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Case Report Open Access

Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report

  • Authors:
    • Jianguo Wei
    • Jianfeng Yang
    • Wenqing Liang
    • Chunwei Xu
    • Yuanyuan Wen
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China, Department of Radiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China, Department of Pathology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian 350014, P.R. China, Department of Pathology, Zhoushan Hospital of Zhejiang Province, Zhoushan, Zhejiang 316021, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 281-287
    |
    Published online on: October 23, 2018
       https://doi.org/10.3892/ol.2018.9609
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Abstract

Primary thyroid leiomyosarcoma (LMS) is a rare tumor type with an unusual location, the diagnosis is based entirely on histological and immunohistochemical evaluations. In the present study, a rare case of a 74‑year‑old female patient who exhibited a right anterior neck mass for 12 months, which rapidly enlarged for the last 3 months. Ultrasound of the thyroid revealed a 55x42 mm hypoechoic mass with clear margins in the right lobe. Histological examination of the tumor demonstrated malignant spindle cells in interlacing fascicles and whorls. Additionally, nuclear pleomorphism, tumor giant cells, necrosis and abnormal mitotic figures were observed. The immunohistochemistry indicated that the tumor cells were strongly positive for smooth muscle actin, desmin, p53 and vimentin expression, but negative for cytokeratin, epithelial membrane antigen, thyroid transcription factor‑1, paired box‑8, 34βE12, cytokeratin 5/6, cluster of differentiation (CD)117, myoglobin, S100, p16. The final histopathological diagnosis was primary thyroid LMS.
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Copy and paste a formatted citation
Spandidos Publications style
Wei J, Yang J, Liang W, Xu C and Wen Y: Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report. Oncol Lett 17: 281-287, 2019.
APA
Wei, J., Yang, J., Liang, W., Xu, C., & Wen, Y. (2019). Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report. Oncology Letters, 17, 281-287. https://doi.org/10.3892/ol.2018.9609
MLA
Wei, J., Yang, J., Liang, W., Xu, C., Wen, Y."Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report". Oncology Letters 17.1 (2019): 281-287.
Chicago
Wei, J., Yang, J., Liang, W., Xu, C., Wen, Y."Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report". Oncology Letters 17, no. 1 (2019): 281-287. https://doi.org/10.3892/ol.2018.9609
Copy and paste a formatted citation
x
Spandidos Publications style
Wei J, Yang J, Liang W, Xu C and Wen Y: Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report. Oncol Lett 17: 281-287, 2019.
APA
Wei, J., Yang, J., Liang, W., Xu, C., & Wen, Y. (2019). Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report. Oncology Letters, 17, 281-287. https://doi.org/10.3892/ol.2018.9609
MLA
Wei, J., Yang, J., Liang, W., Xu, C., Wen, Y."Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report". Oncology Letters 17.1 (2019): 281-287.
Chicago
Wei, J., Yang, J., Liang, W., Xu, C., Wen, Y."Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report". Oncology Letters 17, no. 1 (2019): 281-287. https://doi.org/10.3892/ol.2018.9609
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