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Article Open Access

miR‑140‑3p inhibits breast cancer proliferation and migration by directly regulating the expression of tripartite motif 28

  • Authors:
    • Yu Zhou
    • Bo Wang
    • Yu Wang
    • Gaohui Chen
    • Qixin Lian
    • Haidong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China, Department of Anorectal Surgery, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China, Department of Oncology, Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China, Department of General Surgery, Daqing City People's Hospital, Daqing, Heilongjiang 163316, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3835-3841
    |
    Published online on: February 13, 2019
       https://doi.org/10.3892/ol.2019.10038
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Abstract

The present study aimed to determine the expression profile and significance of microRNA‑140‑3p (miR‑140‑3p) in breast cancer (BC). miR‑140‑3p expression in BC tumor tissues and cell lines was measured by reverse transcription‑ quantitative polymerase chain reaction. Luciferase activity reporter assay and western blotting were used to assess the effect of miR‑140‑3p expression on tripartite motif 28 (TRIM28). Cell growth, migration, and invasion were assessed by Cell Counting Kit‑8 assay, wound‑healing assay and Transwell invasion assay, respectively. miR‑140‑3p expression was significantly reduced in BC tumor tissues compared with in adjacent normal tissues. Additionally, low miR‑140‑3p expression was found to predict poor prognosis of patients with BC. TRIM28 expression was significantly reduced by miR‑140‑3p overexpression in BC cell lines, and was inversely correlated with miR‑140‑3p in BC tissues. Overexpression of miR‑140‑3p also inhibited cell proliferation, migration and invasion compared with in the control group. In conclusion, the present study revealed that miR‑140‑3p inhibited the progression of BC partially by regulating TRIM28.
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1 

DeSantis C, Ma J, Bryan L and Jemal A: Breast cancer statistics, 2013. CA Cancer J Clin. 64:52–62. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Tzanninis IG, Kotteas EA, Ntanasis-Stathopoulos I, Kontogianni P and Fotopoulos G: Management and outcomes in metaplastic breast cancer. Clin Breast Cancer. 16:437–443. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Sonnenblick A, Pondé N and Piccart M: Metastatic breast cancer: The Odyssey of personalization. Mol Oncol. 10:1147–1159. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Hemmatzadeh M, Mohammadi H, Jadidi-Niaragh F, Asghari F and Yousefi M: The role of oncomirs in the pathogenesis and treatment of breast cancer. Biomed Pharmacother. 78:129–139. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Asghari F, Haghnavaz N, Baradaran B, Hemmatzadeh M and Kazemi T: Tumor suppressor microRNAs: Targeted molecules and signaling pathways in breast cancer. Biomed Pharmacother. 81:305–317. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL and Massagué J: Endogenous human microRNAs that suppress breast cancer metastasis. Nature. 451:147–152. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Gravgaard KH, Lyng MB, Laenkholm AV, Søkilde R, Nielsen BS, Litman T and Ditzel HJ: The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer. Breast Cancer Res Treat. 134:207–217. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Korpal M, Lee ES, Hu G and Kang Y: The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 283:14910–14914. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Elliman SJ, Howley BV, Mehta DS, Fearnhead HO, Kemp DM and Barkley LR: Selective repression of the oncogene cyclin D1 by the tumor suppressor miR-206 in cancers. Oncogenesis. 3:e1132014. View Article : Google Scholar : PubMed/NCBI

12 

Song G, Zhang Y and Wang L: MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation. J Biol Chem. 284:31921–31927. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Kong XM, Zhang GH, Huo YK, Zhao XH, Cao DW, Guo SF, Li AM and Zhang XR: MicroRNA-140-3p inhibits proliferation, migration and invasion of lung cancer cells by targeting ATP6AP2. Int J Clin Exp Pathol. 8:12845–12852. 2015.PubMed/NCBI

14 

Zou MX, Huang W, Wang XB, Lv GH, Li J and Deng YW: Identification of miR-140-3p as a marker associated with poor prognosis in spinal chordoma. Int J Clin Exp Pathol. 7:4877–4885. 2014.PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Hao L, Leng J, Xiao R, Kingsley T, Li X, Tu Z, Yang X, Deng X, Xiong M, Xiong J and Zhang Q: Bioinformatics analysis of the prognostic value of Tripartite Motif 28 in breast cancer. Oncol Lett. 13:2670–2678. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Wei C, Cheng J, Zhou B, Zhu L, Khan MA, He T, Zhou S, He J, Lu X, Chen H, et al: Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein. Sci Rep. 6:298222016. View Article : Google Scholar : PubMed/NCBI

18 

Qi Z, Cai S, Cai J, Chen L, Yao Y, Chen L and Mao Y: miR-491 regulates glioma cells proliferation by targeting TRIM28 in vitro. BMC Neurol. 16:2482016. View Article : Google Scholar : PubMed/NCBI

19 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Rodriguez A, Griffiths-Jones S, Ashurst JL and Bradley A: Identification of mammalian microRNA host genes and transcription units. Genome Res. 14:1902–1910. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Fang Z, Yin S, Sun R, Zhang S, Fu M, Wu Y, Zhang T, Khaliq J and Li Y: miR-140-5p suppresses the proliferation, migration and invasion of gastric cancer by regulating YES1. Mol Cancer. 16:1392017. View Article : Google Scholar : PubMed/NCBI

22 

Lu Y, Qin T, Li J, Wang L, Zhang Q, Jiang Z and Mao J: MicroRNA-140-5p inhibits invasion and angiogenesis through targeting VEGF-A in breast cancer. Cancer Gene Ther. 24:386–392. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Lan H, Chen W, He G and Yang S: miR-140-5p inhibits ovarian cancer growth partially by repression of PDGFRA. Biomed Pharmacother. 75:117–122. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Hatakeyama S: TRIM proteins and cancer. Nat Rev Cancer. 11:792–804. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Chen L, Chen DT, Kurtyka C, Rawal B, Fulp WJ, Haura EB and Cress WD: Tripartite motif containing 28 (Trim28) can regulate cell proliferation by bridging HDAC1/E2F interactions. J Biol Chem. 287:40106–40118. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou Y, Wang B, Wang Y, Chen G, Lian Q and Wang H: miR‑140‑3p inhibits breast cancer proliferation and migration by directly regulating the expression of tripartite motif 28. Oncol Lett 17: 3835-3841, 2019.
APA
Zhou, Y., Wang, B., Wang, Y., Chen, G., Lian, Q., & Wang, H. (2019). miR‑140‑3p inhibits breast cancer proliferation and migration by directly regulating the expression of tripartite motif 28. Oncology Letters, 17, 3835-3841. https://doi.org/10.3892/ol.2019.10038
MLA
Zhou, Y., Wang, B., Wang, Y., Chen, G., Lian, Q., Wang, H."miR‑140‑3p inhibits breast cancer proliferation and migration by directly regulating the expression of tripartite motif 28". Oncology Letters 17.4 (2019): 3835-3841.
Chicago
Zhou, Y., Wang, B., Wang, Y., Chen, G., Lian, Q., Wang, H."miR‑140‑3p inhibits breast cancer proliferation and migration by directly regulating the expression of tripartite motif 28". Oncology Letters 17, no. 4 (2019): 3835-3841. https://doi.org/10.3892/ol.2019.10038
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Y, Wang B, Wang Y, Chen G, Lian Q and Wang H: miR‑140‑3p inhibits breast cancer proliferation and migration by directly regulating the expression of tripartite motif 28. Oncol Lett 17: 3835-3841, 2019.
APA
Zhou, Y., Wang, B., Wang, Y., Chen, G., Lian, Q., & Wang, H. (2019). miR‑140‑3p inhibits breast cancer proliferation and migration by directly regulating the expression of tripartite motif 28. Oncology Letters, 17, 3835-3841. https://doi.org/10.3892/ol.2019.10038
MLA
Zhou, Y., Wang, B., Wang, Y., Chen, G., Lian, Q., Wang, H."miR‑140‑3p inhibits breast cancer proliferation and migration by directly regulating the expression of tripartite motif 28". Oncology Letters 17.4 (2019): 3835-3841.
Chicago
Zhou, Y., Wang, B., Wang, Y., Chen, G., Lian, Q., Wang, H."miR‑140‑3p inhibits breast cancer proliferation and migration by directly regulating the expression of tripartite motif 28". Oncology Letters 17, no. 4 (2019): 3835-3841. https://doi.org/10.3892/ol.2019.10038
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