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Article Open Access

miR‑7‑5p inhibits cell migration and invasion in glioblastoma through targeting SATB1

  • Authors:
    • Chang‑You Yin
    • Wei Kong
    • Jing Jiang
    • Hao Xu
    • Wei Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China, Department of Emergency, Yantaishan Hospital, Yantai, Shandong 264001, P.R. China
  • Pages: 1819-1825
    |
    Published online on: November 28, 2018
       https://doi.org/10.3892/ol.2018.9777
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Abstract

MicroRNAs (miRNAs/miRs) have been revealed to influence the development and progression of glioblastoma. Although a number of miRNAs are abnormally expressed in glioblastoma it is not clear whether they are a factor associated with glioblastoma pathogenesis. In the present study, miR‑7‑5p was identified as being aberrantly downregulated in glioblastoma tissues and cell lines. miR‑7‑5p overexpression significantly decreased the migratory and invasive capacity of the cells, while miR‑7‑5p silencing had the opposite effect. In addition, a luciferase assay confirmed that special AT rich sequence binding protein 1 (SATB1) was a direct target gene of miR‑7‑5p in glioblastoma. The overexpression of SATB1 in glioblastoma was revealed to promote cell migration and invasion. In addition, SATB1 overexpression may weaken the inhibitory effect of miR‑7‑5p on cell migration and invasion. miR‑7‑5p overexpression reversed the effects of SATB1 on cell migration and invasion in glioblastoma cells. In conclusion, miR‑7‑5p may be a useful therapeutic target for the diagnosis and treatment of patients with glioblastoma.
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Copy and paste a formatted citation
Spandidos Publications style
Yin CY, Kong W, Jiang J, Xu H and Zhao W: miR‑7‑5p inhibits cell migration and invasion in glioblastoma through targeting SATB1. Oncol Lett 17: 1819-1825, 2019.
APA
Yin, C., Kong, W., Jiang, J., Xu, H., & Zhao, W. (2019). miR‑7‑5p inhibits cell migration and invasion in glioblastoma through targeting SATB1. Oncology Letters, 17, 1819-1825. https://doi.org/10.3892/ol.2018.9777
MLA
Yin, C., Kong, W., Jiang, J., Xu, H., Zhao, W."miR‑7‑5p inhibits cell migration and invasion in glioblastoma through targeting SATB1". Oncology Letters 17.2 (2019): 1819-1825.
Chicago
Yin, C., Kong, W., Jiang, J., Xu, H., Zhao, W."miR‑7‑5p inhibits cell migration and invasion in glioblastoma through targeting SATB1". Oncology Letters 17, no. 2 (2019): 1819-1825. https://doi.org/10.3892/ol.2018.9777
Copy and paste a formatted citation
x
Spandidos Publications style
Yin CY, Kong W, Jiang J, Xu H and Zhao W: miR‑7‑5p inhibits cell migration and invasion in glioblastoma through targeting SATB1. Oncol Lett 17: 1819-1825, 2019.
APA
Yin, C., Kong, W., Jiang, J., Xu, H., & Zhao, W. (2019). miR‑7‑5p inhibits cell migration and invasion in glioblastoma through targeting SATB1. Oncology Letters, 17, 1819-1825. https://doi.org/10.3892/ol.2018.9777
MLA
Yin, C., Kong, W., Jiang, J., Xu, H., Zhao, W."miR‑7‑5p inhibits cell migration and invasion in glioblastoma through targeting SATB1". Oncology Letters 17.2 (2019): 1819-1825.
Chicago
Yin, C., Kong, W., Jiang, J., Xu, H., Zhao, W."miR‑7‑5p inhibits cell migration and invasion in glioblastoma through targeting SATB1". Oncology Letters 17, no. 2 (2019): 1819-1825. https://doi.org/10.3892/ol.2018.9777
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