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Article

Investigation of the clonal origin of multifocal papillary thyroid carcinoma according to the X‑chromosome inactivation pattern

  • Authors:
    • Dan Chen
    • Wenjing Qi
    • Suling Xie
    • Lu Feng
    • Junying Wang
    • Lifen Wang
    • Hongwei Guan
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116001, P.R. China, Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China
  • Pages: 4695-4700
    |
    Published online on: March 4, 2019
       https://doi.org/10.3892/ol.2019.10105
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Abstract

Patients with papillary thyroid carcinoma (PTC) usually have multiple tumors, or foci. It remains unclear if these foci originate from independent tumors or a single tumor mass. The present study included 89 female patients with bilateral PTC who had been treated with a total thyroidectomy. An X‑chromosome inactivation assay was used to examine the clonal origin of the tumors according to the status of the X‑linked human androgen receptor gene. Of the 89 patients, 5 were informative. The X‑chromosome inactivation pattern was the same in multiple foci in 3 cases, indicating a monoclonal origin of the tumors. In 1 case, the X chromosome inactivation pattern was different between the tumors. Mixed patterns were observed in 1 case. The results of the present study suggest that in certain cases of multifocal PTC, tumors arise independently, whereas in other cases, separate foci are the outcome of intra‑thyroid spread by a single tumor mass.
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Copy and paste a formatted citation
Spandidos Publications style
Chen D, Qi W, Xie S, Feng L, Wang J, Wang L and Guan H: Investigation of the clonal origin of multifocal papillary thyroid carcinoma according to the X‑chromosome inactivation pattern. Oncol Lett 17: 4695-4700, 2019.
APA
Chen, D., Qi, W., Xie, S., Feng, L., Wang, J., Wang, L., & Guan, H. (2019). Investigation of the clonal origin of multifocal papillary thyroid carcinoma according to the X‑chromosome inactivation pattern. Oncology Letters, 17, 4695-4700. https://doi.org/10.3892/ol.2019.10105
MLA
Chen, D., Qi, W., Xie, S., Feng, L., Wang, J., Wang, L., Guan, H."Investigation of the clonal origin of multifocal papillary thyroid carcinoma according to the X‑chromosome inactivation pattern". Oncology Letters 17.5 (2019): 4695-4700.
Chicago
Chen, D., Qi, W., Xie, S., Feng, L., Wang, J., Wang, L., Guan, H."Investigation of the clonal origin of multifocal papillary thyroid carcinoma according to the X‑chromosome inactivation pattern". Oncology Letters 17, no. 5 (2019): 4695-4700. https://doi.org/10.3892/ol.2019.10105
Copy and paste a formatted citation
x
Spandidos Publications style
Chen D, Qi W, Xie S, Feng L, Wang J, Wang L and Guan H: Investigation of the clonal origin of multifocal papillary thyroid carcinoma according to the X‑chromosome inactivation pattern. Oncol Lett 17: 4695-4700, 2019.
APA
Chen, D., Qi, W., Xie, S., Feng, L., Wang, J., Wang, L., & Guan, H. (2019). Investigation of the clonal origin of multifocal papillary thyroid carcinoma according to the X‑chromosome inactivation pattern. Oncology Letters, 17, 4695-4700. https://doi.org/10.3892/ol.2019.10105
MLA
Chen, D., Qi, W., Xie, S., Feng, L., Wang, J., Wang, L., Guan, H."Investigation of the clonal origin of multifocal papillary thyroid carcinoma according to the X‑chromosome inactivation pattern". Oncology Letters 17.5 (2019): 4695-4700.
Chicago
Chen, D., Qi, W., Xie, S., Feng, L., Wang, J., Wang, L., Guan, H."Investigation of the clonal origin of multifocal papillary thyroid carcinoma according to the X‑chromosome inactivation pattern". Oncology Letters 17, no. 5 (2019): 4695-4700. https://doi.org/10.3892/ol.2019.10105
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