Urothelial bladder carcinoma metastasizing to the eye: A systematic review and case report

Giordano,Guido; Olivieri,Nunzio; D'Andrea,Mario   Rosario; Di Raimo,Tania; Manfrin,Erminia; Remo,Andrea; Pancione,Massimo; Brunelli,Matteo; De Santis,Elena; Coppola,Giulia; Scarpa,Aldo; Coppola,Luigi; Parcesepe,Pietro

doi:10.3892/ol.2018.9579

January-2019 Volume 17 Issue 1

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January-2019 Volume 17 Issue 1

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Case Report

Urothelial bladder carcinoma metastasizing to the eye: A systematic review and case report

Authors:
- Guido Giordano
- Nunzio Olivieri
- Mario Rosario D'Andrea
- Tania Di Raimo
- Erminia Manfrin
- Andrea Remo
- Massimo Pancione
- Matteo Brunelli
- Elena De Santis
- Giulia Coppola
- Aldo Scarpa
- Luigi Coppola
- Pietro Parcesepe
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Affiliations: Oncology Division IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, I‑71013 Foggia, Italy, Biology Department, Federico II University of Naples, I‑80134 Naples, Italy, Medical Oncology Unit, San Filippo Neri Hospital, I‑00135 Rome, Italy, Department of Diagnostics and Public Health‑Section of Pathology, University and Hospital Trust of Verona, I‑37134 Verona, Italy, Pathology Unit, Mater Salutis Hospital, ULSS9, Legnago, I‑37045 Verona, Italy, Department of Sciences and Technologies, University of Sannio, I‑82100 Benevento, Italy, Department of Human Anatomy, Sapienza University of Rome, I‑00185 Rome, Italy, UOC of Pathologic Anatomy, San Filippo Neri Hospital, I‑00135 Rome, Italy
Pages: 462-467
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Published online on: October 15, 2018

https://doi.org/10.3892/ol.2018.9579
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Abstract

The eye is a rare site for disseminated malignancies; nevertheless, several tumors may metastasize to ocular structures. Few cases of urothelial and bladder cancer with eye involvement have been described in the literature thus far. The rarity of metastatic ocular localization implies an accurate differential diagnosis among the possible primary tumor sites. However, a specific diagnostic algorithm is not currently available, nor a defined therapeutic approach. Eye metastases are associated with advanced disease and poor prognosis. Physicians should be made aware of the possibility of eye involvement in patients with a past medical history of urothelial bladder cancer associated with ocular symptoms. The present case reports discusses the first documented case, to the best of our knowledge, of an urothelial bladder cancer metastasizing to the retro bulbar region that infiltrates the lacrimal gland. Furthermore, the report provides a systematic qualitative review of the current literature on eye metastases from urothelial bladder cancer using the Preferred Reporting Items for Systematic Reviews and Meta‑Analyses.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Urothelial bladder carcinoma metastasizing to the eye: A systematic review and case report

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