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Article

Comprehensive bioinformatics analysis of lncRNAs in gastric cancer

  • Authors:
    • Dongdong Qi
    • Qiang Wang
    • Meiqing Wu
    • Xiong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Hulunbuir Mental Health Center, Hulunbuir, Inner Mongolia 022150, P.R. China, Department of General Surgery, Inner Mongolia Forestry General Hospital, Hulunbuir, Inner Mongolia 022150, P.R. China, Dermatological Department, Inner Mongolia Forestry General Hospital, Hulunbuir, Inner Mongolia 022150, P.R. China, Hulunbuir Mental Health Center, Hulunbuir, Inner Mongolia 022150, P.R. China
  • Pages: 1279-1291
    |
    Published online on: November 15, 2018
       https://doi.org/10.3892/ol.2018.9707
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Abstract

Long non‑coding RNAs (lncRNAs) have been generally considered to serve important roles in various types of cancer, including gastric cancer. However, a comprehensive understanding of lncRNAs in gastric cancer requires further study. The present study performed an in‑depth study revealed 50 differently expressed lncRNAs. The changed cellular pathways and biological process in gastric cancer were determined. To further confirm the functions of the differently expressed lncRNAs, co‑expression networks were constructed between the lncRNAs and mRNA; this lead to the identification of 6 modules, which participated in various cellular pathways. In addition, 2 lncRNAs were identified which were associated with clinical outcome. The biological analysis and experimental evidence suggested that LINC00982 inhibited, while LL22NC03‑N14H11.1 promoted the proliferation of gastric cancer cells. These lncRNAs may be considered as potential prognostic factor in gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Qi D, Wang Q, Wu M and Zhang X: Comprehensive bioinformatics analysis of lncRNAs in gastric cancer. Oncol Lett 17: 1279-1291, 2019.
APA
Qi, D., Wang, Q., Wu, M., & Zhang, X. (2019). Comprehensive bioinformatics analysis of lncRNAs in gastric cancer. Oncology Letters, 17, 1279-1291. https://doi.org/10.3892/ol.2018.9707
MLA
Qi, D., Wang, Q., Wu, M., Zhang, X."Comprehensive bioinformatics analysis of lncRNAs in gastric cancer". Oncology Letters 17.1 (2019): 1279-1291.
Chicago
Qi, D., Wang, Q., Wu, M., Zhang, X."Comprehensive bioinformatics analysis of lncRNAs in gastric cancer". Oncology Letters 17, no. 1 (2019): 1279-1291. https://doi.org/10.3892/ol.2018.9707
Copy and paste a formatted citation
x
Spandidos Publications style
Qi D, Wang Q, Wu M and Zhang X: Comprehensive bioinformatics analysis of lncRNAs in gastric cancer. Oncol Lett 17: 1279-1291, 2019.
APA
Qi, D., Wang, Q., Wu, M., & Zhang, X. (2019). Comprehensive bioinformatics analysis of lncRNAs in gastric cancer. Oncology Letters, 17, 1279-1291. https://doi.org/10.3892/ol.2018.9707
MLA
Qi, D., Wang, Q., Wu, M., Zhang, X."Comprehensive bioinformatics analysis of lncRNAs in gastric cancer". Oncology Letters 17.1 (2019): 1279-1291.
Chicago
Qi, D., Wang, Q., Wu, M., Zhang, X."Comprehensive bioinformatics analysis of lncRNAs in gastric cancer". Oncology Letters 17, no. 1 (2019): 1279-1291. https://doi.org/10.3892/ol.2018.9707
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