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Efficacy and safety of consolidation chemotherapy during the resting period in patients with local advanced rectal cancer

  • Authors:
    • Huan‑Qing Liang
    • Zhong‑Yi Dong
    • Zhi‑Jie Liu
    • Jiao Luo
    • Qin Zeng
    • Ping‑Yan Liao
    • De‑Hua Wu
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Radiation Oncology, Cancer Institute of Guangxi Zhuang Autonomous Region, The Affiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Pages: 1655-1663
    |
    Published online on: December 6, 2018
       https://doi.org/10.3892/ol.2018.9804
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Abstract

It remains controversial as to whether a long interval between neoadjuvant chemoradiotherapy (NCRT) and surgery may provide clinical benefits for patients with local advanced rectal cancer (LARC). The addition of consolidation chemotherapy during the resting period was recently considered as a treatment option. The present study aimed to verify the efficacy and safety of consolidation chemotherapy during the resting period in patients with LARC. A total of 156 patients with local advanced stage T3‑4N0‑2 rectal cancer were enrolled between January 2010 and July 2016. Patients were divided into two groups, those who received consolidation chemotherapy prior to surgery (n=76) and the control group who did not (n=80). Multivariate logistic regression and the Kaplan‑Meier method were used to explore the predictors of pathological complete response (pCR) and survival. The demographic and tumor characteristics were comparable between the two groups. The consolidation group yielded significantly higher pCR and near pCR rates compared with the control group (P=0.015). Patients in the consolidation group who also underwent standard adjuvant chemotherapy displayed improved 3‑year disease‑free survival (DFS) compared with the control group (P=0.036). Notably, the addition of consolidation chemotherapy between NCRT and surgery did not significantly increase the incidence of surgical complications and grade 3 or 4 toxicities when compared with the control group. Consolidation chemotherapy was associated with increased pCR/near pCR rates and improved 3‑year DFS, and displayed a manageable safety profile. The present study provided primary evidence for the efficacy and safety of consolidation chemotherapy in LARC. Further prospective studies are warranted in the future to verify these results.
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Copy and paste a formatted citation
Spandidos Publications style
Liang HQ, Dong ZY, Liu ZJ, Luo J, Zeng Q, Liao PY and Wu DH: Efficacy and safety of consolidation chemotherapy during the resting period in patients with local advanced rectal cancer. Oncol Lett 17: 1655-1663, 2019.
APA
Liang, H., Dong, Z., Liu, Z., Luo, J., Zeng, Q., Liao, P., & Wu, D. (2019). Efficacy and safety of consolidation chemotherapy during the resting period in patients with local advanced rectal cancer. Oncology Letters, 17, 1655-1663. https://doi.org/10.3892/ol.2018.9804
MLA
Liang, H., Dong, Z., Liu, Z., Luo, J., Zeng, Q., Liao, P., Wu, D."Efficacy and safety of consolidation chemotherapy during the resting period in patients with local advanced rectal cancer". Oncology Letters 17.2 (2019): 1655-1663.
Chicago
Liang, H., Dong, Z., Liu, Z., Luo, J., Zeng, Q., Liao, P., Wu, D."Efficacy and safety of consolidation chemotherapy during the resting period in patients with local advanced rectal cancer". Oncology Letters 17, no. 2 (2019): 1655-1663. https://doi.org/10.3892/ol.2018.9804
Copy and paste a formatted citation
x
Spandidos Publications style
Liang HQ, Dong ZY, Liu ZJ, Luo J, Zeng Q, Liao PY and Wu DH: Efficacy and safety of consolidation chemotherapy during the resting period in patients with local advanced rectal cancer. Oncol Lett 17: 1655-1663, 2019.
APA
Liang, H., Dong, Z., Liu, Z., Luo, J., Zeng, Q., Liao, P., & Wu, D. (2019). Efficacy and safety of consolidation chemotherapy during the resting period in patients with local advanced rectal cancer. Oncology Letters, 17, 1655-1663. https://doi.org/10.3892/ol.2018.9804
MLA
Liang, H., Dong, Z., Liu, Z., Luo, J., Zeng, Q., Liao, P., Wu, D."Efficacy and safety of consolidation chemotherapy during the resting period in patients with local advanced rectal cancer". Oncology Letters 17.2 (2019): 1655-1663.
Chicago
Liang, H., Dong, Z., Liu, Z., Luo, J., Zeng, Q., Liao, P., Wu, D."Efficacy and safety of consolidation chemotherapy during the resting period in patients with local advanced rectal cancer". Oncology Letters 17, no. 2 (2019): 1655-1663. https://doi.org/10.3892/ol.2018.9804
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