Open Access

F‑box/WD‑40 repeat‑containing protein 7: A potential target in the progression and treatment of gastrointestinal malignancy (Review)

  • Authors:
    • Yizhi Wang
    • Yang An
    • Yi Ma
    • Junchao Guo
  • View Affiliations

  • Published online on: February 13, 2019     https://doi.org/10.3892/ol.2019.10036
  • Pages: 3625-3634
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cancer is a principal cause of human morbidity and mortality, with gastrointestinal malignancies, in particular, resulting in a marked number of tumor‑associated mortalities. The progression of gastrointestinal malignancy is regulated by a variety of aberrantly expressed proteins, a number of which facilitate tumor progression, whereas, others function as tumor suppressors. The detection of such proteins not only contributes to the early diagnosis of cancer, they may additionally serve as potential therapeutic targets. In normal tissues, numerous proteins encoded by proto‑oncoproteins are degraded by ubiquitylation enzymes, consisting of F‑box/WD‑40 repeat‑containing protein 7 (Fbw7) and other proteins, thus avoiding tumorigenesis and maintaining homeostasis. In tumor tissues, the downregulation of Fbw7, caused by various factors, leads to disorders in ubiquitinase synthesis, which may induce tumor progression and chemoresistance, particularly in gastrointestinal malignancy. Therefore, an in‑depth study of the regulatory mechanisms involved in disorders of Fbw7 expression and the role of Fbw7 in chemoresistance of gastrointestinal tumors may suggest improvements for early diagnostic screening and targeted therapy.
View Figures
View References

Related Articles

Journal Cover

April-2019
Volume 17 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, An Y, Ma Y and Guo J: F‑box/WD‑40 repeat‑containing protein 7: A potential target in the progression and treatment of gastrointestinal malignancy (Review). Oncol Lett 17: 3625-3634, 2019
APA
Wang, Y., An, Y., Ma, Y., & Guo, J. (2019). F‑box/WD‑40 repeat‑containing protein 7: A potential target in the progression and treatment of gastrointestinal malignancy (Review). Oncology Letters, 17, 3625-3634. https://doi.org/10.3892/ol.2019.10036
MLA
Wang, Y., An, Y., Ma, Y., Guo, J."F‑box/WD‑40 repeat‑containing protein 7: A potential target in the progression and treatment of gastrointestinal malignancy (Review)". Oncology Letters 17.4 (2019): 3625-3634.
Chicago
Wang, Y., An, Y., Ma, Y., Guo, J."F‑box/WD‑40 repeat‑containing protein 7: A potential target in the progression and treatment of gastrointestinal malignancy (Review)". Oncology Letters 17, no. 4 (2019): 3625-3634. https://doi.org/10.3892/ol.2019.10036