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Prognostic value of inflammation‑based indexes for intrahepatic cholangiocarcinoma following curative resection

  • Authors:
    • Yunhua Wu
    • Fenggang Ren
    • Yichao Chai
    • Zhao Xue
    • Cong Shen
    • Xufeng Zhang
    • Yi Lv
    • Liangshuo Hu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 165-174
    |
    Published online on: October 24, 2018
       https://doi.org/10.3892/ol.2018.9618
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Abstract

It is widely acknowledged that inflammatory indices may serve as effective prognosis indicators for various malignancies. In the present study, the prognostic value of systemic inflammatory biomarkers for patients undergoing curative resection for intrahepatic cholangiocellular carcinoma (ICC) was investigated. Clinical data of ICC patients who underwent curative resection between September 2008 and July 2017 were collected. Inflammatory indictors were analyzed using the Area Under the Receiver Operating Characteristic Curve. Indictors that were significantly associated with the overall survival (OS) were used to establish a systemic inflammation‑based score system and tested via nomogram using R software. The neutrophil To lymphocyte ratio (NLR) and lymphocyte to macrophages ratio (LMR) were significantly associated with the OS and disease‑free survival of the patients. High NLR and low LMR were associated with worse clinicopathological and survival outcomes. The univariate and multivariate analyses indicated that tumor T stage, incisal margin, NLR and LMR were associated with the OS of the patients. The systemic inflammation‑based scoring system based on LMR and NLR demonstrated a stronger discriminatory capacity and may serve as a useful prognostic parameter for patients undergoing curative resection for ICC. Low LMR and high NLR were observed to be associated with poor prognosis and worse clinical outcomes for patients with ICC undergoing curative surgery. A combined inflammation‑based scoring system based on LMR and NLR may effectively predict the outcomes and serve as a novel prognostic predictor for these patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wu Y, Ren F, Chai Y, Xue Z, Shen C, Zhang X, Lv Y and Hu L: Prognostic value of inflammation‑based indexes for intrahepatic cholangiocarcinoma following curative resection. Oncol Lett 17: 165-174, 2019.
APA
Wu, Y., Ren, F., Chai, Y., Xue, Z., Shen, C., Zhang, X. ... Hu, L. (2019). Prognostic value of inflammation‑based indexes for intrahepatic cholangiocarcinoma following curative resection. Oncology Letters, 17, 165-174. https://doi.org/10.3892/ol.2018.9618
MLA
Wu, Y., Ren, F., Chai, Y., Xue, Z., Shen, C., Zhang, X., Lv, Y., Hu, L."Prognostic value of inflammation‑based indexes for intrahepatic cholangiocarcinoma following curative resection". Oncology Letters 17.1 (2019): 165-174.
Chicago
Wu, Y., Ren, F., Chai, Y., Xue, Z., Shen, C., Zhang, X., Lv, Y., Hu, L."Prognostic value of inflammation‑based indexes for intrahepatic cholangiocarcinoma following curative resection". Oncology Letters 17, no. 1 (2019): 165-174. https://doi.org/10.3892/ol.2018.9618
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Y, Ren F, Chai Y, Xue Z, Shen C, Zhang X, Lv Y and Hu L: Prognostic value of inflammation‑based indexes for intrahepatic cholangiocarcinoma following curative resection. Oncol Lett 17: 165-174, 2019.
APA
Wu, Y., Ren, F., Chai, Y., Xue, Z., Shen, C., Zhang, X. ... Hu, L. (2019). Prognostic value of inflammation‑based indexes for intrahepatic cholangiocarcinoma following curative resection. Oncology Letters, 17, 165-174. https://doi.org/10.3892/ol.2018.9618
MLA
Wu, Y., Ren, F., Chai, Y., Xue, Z., Shen, C., Zhang, X., Lv, Y., Hu, L."Prognostic value of inflammation‑based indexes for intrahepatic cholangiocarcinoma following curative resection". Oncology Letters 17.1 (2019): 165-174.
Chicago
Wu, Y., Ren, F., Chai, Y., Xue, Z., Shen, C., Zhang, X., Lv, Y., Hu, L."Prognostic value of inflammation‑based indexes for intrahepatic cholangiocarcinoma following curative resection". Oncology Letters 17, no. 1 (2019): 165-174. https://doi.org/10.3892/ol.2018.9618
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