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Article Open Access

Identification of imatinib‑resistant long non‑coding RNAs in gastrointestinal stromal tumors

  • Authors:
    • Jingyi Yan
    • Didi Chen
    • Xiaolei Chen
    • Xuecheng Sun
    • Qiantong Dong
    • Zhou Du
    • Tingting Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and General Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Radiotherapy and Medical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2283-2295
    |
    Published online on: December 11, 2018
       https://doi.org/10.3892/ol.2018.9821
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Abstract

Long non‑coding RNAs (lncRNAs) are an abundant RNA species that belong to the competing endogenous RNA network, which serves a critical role in the development, diagnosis and progression of diseases. Using chip technology, the current study analyzed the expression of lncRNAs in paired normal gastric tissues, primary gastrointestinal stromal tumor (GIST) tissues and GIST tissues resistant to imatinib mesylate. Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses were used to predict potential tumorigenesis and drug resistance mechanisms. The hypoxia‑inducible factor‑1 pathway was identified as a putative mediator of drug resistance. To the best of our knowledge, the current study was the first to investigate the role of lncRNAs in imatinib mesylate‑resistant GISTs and primary GISTs using chip technology. An association was revealed between lncRNA expression and imatinib mesylate resistance. In summary, the current study identified a panel of dysregulated lncRNAs that may serve as potential biomarkers or drug targets for GISTs, particularly secondary imatinib‑resistant GISTs.
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Copy and paste a formatted citation
Spandidos Publications style
Yan J, Chen D, Chen X, Sun X, Dong Q, Du Z and Wang T: Identification of imatinib‑resistant long non‑coding RNAs in gastrointestinal stromal tumors. Oncol Lett 17: 2283-2295, 2019.
APA
Yan, J., Chen, D., Chen, X., Sun, X., Dong, Q., Du, Z., & Wang, T. (2019). Identification of imatinib‑resistant long non‑coding RNAs in gastrointestinal stromal tumors. Oncology Letters, 17, 2283-2295. https://doi.org/10.3892/ol.2018.9821
MLA
Yan, J., Chen, D., Chen, X., Sun, X., Dong, Q., Du, Z., Wang, T."Identification of imatinib‑resistant long non‑coding RNAs in gastrointestinal stromal tumors". Oncology Letters 17.2 (2019): 2283-2295.
Chicago
Yan, J., Chen, D., Chen, X., Sun, X., Dong, Q., Du, Z., Wang, T."Identification of imatinib‑resistant long non‑coding RNAs in gastrointestinal stromal tumors". Oncology Letters 17, no. 2 (2019): 2283-2295. https://doi.org/10.3892/ol.2018.9821
Copy and paste a formatted citation
x
Spandidos Publications style
Yan J, Chen D, Chen X, Sun X, Dong Q, Du Z and Wang T: Identification of imatinib‑resistant long non‑coding RNAs in gastrointestinal stromal tumors. Oncol Lett 17: 2283-2295, 2019.
APA
Yan, J., Chen, D., Chen, X., Sun, X., Dong, Q., Du, Z., & Wang, T. (2019). Identification of imatinib‑resistant long non‑coding RNAs in gastrointestinal stromal tumors. Oncology Letters, 17, 2283-2295. https://doi.org/10.3892/ol.2018.9821
MLA
Yan, J., Chen, D., Chen, X., Sun, X., Dong, Q., Du, Z., Wang, T."Identification of imatinib‑resistant long non‑coding RNAs in gastrointestinal stromal tumors". Oncology Letters 17.2 (2019): 2283-2295.
Chicago
Yan, J., Chen, D., Chen, X., Sun, X., Dong, Q., Du, Z., Wang, T."Identification of imatinib‑resistant long non‑coding RNAs in gastrointestinal stromal tumors". Oncology Letters 17, no. 2 (2019): 2283-2295. https://doi.org/10.3892/ol.2018.9821
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