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Interleukin‑17 promotes the development of cisplatin resistance in colorectal cancer

  • Authors:
    • Guolong Sui
    • Yingna Qiu
    • Haijuan Yu
    • Qingbin Kong
    • Baowen Zhen
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Weihai Central Hospital, Weihai, Shandong 26440, P.R. China, Department of Anesthesia, Weihai Central Hospital, Weihai, Shandong 26440, P.R. China, Department of Nursing, Naiman County People's Hospital, Tongliao, Inner Mongolia 028300, P.R. China, Department of Surgery, Naiman County People's Hospital, Tongliao, Inner Mongolia 028300, P.R. China
    Copyright: © Sui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 944-950
    |
    Published online on: October 31, 2018
       https://doi.org/10.3892/ol.2018.9645
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Abstract

Cisplatin (DDP)‑based anticancer therapy is an important chemotherapeutic strategy for the treatment of colorectal cancer. However, its beneficial effect is largely compromised by adverse reactions, and more importantly, by the development of drug resistance. Therefore, it is crucial to determine the potential mechanism underlying the development of DDP resistance in colorectal cancer. Interleukin‑17 (IL‑17) is a proinflammatory cytokine that has been found to serve an important role in the host defense during cancer development. It has been suggested that IL‑17 is key to promoting the development of resistance to DDP in several major types of cancer. However, the role of IL‑17 in DDP resistance in colorectal cancer has not been extensively investigated. In the present study, it was observed that IL‑17 was significantly upregulated in colorectal tumor samples, compared with the adjacent tissues. Furthermore, IL‑17 was found to promote the viability of HCT116 colorectal cells treated with DDP, whilst blocking IL‑17 signaling leading to HCT116 cell apoptosis. IL‑17 was also shown to regulate the expression of several apoptosis‑related proteins, including phosphorylated‑protein kinase B (p‑Akt), apoptosis regulator BAX (Bax), apoptosis regulator Bcl‑2 (Bcl‑2) and serine/threonine‑protein kinase mTOR (mTOR). These findings indicated that IL‑17 facilitates the development of DDP resistance in colorectal cancer by inhibiting cancer cell apoptosis through targeting p‑Akt, Bax, Bcl‑2 and mTOR. Overall, the findings of the present study suggest that a combination of DDP and an IL‑17 inhibitor may prove to be a highly efficient strategy for colorectal cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Sui G, Qiu Y, Yu H, Kong Q and Zhen B: Interleukin‑17 promotes the development of cisplatin resistance in colorectal cancer. Oncol Lett 17: 944-950, 2019.
APA
Sui, G., Qiu, Y., Yu, H., Kong, Q., & Zhen, B. (2019). Interleukin‑17 promotes the development of cisplatin resistance in colorectal cancer. Oncology Letters, 17, 944-950. https://doi.org/10.3892/ol.2018.9645
MLA
Sui, G., Qiu, Y., Yu, H., Kong, Q., Zhen, B."Interleukin‑17 promotes the development of cisplatin resistance in colorectal cancer". Oncology Letters 17.1 (2019): 944-950.
Chicago
Sui, G., Qiu, Y., Yu, H., Kong, Q., Zhen, B."Interleukin‑17 promotes the development of cisplatin resistance in colorectal cancer". Oncology Letters 17, no. 1 (2019): 944-950. https://doi.org/10.3892/ol.2018.9645
Copy and paste a formatted citation
x
Spandidos Publications style
Sui G, Qiu Y, Yu H, Kong Q and Zhen B: Interleukin‑17 promotes the development of cisplatin resistance in colorectal cancer. Oncol Lett 17: 944-950, 2019.
APA
Sui, G., Qiu, Y., Yu, H., Kong, Q., & Zhen, B. (2019). Interleukin‑17 promotes the development of cisplatin resistance in colorectal cancer. Oncology Letters, 17, 944-950. https://doi.org/10.3892/ol.2018.9645
MLA
Sui, G., Qiu, Y., Yu, H., Kong, Q., Zhen, B."Interleukin‑17 promotes the development of cisplatin resistance in colorectal cancer". Oncology Letters 17.1 (2019): 944-950.
Chicago
Sui, G., Qiu, Y., Yu, H., Kong, Q., Zhen, B."Interleukin‑17 promotes the development of cisplatin resistance in colorectal cancer". Oncology Letters 17, no. 1 (2019): 944-950. https://doi.org/10.3892/ol.2018.9645
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