Open Access

The long non‑coding RNA LINC00460 predicts the prognosis and promotes the proliferation and migration of cells in bladder urothelial carcinoma

  • Authors:
    • Lijie Wen
    • Xiling Zhang
    • Jing Bian
    • Li Han
    • Haibo Huang
    • Miao He
    • Minjie Wei
    • Ping Wang
  • View Affiliations

  • Published online on: February 7, 2019     https://doi.org/10.3892/ol.2019.10023
  • Pages: 3874-3880
  • Copyright: © Wen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Long non‑coding RNAs (lncRNAs) may serve an important role in cancer development and may also be suitable for use as prognostic biomarkers. At present, the role of lncRNAs in bladder cancer remains unclear. The present study examined the potential involvement of lncRNA LINC00460 in bladder urothelial carcinoma using data from The Caner Genome Atlas (TCGA) and cell line experiments. The results indicated that LINC00460 expression levels were increased in bladder urothelial carcinoma tissues and bladder cancer 5637 and T24 cell lines compared with corresponding normal controls (P<0.05). TCGA data indicated that LINC00460 expression was negatively correlated with a positive prognosis in patients with bladder urothelial carcinoma (P<0.05). Consistently, the downregulation of LINC00460 with short hairpin RNA significantly suppressed 5637 and T24 cell proliferation and migration. Therefore, it was suggested that strategies that target LINC00460 may be developed as novel therapeutic approaches for the treatment of bladder cancer. In addition, the expression level of androgen receptor (AR) was downregulated in bladder urothelial carcinoma tissues and exhibited a negative correlation with the expression level of LINC00460 (r=‑0.43; P<0.0001), based on the data from TCGA. We hypothesized that LINC00460 may serve an oncogenic role by regulating the expression of AR.
View Figures
View References

Related Articles

Journal Cover

April-2019
Volume 17 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wen L, Zhang X, Bian J, Han L, Huang H, He M, Wei M and Wang P: The long non‑coding RNA LINC00460 predicts the prognosis and promotes the proliferation and migration of cells in bladder urothelial carcinoma. Oncol Lett 17: 3874-3880, 2019
APA
Wen, L., Zhang, X., Bian, J., Han, L., Huang, H., He, M. ... Wang, P. (2019). The long non‑coding RNA LINC00460 predicts the prognosis and promotes the proliferation and migration of cells in bladder urothelial carcinoma. Oncology Letters, 17, 3874-3880. https://doi.org/10.3892/ol.2019.10023
MLA
Wen, L., Zhang, X., Bian, J., Han, L., Huang, H., He, M., Wei, M., Wang, P."The long non‑coding RNA LINC00460 predicts the prognosis and promotes the proliferation and migration of cells in bladder urothelial carcinoma". Oncology Letters 17.4 (2019): 3874-3880.
Chicago
Wen, L., Zhang, X., Bian, J., Han, L., Huang, H., He, M., Wei, M., Wang, P."The long non‑coding RNA LINC00460 predicts the prognosis and promotes the proliferation and migration of cells in bladder urothelial carcinoma". Oncology Letters 17, no. 4 (2019): 3874-3880. https://doi.org/10.3892/ol.2019.10023