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Article Open Access

Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma

  • Authors:
    • Dan‑Dan Zhao
    • Jun Yuan
    • Qi Cheng
    • Ya‑Ling Qi
    • Ke Lu
    • Shan‑Shan Lai
    • Qian Sun
    • Yue Zhao
    • Lei Fang
    • Mei‑Ling Jin
    • De‑Cai Yu
    • Yu‑Dong Qiu
    • Chao‑Jun Li
    • Jun Chen
    • Bin Xue
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine and School of Medicine, Nanjing University, Nanjing, Jiangsu 210093, P.R. China, Biochemical and Environmental Engineering School of Xiaozhuang College, Nanjing 211171, P.R. China, Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023, P.R. China, Pulmonary Department, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Liver Disease Collaborative Research Platform of Medical School of Nanjing University, Nanjing, Jiangsu 210093, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1523-1530
    |
    Published online on: December 7, 2018
       https://doi.org/10.3892/ol.2018.9808
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Abstract

Research on mevalonate kinase deficiency has revealed that it may lead to the development of renal angiomyolipomas (RAMLs). Thus, it was suspected that geranylgeranyl pyrophosphate synthase (GGPPS), a key enzyme in the mevalonate pathway, may be involved in the development of RAMLs. In the present study, the expression of GGPPS in RAMLs and renal epithelioid angiomyolipomas (REAs) was assessed, and paraffin embedded specimens from 60 patients, including 9 cases with REA and 51 cases with RAML, were examined. Immunoreactivity was evaluated semi‑quantitatively according to the intensity of staining and the percentage of positively stained cells. The results indicated that GGPPS was predominantly present in the cytoplasm, and REA tissues exhibited higher expression of GGPPS in the cytoplasm compared with RAML tissues. It was also identified that GGPPS was upregulated in TSC2‑null cells, and inhibition of GGPPS could induce apoptosis of TSC2‑null cells by autophagy. In conclusion, the increased expression of GGPPS in RAMLs and REAs indicated that mevalonate pathways may be involved in disease progression. GGPPS may serve as a potential therapeutic target and the current results may provide a novel therapeutic strategy for RAML and lymphangioleiomyomatosis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao DD, Yuan J, Cheng Q, Qi YL, Lu K, Lai SS, Sun Q, Zhao Y, Fang L, Jin ML, Jin ML, et al: Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma. Oncol Lett 17: 1523-1530, 2019.
APA
Zhao, D., Yuan, J., Cheng, Q., Qi, Y., Lu, K., Lai, S. ... Xue, B. (2019). Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma. Oncology Letters, 17, 1523-1530. https://doi.org/10.3892/ol.2018.9808
MLA
Zhao, D., Yuan, J., Cheng, Q., Qi, Y., Lu, K., Lai, S., Sun, Q., Zhao, Y., Fang, L., Jin, M., Yu, D., Qiu, Y., Li, C., Chen, J., Xue, B."Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma". Oncology Letters 17.2 (2019): 1523-1530.
Chicago
Zhao, D., Yuan, J., Cheng, Q., Qi, Y., Lu, K., Lai, S., Sun, Q., Zhao, Y., Fang, L., Jin, M., Yu, D., Qiu, Y., Li, C., Chen, J., Xue, B."Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma". Oncology Letters 17, no. 2 (2019): 1523-1530. https://doi.org/10.3892/ol.2018.9808
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao DD, Yuan J, Cheng Q, Qi YL, Lu K, Lai SS, Sun Q, Zhao Y, Fang L, Jin ML, Jin ML, et al: Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma. Oncol Lett 17: 1523-1530, 2019.
APA
Zhao, D., Yuan, J., Cheng, Q., Qi, Y., Lu, K., Lai, S. ... Xue, B. (2019). Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma. Oncology Letters, 17, 1523-1530. https://doi.org/10.3892/ol.2018.9808
MLA
Zhao, D., Yuan, J., Cheng, Q., Qi, Y., Lu, K., Lai, S., Sun, Q., Zhao, Y., Fang, L., Jin, M., Yu, D., Qiu, Y., Li, C., Chen, J., Xue, B."Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma". Oncology Letters 17.2 (2019): 1523-1530.
Chicago
Zhao, D., Yuan, J., Cheng, Q., Qi, Y., Lu, K., Lai, S., Sun, Q., Zhao, Y., Fang, L., Jin, M., Yu, D., Qiu, Y., Li, C., Chen, J., Xue, B."Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma". Oncology Letters 17, no. 2 (2019): 1523-1530. https://doi.org/10.3892/ol.2018.9808
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