet H, Neujahr R, Hartwig JH and Stossel TP: Filamin A the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J Cell Biol. 155:511–517. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Ai J, Huang H, Lv X, Tang Z, Chen M, Chen T, Duan W, Sun H, Li Q, Tan R, et al: FLNA and PGK1 are two potential markers for progression in hepatocellular carcinoma. Cell Physiol Biochem. 27:207–216. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Lin JF, Xu J, Tian HY, Gao X, Chen QX, Gu Q, Xu GJ, Song JD and Zhao FK: Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis. Int J Cancer. 121:2596–2605. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Jiang X, Yue J, Lu H, Campbell N, Yang Q, Lan S, Haffty BG, Yuan C and Shen Z: Inhibition of filamin-A reduces cancer metastatic potential. Int J Biol Sci. 9:67–77. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Alper O, Stetler-Stevenson WG, Harris LN, Leitner WW, Ozdemirli M, Hartmann D, Raffeld M, Abu-Asab M, Byers S, Zhuang Z, et al: Novel anti-filamin-A antibody detects a secreted variant of filamin-A in plasma from patients with breast carcinoma and high-grade astrocytoma. Cancer Sci. 100:1748–1756. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Tian HM, Liu XH, Han W, Zhao LL, Yuan B and Yuan CJ: Differential expression of filamin A and its clinical significance in breast cancer. Oncol Lett. 6:681–686. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM and Ding W: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 266:66–71. 1994. View Article : Google Scholar : PubMed/NCBI

24 

Kim KM, Moon YJ, Park SH, Park HJ, Wang SI, Park HS, Lee H, Kwon KS, Moon WS, Lee DG, et al: Individual and combined expression of DNA damage response molecules PARP1, gammaH2AX, BRCA1, and BRCA2 predict shorter survival of soft tissue sarcoma patients. PLoS One. 11:e01631932016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Guo Y, Li M, Bai G, Li X, Sun Z, Yang J, Wang L and Sun J: Filamin A inhibits tumor progression through regulating BRCA1 expression in human breast cancer. Oncol Lett 16: 6261-6266, 2018.
APA
Guo, Y., Li, M., Bai, G., Li, X., Sun, Z., Yang, J. ... Sun, J. (2018). Filamin A inhibits tumor progression through regulating BRCA1 expression in human breast cancer. Oncology Letters, 16, 6261-6266. https://doi.org/10.3892/ol.2018.9473
MLA
Guo, Y., Li, M., Bai, G., Li, X., Sun, Z., Yang, J., Wang, L., Sun, J."Filamin A inhibits tumor progression through regulating BRCA1 expression in human breast cancer". Oncology Letters 16.5 (2018): 6261-6266.
Chicago
Guo, Y., Li, M., Bai, G., Li, X., Sun, Z., Yang, J., Wang, L., Sun, J."Filamin A inhibits tumor progression through regulating BRCA1 expression in human breast cancer". Oncology Letters 16, no. 5 (2018): 6261-6266. https://doi.org/10.3892/ol.2018.9473
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Y, Li M, Bai G, Li X, Sun Z, Yang J, Wang L and Sun J: Filamin A inhibits tumor progression through regulating BRCA1 expression in human breast cancer. Oncol Lett 16: 6261-6266, 2018.
APA
Guo, Y., Li, M., Bai, G., Li, X., Sun, Z., Yang, J. ... Sun, J. (2018). Filamin A inhibits tumor progression through regulating BRCA1 expression in human breast cancer. Oncology Letters, 16, 6261-6266. https://doi.org/10.3892/ol.2018.9473
MLA
Guo, Y., Li, M., Bai, G., Li, X., Sun, Z., Yang, J., Wang, L., Sun, J."Filamin A inhibits tumor progression through regulating BRCA1 expression in human breast cancer". Oncology Letters 16.5 (2018): 6261-6266.
Chicago
Guo, Y., Li, M., Bai, G., Li, X., Sun, Z., Yang, J., Wang, L., Sun, J."Filamin A inhibits tumor progression through regulating BRCA1 expression in human breast cancer". Oncology Letters 16, no. 5 (2018): 6261-6266. https://doi.org/10.3892/ol.2018.9473
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team