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Case Report Open Access

Neoadjuvant chemoradiotherapy followed by liver transplantation is a promising treatment for patients with unresectable hilar cholangiocarcinoma: A case report

  • Authors:
    • Jun Wang
    • Halmurat Obulkasim
    • Xiaoping Zou
    • Baorui Liu
    • Yafu Wu
    • Xingyu Wu
    • Yitao Ding
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China, Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China, Department of Oncology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2069-2074
    |
    Published online on: December 28, 2018
       https://doi.org/10.3892/ol.2018.9878
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Abstract

Hilar cholangiocarcinoma is a highly malignant tumor and is currently treated by surgical resection or liver transplantation; however, these treatments result in poor patient prognosis accompanied with high recurrence and low patient mortality rates. Neoadjuvant therapy with liver transplantation is a novel treatment that exhibits promising clinical application, with a reported 5‑year survival rate of 82%. However, transplantation centers conducting research into this treatment are limited due to its length and complexity. In the current study, the effects of brachytherapy and chemoradiotherapy followed by orthotopic liver transplantation (OLT) were investigated in a patient with unresectable hilar cholangiocarcinoma. Following treatment, the liver function of the patient normalized and physical status significantly improved. Furthermore, tomographic evaluation demonstrated no sign of recurrence 8 months later following continued adjunct chemotherapy. Therefore, neoadjuvant therapy followed by OLT may be an effective novel therapeutic strategy to treat patients with unresectable hilar cholangiocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Obulkasim H, Zou X, Liu B, Wu Y, Wu X and Ding Y: Neoadjuvant chemoradiotherapy followed by liver transplantation is a promising treatment for patients with unresectable hilar cholangiocarcinoma: A case report. Oncol Lett 17: 2069-2074, 2019.
APA
Wang, J., Obulkasim, H., Zou, X., Liu, B., Wu, Y., Wu, X., & Ding, Y. (2019). Neoadjuvant chemoradiotherapy followed by liver transplantation is a promising treatment for patients with unresectable hilar cholangiocarcinoma: A case report. Oncology Letters, 17, 2069-2074. https://doi.org/10.3892/ol.2018.9878
MLA
Wang, J., Obulkasim, H., Zou, X., Liu, B., Wu, Y., Wu, X., Ding, Y."Neoadjuvant chemoradiotherapy followed by liver transplantation is a promising treatment for patients with unresectable hilar cholangiocarcinoma: A case report". Oncology Letters 17.2 (2019): 2069-2074.
Chicago
Wang, J., Obulkasim, H., Zou, X., Liu, B., Wu, Y., Wu, X., Ding, Y."Neoadjuvant chemoradiotherapy followed by liver transplantation is a promising treatment for patients with unresectable hilar cholangiocarcinoma: A case report". Oncology Letters 17, no. 2 (2019): 2069-2074. https://doi.org/10.3892/ol.2018.9878
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Obulkasim H, Zou X, Liu B, Wu Y, Wu X and Ding Y: Neoadjuvant chemoradiotherapy followed by liver transplantation is a promising treatment for patients with unresectable hilar cholangiocarcinoma: A case report. Oncol Lett 17: 2069-2074, 2019.
APA
Wang, J., Obulkasim, H., Zou, X., Liu, B., Wu, Y., Wu, X., & Ding, Y. (2019). Neoadjuvant chemoradiotherapy followed by liver transplantation is a promising treatment for patients with unresectable hilar cholangiocarcinoma: A case report. Oncology Letters, 17, 2069-2074. https://doi.org/10.3892/ol.2018.9878
MLA
Wang, J., Obulkasim, H., Zou, X., Liu, B., Wu, Y., Wu, X., Ding, Y."Neoadjuvant chemoradiotherapy followed by liver transplantation is a promising treatment for patients with unresectable hilar cholangiocarcinoma: A case report". Oncology Letters 17.2 (2019): 2069-2074.
Chicago
Wang, J., Obulkasim, H., Zou, X., Liu, B., Wu, Y., Wu, X., Ding, Y."Neoadjuvant chemoradiotherapy followed by liver transplantation is a promising treatment for patients with unresectable hilar cholangiocarcinoma: A case report". Oncology Letters 17, no. 2 (2019): 2069-2074. https://doi.org/10.3892/ol.2018.9878
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