Role of APLP2 in the prognosis and clinicopathology of renal cell carcinoma

Gao,Lijian; Zhao,Hongda; Zhang,Dongqing; Zhou,Changkuo; Wang,Hui; Ren,Chantao; Liu,Yaxiao; Xia,Yangyang; Shi,Benkang

doi:10.3892/ol.2018.9577

January-2019 Volume 17 Issue 1

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January-2019 Volume 17 Issue 1

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Article

Role of APLP2 in the prognosis and clinicopathology of renal cell carcinoma

Authors:
- Lijian Gao
- Hongda Zhao
- Dongqing Zhang
- Changkuo Zhou
- Hui Wang
- Chantao Ren
- Yaxiao Liu
- Yangyang Xia
- Benkang Shi
View Affiliations / Copyright

Affiliations: Department of Urology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Urology, Dezhou People's Hospital, Dezhou, Shandong 253000, P.R. China
Pages: 508-513
|
Published online on: October 15, 2018

https://doi.org/10.3892/ol.2018.9577
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Abstract

Identifying diagnostic and prognostic biomarkers is crucial for improved guidance of the treatment of renal cell carcinoma (RCC). Amyloid β precursor‑like protein 2 (APLP2) has been determined to serve an important role in the progression of a number of cancer types. However, the expression and significance of APLP2 in RCC remains unknown. In the present study, it was determined that the expression of APLP2 protein (n=10) and mRNA (n=8) expression was significantly decreased in clear cell RCC (CCRCC) tissues compared with that in matched normal renal tissues. The expression level of APLP2 was significantly associated with high Fuhrman grade, high pT stage, and presence of distant metastasis and lymph node metastasis (P<0.05). Multivariate analysis demonstrated that the expression of APLP2 was a significant independent predictor of disease‑specific survival in renal cell carcinoma (P=0.026). Notably, APLP2 expression was significantly associated with disease‑specific survival (P<0.001). APLP2 may be used to potentially predict patient prognosis, and to guide clinical diagnosis and treatment in CCRCC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Role of APLP2 in the prognosis and clinicopathology of renal cell carcinoma

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