Open Access

miR-29 promotes osteosarcoma cell proliferation and migration by targeting PTEN

  • Authors:
    • Qiuliang Liu
    • Peishuo Geng
    • Longyan Shi
    • Qi Wang
    • Pengliang Wang
  • View Affiliations

  • Published online on: October 31, 2018     https://doi.org/10.3892/ol.2018.9646
  • Pages: 883-890
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Abstract

Osteosarcoma (OS) is an aggressive malignant neoplasm that arises from primitively transformed cells of mesenchymal origin, and that exhibits osteoblastic differentiation and produces malignant osteoid. MicroRNAs (miRNAs) have been widely reported to have important regulatory roles in various human tumors, including OS. However, the potential mechanism of miR-29 in OS remains largely unknown. miR-29 was highly expressed in OS and overexpression of miR-29 promoted OS cell proliferation, as well as proliferating cell nuclear antigen (PCNA) expression and migration, whereas lower expression of miR-29 inhibited OS cell proliferation, PCNA expression and migration. In the present study, a dual-luciferase reporter system supporting phosphatase and tensin homolog (PTEN) was a target of miR-29 and its expression was inhibited by miR-29 mimic, but increased by miR-29 inhibitor. Overexpression of PTEN inhibited OS cell proliferation and migration and it could attenuate miR-29 promotion effect on OS progression. Overall, the results revealed that miR-29, as a tumor promoter, is involved in OS progression and metastasis by targeting PTEN, indicating that the miR-29/PTEN pathway is a potential therapeutic target for the treatment of OS.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liu Q, Geng P, Shi L, Wang Q and Wang P: miR-29 promotes osteosarcoma cell proliferation and migration by targeting PTEN. Oncol Lett 17: 883-890, 2019
APA
Liu, Q., Geng, P., Shi, L., Wang, Q., & Wang, P. (2019). miR-29 promotes osteosarcoma cell proliferation and migration by targeting PTEN. Oncology Letters, 17, 883-890. https://doi.org/10.3892/ol.2018.9646
MLA
Liu, Q., Geng, P., Shi, L., Wang, Q., Wang, P."miR-29 promotes osteosarcoma cell proliferation and migration by targeting PTEN". Oncology Letters 17.1 (2019): 883-890.
Chicago
Liu, Q., Geng, P., Shi, L., Wang, Q., Wang, P."miR-29 promotes osteosarcoma cell proliferation and migration by targeting PTEN". Oncology Letters 17, no. 1 (2019): 883-890. https://doi.org/10.3892/ol.2018.9646