MiR‑506 inhibits cell proliferation, invasion, migration and epithelial‑to‑mesenchymal transition through targeting RWDD4 in human bladder cancer

  • Authors:
    • Yi Hou
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  • Published online on: October 18, 2018     https://doi.org/10.3892/ol.2018.9594
  • Pages: 73-78
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Abstract

MicroRNA (MiR)‑506 serves a vital role in several types of cancer. However, the role of miR‑506 in bladder cancer (BCa) progression remains to be investigated. The present study demonstrated that miR‑506 expression was downregulated in BCa tissues and cell lines. Meanwhile, overexpression of miR‑506 inhibited cell proliferation, migration and invasion. Additionally, upregulated miR‑506 increased E‑cadherin, and reduced N‑cadherin and Vimentin expression levels, as markers of epithelial‑to‑mesenchymal transition. RWD domain containing 4 (RWDD4) was revealed to be a miR506 target in BCa cells, and the downregulation of RWDD4 was found to suppress BCa cell proliferation, migration and invasion. In summary, miR‑506 may suppress the aggressive properties of human BCa cells by targeting RWDD4, and thus may be a novel therapeutic target in human BCa.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hou Y: MiR‑506 inhibits cell proliferation, invasion, migration and epithelial‑to‑mesenchymal transition through targeting RWDD4 in human bladder cancer. Oncol Lett 17: 73-78, 2019
APA
Hou, Y. (2019). MiR‑506 inhibits cell proliferation, invasion, migration and epithelial‑to‑mesenchymal transition through targeting RWDD4 in human bladder cancer. Oncology Letters, 17, 73-78. https://doi.org/10.3892/ol.2018.9594
MLA
Hou, Y."MiR‑506 inhibits cell proliferation, invasion, migration and epithelial‑to‑mesenchymal transition through targeting RWDD4 in human bladder cancer". Oncology Letters 17.1 (2019): 73-78.
Chicago
Hou, Y."MiR‑506 inhibits cell proliferation, invasion, migration and epithelial‑to‑mesenchymal transition through targeting RWDD4 in human bladder cancer". Oncology Letters 17, no. 1 (2019): 73-78. https://doi.org/10.3892/ol.2018.9594