Open Access

Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma

  • Authors:
    • Dan‑Dan Zhao
    • Jun Yuan
    • Qi Cheng
    • Ya‑Ling Qi
    • Ke Lu
    • Shan‑Shan Lai
    • Qian Sun
    • Yue Zhao
    • Lei Fang
    • Mei‑Ling Jin
    • De‑Cai Yu
    • Yu‑Dong Qiu
    • Chao‑Jun Li
    • Jun Chen
    • Bin Xue
  • View Affiliations

  • Published online on: December 7, 2018     https://doi.org/10.3892/ol.2018.9808
  • Pages: 1523-1530
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Research on mevalonate kinase deficiency has revealed that it may lead to the development of renal angiomyolipomas (RAMLs). Thus, it was suspected that geranylgeranyl pyrophosphate synthase (GGPPS), a key enzyme in the mevalonate pathway, may be involved in the development of RAMLs. In the present study, the expression of GGPPS in RAMLs and renal epithelioid angiomyolipomas (REAs) was assessed, and paraffin embedded specimens from 60 patients, including 9 cases with REA and 51 cases with RAML, were examined. Immunoreactivity was evaluated semi‑quantitatively according to the intensity of staining and the percentage of positively stained cells. The results indicated that GGPPS was predominantly present in the cytoplasm, and REA tissues exhibited higher expression of GGPPS in the cytoplasm compared with RAML tissues. It was also identified that GGPPS was upregulated in TSC2‑null cells, and inhibition of GGPPS could induce apoptosis of TSC2‑null cells by autophagy. In conclusion, the increased expression of GGPPS in RAMLs and REAs indicated that mevalonate pathways may be involved in disease progression. GGPPS may serve as a potential therapeutic target and the current results may provide a novel therapeutic strategy for RAML and lymphangioleiomyomatosis.
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao DD, Yuan J, Cheng Q, Qi YL, Lu K, Lai SS, Sun Q, Zhao Y, Fang L, Jin ML, Jin ML, et al: Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma. Oncol Lett 17: 1523-1530, 2019
APA
Zhao, D., Yuan, J., Cheng, Q., Qi, Y., Lu, K., Lai, S. ... Xue, B. (2019). Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma. Oncology Letters, 17, 1523-1530. https://doi.org/10.3892/ol.2018.9808
MLA
Zhao, D., Yuan, J., Cheng, Q., Qi, Y., Lu, K., Lai, S., Sun, Q., Zhao, Y., Fang, L., Jin, M., Yu, D., Qiu, Y., Li, C., Chen, J., Xue, B."Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma". Oncology Letters 17.2 (2019): 1523-1530.
Chicago
Zhao, D., Yuan, J., Cheng, Q., Qi, Y., Lu, K., Lai, S., Sun, Q., Zhao, Y., Fang, L., Jin, M., Yu, D., Qiu, Y., Li, C., Chen, J., Xue, B."Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma". Oncology Letters 17, no. 2 (2019): 1523-1530. https://doi.org/10.3892/ol.2018.9808