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MicroRNA‑197‑3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma

  • Authors:
    • Jun‑Sheng Ni
    • Hao Zheng
    • Zhi‑Ping Huang
    • Yong‑Gang Hong
    • Yang‑Liu Ou
    • Yuan‑Ping Tao
    • Meng‑Chao Wang
    • Zhen‑Guang Wang
    • Yuan Yang
    • Wei‑Ping Zhou
  • View Affiliations / Copyright

    Affiliations: Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China, Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China
    Copyright: © Ni et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 2317-2327
    |
    Published online on: December 18, 2018
       https://doi.org/10.3892/ol.2018.9848
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Abstract

MicroRNAs (miRNAs) serve an important regulatory role in carcinogenesis and cancer progression. Aberrant expression of miR‑197‑3p has been reported in various human malignancies. However, the role of miR‑197‑3p in the progression and prognosis of hepatocellular carcinoma (HCC) remains unknown. The present study demonstrated that miR‑197‑3p was downregulated in HCC tissues and that the low level of miR‑197‑3p expression in HCC tumours correlated with aggressive clinicopathological characteristics; thus, miR‑197‑3p may serve as a predictor for poor prognosis in patients with HCC. Additionally, miR‑197‑3p markedly inhibited the metastasis of HCC cells in vitro and in vivo. Bioinformatics analysis further identified zinc finger protein interacted with K protein 1 (ZIK1) as a novel target of miR‑197‑3p in HCC cells. These findings suggest that miR‑197‑3p may regulate the survival of HCC cells, partially through the downregulation of ZIK1. Therefore, the miR‑197‑3p/ZIK1 axis may serve as a novel therapeutic target in patients with HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Ni JS, Zheng H, Huang ZP, Hong YG, Ou YL, Tao YP, Wang MC, Wang ZG, Yang Y, Zhou WP, Zhou WP, et al: MicroRNA‑197‑3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma. Oncol Lett 17: 2317-2327, 2019.
APA
Ni, J., Zheng, H., Huang, Z., Hong, Y., Ou, Y., Tao, Y. ... Zhou, W. (2019). MicroRNA‑197‑3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma. Oncology Letters, 17, 2317-2327. https://doi.org/10.3892/ol.2018.9848
MLA
Ni, J., Zheng, H., Huang, Z., Hong, Y., Ou, Y., Tao, Y., Wang, M., Wang, Z., Yang, Y., Zhou, W."MicroRNA‑197‑3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma". Oncology Letters 17.2 (2019): 2317-2327.
Chicago
Ni, J., Zheng, H., Huang, Z., Hong, Y., Ou, Y., Tao, Y., Wang, M., Wang, Z., Yang, Y., Zhou, W."MicroRNA‑197‑3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma". Oncology Letters 17, no. 2 (2019): 2317-2327. https://doi.org/10.3892/ol.2018.9848
Copy and paste a formatted citation
x
Spandidos Publications style
Ni JS, Zheng H, Huang ZP, Hong YG, Ou YL, Tao YP, Wang MC, Wang ZG, Yang Y, Zhou WP, Zhou WP, et al: MicroRNA‑197‑3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma. Oncol Lett 17: 2317-2327, 2019.
APA
Ni, J., Zheng, H., Huang, Z., Hong, Y., Ou, Y., Tao, Y. ... Zhou, W. (2019). MicroRNA‑197‑3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma. Oncology Letters, 17, 2317-2327. https://doi.org/10.3892/ol.2018.9848
MLA
Ni, J., Zheng, H., Huang, Z., Hong, Y., Ou, Y., Tao, Y., Wang, M., Wang, Z., Yang, Y., Zhou, W."MicroRNA‑197‑3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma". Oncology Letters 17.2 (2019): 2317-2327.
Chicago
Ni, J., Zheng, H., Huang, Z., Hong, Y., Ou, Y., Tao, Y., Wang, M., Wang, Z., Yang, Y., Zhou, W."MicroRNA‑197‑3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma". Oncology Letters 17, no. 2 (2019): 2317-2327. https://doi.org/10.3892/ol.2018.9848
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