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Integrative analysis of gene expression profiles reveals distinct molecular characteristics in oral tongue squamous cell carcinoma

  • Authors:
    • Ranran Wang
    • Xiao Zhou
    • Hui Wang
    • Bo Zhou
    • Shanshan Dong
    • Qi Ding
    • Mingjing Peng
    • Xiaowu Sheng
    • Jianfeng Yao
    • Rongfu Huang
    • Yong Zeng
    • Ying Long
  • View Affiliations / Copyright

    Affiliations: Translational Medicine Center, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China, Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China, Department of Oncoplastic and Reconstructive Surgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China, Reproductive Medicine Center, Quanzhou Maternal and Child Health Hospital, Fujian Medical University, Quanzhou, Fujian 362000, P.R. China, Clinical Laboratory, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian 362000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2377-2387
    |
    Published online on: December 21, 2018
       https://doi.org/10.3892/ol.2018.9866
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Abstract

Oral tongue squamous cell carcinoma (OTSCC) is the most common type of oral cancer. Despite advances in knowledge regarding the genome‑scale gene expression pattern of oral cancer, the molecular portrait of OTSCC biology has remained unclear over the last few decades. Furthermore, studies concerning OTSCC gene‑expression profiles are limited or inconsistent owing to tissue heterogeneity in single‑cohort studies. Consequently, the present study integrated the profile datasets of three cohorts in order to screen for differentially expressed genes (DEGs), and subsequently identified the potential candidate genes and pathways in OTSCC through gene enrichment analysis and protein‑protein interaction (PPI) network construction. Using the selected Gene Expression Omnibus datasets GSE13601, GSE31056 and GSE78060, 206 DEGs (125 upregulated and 81 downregulated) were identified in OTSCC, principally associated with extracellular matrix (ECM) organization and the phosphoinositide 3‑kinase/protein kinase B signaling pathway. Furthermore, 146/206 DEGs were filtered into the PPI network and 20 hub genes were sorted. Further results indicated that the two most significant modules filtered from the PPI network were associated with ECM organization and human papillomavirus infection, which are important factors affecting OTSCC pathology. Overall, a set of OTSCC‑associated DEGs has been identified, including certain key candidate genes that may be of vital importance for diagnosis, therapy and prevention of this disease.
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Wang R, Zhou X, Wang H, Zhou B, Dong S, Ding Q, Peng M, Sheng X, Yao J, Huang R, Huang R, et al: Integrative analysis of gene expression profiles reveals distinct molecular characteristics in oral tongue squamous cell carcinoma. Oncol Lett 17: 2377-2387, 2019.
APA
Wang, R., Zhou, X., Wang, H., Zhou, B., Dong, S., Ding, Q. ... Long, Y. (2019). Integrative analysis of gene expression profiles reveals distinct molecular characteristics in oral tongue squamous cell carcinoma. Oncology Letters, 17, 2377-2387. https://doi.org/10.3892/ol.2018.9866
MLA
Wang, R., Zhou, X., Wang, H., Zhou, B., Dong, S., Ding, Q., Peng, M., Sheng, X., Yao, J., Huang, R., Zeng, Y., Long, Y."Integrative analysis of gene expression profiles reveals distinct molecular characteristics in oral tongue squamous cell carcinoma". Oncology Letters 17.2 (2019): 2377-2387.
Chicago
Wang, R., Zhou, X., Wang, H., Zhou, B., Dong, S., Ding, Q., Peng, M., Sheng, X., Yao, J., Huang, R., Zeng, Y., Long, Y."Integrative analysis of gene expression profiles reveals distinct molecular characteristics in oral tongue squamous cell carcinoma". Oncology Letters 17, no. 2 (2019): 2377-2387. https://doi.org/10.3892/ol.2018.9866
Copy and paste a formatted citation
x
Spandidos Publications style
Wang R, Zhou X, Wang H, Zhou B, Dong S, Ding Q, Peng M, Sheng X, Yao J, Huang R, Huang R, et al: Integrative analysis of gene expression profiles reveals distinct molecular characteristics in oral tongue squamous cell carcinoma. Oncol Lett 17: 2377-2387, 2019.
APA
Wang, R., Zhou, X., Wang, H., Zhou, B., Dong, S., Ding, Q. ... Long, Y. (2019). Integrative analysis of gene expression profiles reveals distinct molecular characteristics in oral tongue squamous cell carcinoma. Oncology Letters, 17, 2377-2387. https://doi.org/10.3892/ol.2018.9866
MLA
Wang, R., Zhou, X., Wang, H., Zhou, B., Dong, S., Ding, Q., Peng, M., Sheng, X., Yao, J., Huang, R., Zeng, Y., Long, Y."Integrative analysis of gene expression profiles reveals distinct molecular characteristics in oral tongue squamous cell carcinoma". Oncology Letters 17.2 (2019): 2377-2387.
Chicago
Wang, R., Zhou, X., Wang, H., Zhou, B., Dong, S., Ding, Q., Peng, M., Sheng, X., Yao, J., Huang, R., Zeng, Y., Long, Y."Integrative analysis of gene expression profiles reveals distinct molecular characteristics in oral tongue squamous cell carcinoma". Oncology Letters 17, no. 2 (2019): 2377-2387. https://doi.org/10.3892/ol.2018.9866
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