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MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma

  • Authors:
    • Junsheng Lian
    • Yujie Li
    • Min Yu
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology Head and Neck Surgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, P.R. China
    Copyright: © Lian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1172-1176
    |
    Published online on: November 1, 2018
       https://doi.org/10.3892/ol.2018.9650
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Abstract

This study investigated whether microRNA‑183 and microRNA‑141 in nasopharyngeal carcinoma (NPC) lesions are potential risk factors for poor prognosis. A total of 317 NPC patients admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2010 to March 2015 were included. Reverse transcription‑quantitative PCR (RT‑qPCR) was used to detect the expression of microRNA‑183 and microRNA‑141 in lesions and adjacent tissues, and the relationship between the microRNA‑183 and microRNA‑141 expression levels and prognosis was analyzed. The expression levels of microRNA‑183 and microRNA‑141 in lesions were significantly higher than those in adjacent tissues (p<0.05). Patients with distant metastasis had significantly higher expression levels of microRNA‑183 and microRNA‑141 than patients without distant metastasis (p<0.01). Patients with disease‑free survival (DFS) <3 years showed significantly higher expression levels of microRNA‑183 and microRNA‑141 than those with DFS ≥3 years (p<0.01). NPC patients with high expression levels of microRNA‑183 and microRNA‑141 showed poor prognosis. MicroRNA‑183 and microRNA‑141 may play an important role in the distant metastasis of NPC, and have a great impact on prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Lian J, Li Y and Yu M: MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma. Oncol Lett 17: 1172-1176, 2019.
APA
Lian, J., Li, Y., & Yu, M. (2019). MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma. Oncology Letters, 17, 1172-1176. https://doi.org/10.3892/ol.2018.9650
MLA
Lian, J., Li, Y., Yu, M."MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma". Oncology Letters 17.1 (2019): 1172-1176.
Chicago
Lian, J., Li, Y., Yu, M."MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma". Oncology Letters 17, no. 1 (2019): 1172-1176. https://doi.org/10.3892/ol.2018.9650
Copy and paste a formatted citation
x
Spandidos Publications style
Lian J, Li Y and Yu M: MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma. Oncol Lett 17: 1172-1176, 2019.
APA
Lian, J., Li, Y., & Yu, M. (2019). MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma. Oncology Letters, 17, 1172-1176. https://doi.org/10.3892/ol.2018.9650
MLA
Lian, J., Li, Y., Yu, M."MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma". Oncology Letters 17.1 (2019): 1172-1176.
Chicago
Lian, J., Li, Y., Yu, M."MicroRNA‑183 and microRNA‑141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma". Oncology Letters 17, no. 1 (2019): 1172-1176. https://doi.org/10.3892/ol.2018.9650
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