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November-2018 Volume 16 Issue 5

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Case Report

Precursor B cell lymphoid blast crisis of chronic myeloid leukemia with novel chromosomal abnormalities: A case report

  • Authors:
    • Hamoud Al‑Khallaf
    • Hani Alali
    • Adil Alkhatti
  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Laboratory Medicine, King Fahad Specialist Hospital, Dammam 32253, Saudi Arabia, Cancer Institute, Johns Hopkins Aramco Healthcare, Dhahran 34465, Saudi Arabia
  • Pages: 6691-6696
    |
    Published online on: September 25, 2018
       https://doi.org/10.3892/ol.2018.9497
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Abstract

Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder. It is characterized by the presence of the Philadelphia (Ph) chromosome, t(9;22)(q34.1;q11.2), which carries the BCR‑ABL1 fusion gene. Tyrosine kinase inhibitors (TKIs) have markedly changed the treatment approach of CML and have become the first‑line agents for almost all CML patients. However, certain patients experience resistance to these medications, which occurs through several mechanisms, including the accumulation of TKI‑resistant chromosomal abnormalities. The present study reports a case of a 27‑year‑old Saudi male with CML receiving TKI treatment, who presented with precursor B‑cell lymphoblastic crisis demonstrating the presence of the novel combined chromosomal abnormalities; non‑Ph der(22), i(9) and der(20), carrying the BCR‑ABL1 fusion gene. This case report adds to the literature on novel TKI‑resistance‑conferring chromosomal abnormalities and links them to precursor B‑cell lymphoblastic crisis.
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Copy and paste a formatted citation
Spandidos Publications style
Al‑Khallaf H, Alali H and Alkhatti A: Precursor B cell lymphoid blast crisis of chronic myeloid leukemia with novel chromosomal abnormalities: A case report. Oncol Lett 16: 6691-6696, 2018.
APA
Al‑Khallaf, H., Alali, H., & Alkhatti, A. (2018). Precursor B cell lymphoid blast crisis of chronic myeloid leukemia with novel chromosomal abnormalities: A case report. Oncology Letters, 16, 6691-6696. https://doi.org/10.3892/ol.2018.9497
MLA
Al‑Khallaf, H., Alali, H., Alkhatti, A."Precursor B cell lymphoid blast crisis of chronic myeloid leukemia with novel chromosomal abnormalities: A case report". Oncology Letters 16.5 (2018): 6691-6696.
Chicago
Al‑Khallaf, H., Alali, H., Alkhatti, A."Precursor B cell lymphoid blast crisis of chronic myeloid leukemia with novel chromosomal abnormalities: A case report". Oncology Letters 16, no. 5 (2018): 6691-6696. https://doi.org/10.3892/ol.2018.9497
Copy and paste a formatted citation
x
Spandidos Publications style
Al‑Khallaf H, Alali H and Alkhatti A: Precursor B cell lymphoid blast crisis of chronic myeloid leukemia with novel chromosomal abnormalities: A case report. Oncol Lett 16: 6691-6696, 2018.
APA
Al‑Khallaf, H., Alali, H., & Alkhatti, A. (2018). Precursor B cell lymphoid blast crisis of chronic myeloid leukemia with novel chromosomal abnormalities: A case report. Oncology Letters, 16, 6691-6696. https://doi.org/10.3892/ol.2018.9497
MLA
Al‑Khallaf, H., Alali, H., Alkhatti, A."Precursor B cell lymphoid blast crisis of chronic myeloid leukemia with novel chromosomal abnormalities: A case report". Oncology Letters 16.5 (2018): 6691-6696.
Chicago
Al‑Khallaf, H., Alali, H., Alkhatti, A."Precursor B cell lymphoid blast crisis of chronic myeloid leukemia with novel chromosomal abnormalities: A case report". Oncology Letters 16, no. 5 (2018): 6691-6696. https://doi.org/10.3892/ol.2018.9497
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