Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2019 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2019 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Ki‑67 is an independent prognostic marker for the recurrence and relapse of oral squamous cell carcinoma

  • Authors:
    • Yue Jing
    • Qian Zhou
    • Huidong Zhu
    • Ye Zhang
    • Yuxian Song
    • Xiaoxin Zhang
    • Xiaofeng Huang
    • Yan Yang
    • Yanhong Ni
    • Qingang Hu
  • View Affiliations / Copyright

    Affiliations: Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210008, P.R. China, Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210008, P.R. China
    Copyright: © Jing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 974-980
    |
    Published online on: October 31, 2018
       https://doi.org/10.3892/ol.2018.9647
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

As a nuclear and nucleolar protein, proliferation marker protein Ki‑67 (Ki‑67) serves a vital role in tumorigenesis due to its positive correlation with tumor proliferation. High expression of Ki‑67 in the cell cycle from the G1 to M phase makes it a potential biomarker for certain tumors and useful for selecting medical treatment. However, the diagnostic value of Ki‑67 in oral squamous cell carcinoma (OSCC) has not been fully evaluated. In the present study, the objective was the elucidation of the prognostic value of Ki‑67 in a large number of OSCC patients. Ki‑67 expression was detected by immunohistochemical staining methods in 298 OSCC specimens and 98 tumor‑free oral mucosa specimens (62 dysplasia mucosa and 36 normal mucosa), acquired from Nanjing Stomatological Hospital, Medical School of Nanjing University (Nanjing, China). Expression of Ki‑67 in normal tissues, dysplasia tissues and OSCC tissues was compared. Associations between Ki‑67 expression and clinicopathological parameters were analyzed by χ2 test. Kaplan‑Meier survival curves and Cox progression analysis were used to assess the diagnostic value of Ki‑67 for OSCC. The results showed that Ki‑67 expression was higher in OSCC tissues than in tumor‑free tissues and that it increased with the progression of dysplasia in oral mucosa tissues. In addition, patients with high Ki‑67 expression had a worse clinical outcome, including poor tumor differentiation (P=0.001), increased positive lymph node metastasis (P=0.006) and increased worst pattern of invasion type (P<0.0001). Kaplan‑Meier survival analysis demonstrated that higher Ki‑67 expression was associated with poorer overall survival (OS) (P=0.035), recurrence‑free survival (RFS) (P=0.017), metastasis‑free survival (MFS) (P=0.032) and disease‑free survival (DFS) (P=0.018) times. Additional multivariate analysis demonstrated that Ki‑67 expression was negatively associated with OS, DFS, RFS and MFS. In conclusion, Ki‑67 overexpression is associated with the progression of OSCC and serves as an independent prognostic factor for OSCC patients.
View Figures

Figure 1

Figure 2

View References

1 

Bagan J, Sarrion G and Jimenez Y: Oral cancer: Cral precancer and cancer and preventive measures. Clinical Oral investigations. 5:207–213. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Reichart PA: Identification of risk groups for oral precancer and cancer and preventive measures. Clin Oral Investig. 5:207–213. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Perez-Sayans M, Somoza-Martin JM, Barros-Angueira F, Reboiras-Lopez MD, Gandara Rey JM and Garcia-Garcia A: Genetic and molecular alterations associated with oral squamous cell cancer (Review). Oncol Rep. 22:1277–1282. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Sasahira T, Kirita T and Kuniyasu H: Update of molecular pathobiology in oral cancer: A review. Int J Clin Oncol. 19:431–436. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Ost P, Bossi A, Decaestecker K, De Meerleer G, Giannarini G, Karnes RJ, Roach M III and Briganti A: Metastasis-directed therapy of regional and distant recurrences after curative treatment of prostate cancer: A systematic review of the literature. Eur Urol. 67:852–863. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Sannam Khan R, Khurshid Z, Akhbar S and Faraz Moin S: Advances of Salivary Proteomics in Oral Squamous Cell Carcinoma (OSCC) Detection: An Update. Proteomes. 4(piii): E412016. View Article : Google Scholar : PubMed/NCBI

7 

Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U and Stein H: Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol. 133:1710–1715. 1984.PubMed/NCBI

8 

Li LT, Jiang G, Chen Q and Zheng JN: Ki67 is a promising molecular target in the diagnosis of cancer (review). Mol Med Rep. 11:1566–1572. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Antonarakis ES, Keizman D, Zhang Z, Gurel B, Lotan TL, Hicks JL, Fedor HL, Carducci MA, De Marzo AM and Eisenberger MA: An immunohistochemical signature comprising PTEN, MYC, and Ki67 predicts progression in prostate cancer patients receiving adjuvant docetaxel after prostatectomy. Cancer. 118:6063–6071. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Kim J, Han W, Jung SY, Park YH, Moon HG, Ahn SK, Lee JW, Kim MK, Kim JJ, Lee ES, et al: The Value of Ki67 in Very Young Women with hormone receptor-positive breast cancer: Retrospective Analysis of 9,321 Korean Women. Ann Surg Oncol. 22:3481–3488. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Melling N, Kowitz CM, Simon R, Bokemeyer C, Terracciano L, Sauter G, Izbicki JR and Marx AH: High Ki67 expression is an independent good prognostic marker in colorectal cancer. J Clin Pathol. 69:209–214. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Pascale M, Aversa C, Barbazza R, Marongiu B, Siracusano S, Stoffel F, Sulfaro S, Roggero E, Bonin S and Stanta G: The proliferation marker Ki67, but not neuroendocrine expression, is an independent factor in the prediction of prognosis of primary prostate cancer patients. Radiol Oncol. 50:313–320. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Zhou Y, Li Y, Zheng J, Liu K and Zhang H: Detecting of gastric cancer by Bcl-2 and Ki67. Int J Clin Exp Pathol. 8:7287–7290. 2015.PubMed/NCBI

14 

Lindsay CR, Le Moulec S, Billiot F, Loriot Y, Ngo-Camus M, Vielh P, Fizazi K, Massard C and Farace F: Vimentin and Ki67 expression in circulating tumour cells derived from castrate-resistant prostate cancer. BMC Cancer. 16:1682016. View Article : Google Scholar : PubMed/NCBI

15 

Panzuto F, Cicchese N, Partelli S, Rinzivillo M, Capurso G, Merola E, Manzoni M, Pucci E, Iannicelli E, Pilozzi E, et al: Impact of Ki67 re-assessment at time of disease progression in patients with pancreatic neuroendocrine neoplasms. PLoS One. 12:e01794452017. View Article : Google Scholar : PubMed/NCBI

16 

Liu M, Lawson G, Delos M, Jamart J, Ide C, Coche E, Weynand B, Desuter G, Hamoir M, Remacle M and Marbaix E: Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis: Comparison with clinical and radiologic examinations. Head Neck. 25:280–288. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Keohane SG, Proby CM, Newlands C, Motley RJ, Nasr I, Mohd Mustapa MF and Slater DN: The new 8th edition of TNM staging and its implications for skin cancer: a review by the British Association of Dermatologists and the Royal College of Pathologists, United Kingdom. Br J Dermatol. 2018.(Epub ahead of print). View Article : Google Scholar

18 

Heerema MG, Melchers LJ, Roodenburg JL, Schuuring E, de Bock GH and van der Vegt B: Reproducibility and prognostic value of pattern of invasion scoring in low-stage oral squamous cell carcinoma. Histopathology. 68:388–397. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Kuperman DI, Auethavekiat V, Adkins DR, Nussenbaum B, Collins S, Boonchalermvichian C, Trinkaus K, Chen L and Morgensztern D: Squamous cell cancer of the head and neck with distant metastasis at presentation. Head Neck. 33:714–718. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Towle R, Truong D and Garnis C: Epigenetic mediated silencing of EYA4 contributes to tumorigenesis in oral dysplastic cells. Genes Chromosomes Cancer. 55:568–576. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Noguti J, De Moura CF, De Jesus GP, Da Silva VH, Hossaka TA, Oshima CT and Ribeiro DA: Metastasis from oral cancer: An overview. Cancer Genomics Proteomics. 9:329–335. 2012.PubMed/NCBI

23 

Yurakh AO, Ramos D, Calabuig-Farinas S, López-Guerrero JA, Rubio J, Solsona E, Romanenko AM, Vozianov AF, Pellin A and Llombart-Bosch A: Molecular and immunohistochemical analysis of the prognostic value of cell-cycle regulators in urothelial neoplasms of the bladder. Eur Urol. 50:506–515. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Brown DC and Gatter KC: Ki67 protein: The immaculate deception? Histopathology. 40:2–11. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Wu TT, Chen JH, Lee YH and Huang JK: The role of bcl-2, p53, and ki-67 index in predicting tumor recurrence for low grade superficial transitional cell bladder carcinoma. J Urol. 163:758–760. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Li H, Han X, Liu Y, Liu G and Dong G: Ki67 as a predictor of poor prognosis in patients with triple-negative breast cancer. Oncol Lett. 9:149–152. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Li W, Zhang G, Wang HL and Wang L: Analysis of expression of cyclin E, p27kip1 and Ki67 protein in colorectal cancer tissues and its value for diagnosis, treatment and prognosis of disease. Eur Rev Med Pharmacol Sci. 20:4874–4879. 2016.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jing Y, Zhou Q, Zhu H, Zhang Y, Song Y, Zhang X, Huang X, Yang Y, Ni Y, Hu Q, Hu Q, et al: Ki‑67 is an independent prognostic marker for the recurrence and relapse of oral squamous cell carcinoma. Oncol Lett 17: 974-980, 2019.
APA
Jing, Y., Zhou, Q., Zhu, H., Zhang, Y., Song, Y., Zhang, X. ... Hu, Q. (2019). Ki‑67 is an independent prognostic marker for the recurrence and relapse of oral squamous cell carcinoma. Oncology Letters, 17, 974-980. https://doi.org/10.3892/ol.2018.9647
MLA
Jing, Y., Zhou, Q., Zhu, H., Zhang, Y., Song, Y., Zhang, X., Huang, X., Yang, Y., Ni, Y., Hu, Q."Ki‑67 is an independent prognostic marker for the recurrence and relapse of oral squamous cell carcinoma". Oncology Letters 17.1 (2019): 974-980.
Chicago
Jing, Y., Zhou, Q., Zhu, H., Zhang, Y., Song, Y., Zhang, X., Huang, X., Yang, Y., Ni, Y., Hu, Q."Ki‑67 is an independent prognostic marker for the recurrence and relapse of oral squamous cell carcinoma". Oncology Letters 17, no. 1 (2019): 974-980. https://doi.org/10.3892/ol.2018.9647
Copy and paste a formatted citation
x
Spandidos Publications style
Jing Y, Zhou Q, Zhu H, Zhang Y, Song Y, Zhang X, Huang X, Yang Y, Ni Y, Hu Q, Hu Q, et al: Ki‑67 is an independent prognostic marker for the recurrence and relapse of oral squamous cell carcinoma. Oncol Lett 17: 974-980, 2019.
APA
Jing, Y., Zhou, Q., Zhu, H., Zhang, Y., Song, Y., Zhang, X. ... Hu, Q. (2019). Ki‑67 is an independent prognostic marker for the recurrence and relapse of oral squamous cell carcinoma. Oncology Letters, 17, 974-980. https://doi.org/10.3892/ol.2018.9647
MLA
Jing, Y., Zhou, Q., Zhu, H., Zhang, Y., Song, Y., Zhang, X., Huang, X., Yang, Y., Ni, Y., Hu, Q."Ki‑67 is an independent prognostic marker for the recurrence and relapse of oral squamous cell carcinoma". Oncology Letters 17.1 (2019): 974-980.
Chicago
Jing, Y., Zhou, Q., Zhu, H., Zhang, Y., Song, Y., Zhang, X., Huang, X., Yang, Y., Ni, Y., Hu, Q."Ki‑67 is an independent prognostic marker for the recurrence and relapse of oral squamous cell carcinoma". Oncology Letters 17, no. 1 (2019): 974-980. https://doi.org/10.3892/ol.2018.9647
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team