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Review Open Access

Patient‑derived xenograft mouse models: A high fidelity tool for individualized medicine (Review)

  • Authors:
    • Cong Xu
    • Xuelu Li
    • Pixu Liu
    • Man Li
    • Fuwen Luo
  • View Affiliations / Copyright

    Affiliations: Department of Acute Abdomen Surgery, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China, Department of Breast Surgery and Oncology, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning 116044, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3-10
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    Published online on: October 16, 2018
       https://doi.org/10.3892/ol.2018.9583
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Abstract

Patient‑derived xenograft (PDX) mouse models involve the direct transfer of fresh human tumor samples into immunodeficient mice following surgical resection or other medical operations. Gene expression in tumors may be maintained by serial passages of tumors from mouse to mouse. These models aid research into tumor biology and pharmacology without manual manipulation of cell cultures in vitro. and are widely used in individualized cancer therapy/translational medicine, drug development and coclinical trials. PDX models exhibit higher predictive values for clinical outcomes than cell line‑derived xenograft models and genetically engineered mouse models. However, PDX models are associated with certain challenges in clinical application. The present study reviewed current collections of PDX models and assessed the challenges and future directions of this field.
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Copy and paste a formatted citation
Spandidos Publications style
Xu C, Li X, Liu P, Li M and Luo F: Patient‑derived xenograft mouse models: A high fidelity tool for individualized medicine (Review). Oncol Lett 17: 3-10, 2019.
APA
Xu, C., Li, X., Liu, P., Li, M., & Luo, F. (2019). Patient‑derived xenograft mouse models: A high fidelity tool for individualized medicine (Review). Oncology Letters, 17, 3-10. https://doi.org/10.3892/ol.2018.9583
MLA
Xu, C., Li, X., Liu, P., Li, M., Luo, F."Patient‑derived xenograft mouse models: A high fidelity tool for individualized medicine (Review)". Oncology Letters 17.1 (2019): 3-10.
Chicago
Xu, C., Li, X., Liu, P., Li, M., Luo, F."Patient‑derived xenograft mouse models: A high fidelity tool for individualized medicine (Review)". Oncology Letters 17, no. 1 (2019): 3-10. https://doi.org/10.3892/ol.2018.9583
Copy and paste a formatted citation
x
Spandidos Publications style
Xu C, Li X, Liu P, Li M and Luo F: Patient‑derived xenograft mouse models: A high fidelity tool for individualized medicine (Review). Oncol Lett 17: 3-10, 2019.
APA
Xu, C., Li, X., Liu, P., Li, M., & Luo, F. (2019). Patient‑derived xenograft mouse models: A high fidelity tool for individualized medicine (Review). Oncology Letters, 17, 3-10. https://doi.org/10.3892/ol.2018.9583
MLA
Xu, C., Li, X., Liu, P., Li, M., Luo, F."Patient‑derived xenograft mouse models: A high fidelity tool for individualized medicine (Review)". Oncology Letters 17.1 (2019): 3-10.
Chicago
Xu, C., Li, X., Liu, P., Li, M., Luo, F."Patient‑derived xenograft mouse models: A high fidelity tool for individualized medicine (Review)". Oncology Letters 17, no. 1 (2019): 3-10. https://doi.org/10.3892/ol.2018.9583
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