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Article

Randomized controlled trial of lobaplatin plus etoposide vs. cisplatin plus etoposide as first‑line therapy in patients with extensive‑stage small cell lung cancer

  • Authors:
    • Ying Cheng
    • Yun Fan
    • Xiaoqing Liu
    • Yunpeng Liu
    • Jiwei Liu
    • Dong Wang
    • Yan Yu
    • Shukui Qin
    • Wei Liu
    • Cheng Huang
    • Helong Zhang
    • Jun Liang
    • Jianhua Shi
    • Lijun Sheng
    • Hao Yu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Jilin Cancer Hospital, Changchun, Jilin 130021, P.R. China, Department of Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Department of Chest Tumor, 307th Hospital of The Academy of Military Medical Sciences, Beijing 100071, P.R. China, Department of Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Oncology, The Daping Hospital of Third Military Medical University, Chongqing 400042, P.R. China, Department of Oncology, The Cancer Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China, Department of Oncology, People's Liberation Army Cancer Center of Nanjing 81 Hospital, Nanjing, Jiangsu 210002, P.R. China, Department of Oncology, Hebei Cancer Hospital, Shijiazhuang, Hebei 050011, P.R. China, Department of Oncology, Fujian Province Cancer Hospital, Fuzhou, Fujian 350014, P.R. China, Department of Oncology, The Tangdu Hospital of Fourth Military Medical University, Xi'an, Shanxi 710038, P.R. China, Department of Oncology, Peking University International Hospital, Peking University, Beijing 102206, P.R. China, Department of Oncology, Linyi Cancer Hospital, Linyi, Shandong 251500, P.R. China, Department of Oncology, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, Shandong 250031, P.R. China, Department of Biostatistics, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China
  • Pages: 4701-4709
    |
    Published online on: March 8, 2019
       https://doi.org/10.3892/ol.2019.10125
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Abstract

The majority of previous studies of lobaplatin in small cell lung cancer (SCLC) are small phase I‑II studies. The present study aimed to verify the non‑inferiority (in terms of efficacy) of lobaplatin plus etoposide (EL) vs. cisplatin plus etoposide (EP) in patients with previously untreated extensive‑stage SCLC (ES‑SCLC). This phase III non‑inferiority randomized clinical trial enrolled patients at 17 sites between September 2010 and May 2013. Patients were randomized to EL (30 mg/m2 lobaplatin on day 1 and 100 mg/m2 etoposide on days 1‑3, for 21‑day cycles) or EP (80 mg/m2 cisplatin on day 1 and 100 mg/m2 etoposide on days 1‑3, for 21‑day cycles). The primary endpoint was progression‑free survival (PFS). Secondary endpoints included overall survival (OS), objective response rate, disease control rate (DCR), toxicity and quality of life (QoL). A total of 234 patients were randomized to the EL (n=122) and EP (n=112) treatment groups. The median PFS, median OS and DCR were 5.1 vs. 5.3 months (P=0.786), 10.6 vs. 9.7 months (P=0.701) and 85.5 vs. 86.7% (P=0.848) in the EL vs. EP groups, respectively. Patients in the EL group had significantly lower frequencies of nephrotoxicity (2.5 vs. 11.7%; P=0.008), nausea (22.3 vs. 40.5%; P=0.003) and vomiting (14.1 vs. 35.1%; P<0.001) than those in the EP group. Overall, EL was not inferior to EP in terms of PFS and OS. The tolerance and QoL of the EL regimen were better than those of the EP regimen. EL is thus an alternative choice for the first‑line treatment of ES‑SCLC.
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View References

1 

Howlader N, Noone A and Krapcho M: SEER cancer statistics review, 1975–2013, based on November 2015 SEER data submission, posted to the SEER web site, April 2016. Bethesda: National Cancer Institute; 2016

2 

Pietanza MC, Byers LA, Minna JD and Rudin CM: Small cell lung cancer: Will recent progress lead to improved outcomes? Clin Cancer Res. 21:2244–2255. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Seiter K: Toxicity of the topoisomerase II inhibitors. Expert Opin Drug Saf. 4:219–234. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Hayati F, Hossainzadeh M, Shayanpour S, Abedi-Gheshlaghi Z and Beladi Mousavi SS: Prevention of cisplatin nephrotoxicity. J Nephropharmacol. 5:57–60. 2016.PubMed/NCBI

5 

McKeage MJ: Lobaplatin: A new antitumour platinum drug. Expert Opin Investig Drugs. 10:119–128. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Harstrick A, Bokemeyer C, Scharnofkse M, Hapke G, Reile D and Schmoll HJ: Preclinical activity of a new platinum analogue, lobaplatin, in cisplatin-sensitive and -resistant human testicular, ovarian, and gastric carcinoma cell lines. Cancer Chemother Pharmacol. 33:43–47. 1993. View Article : Google Scholar : PubMed/NCBI

7 

Liang Y, Sui X and Cheng Y: Clinical research progress of the new antitumor drug Lobaplatin in the treatment of small cell lung cancer. Chin J N Drugs. 23:184–188. 2014.

8 

Jakupec MA, Galanski M and Keppler BK: Tumour-inhibiting platinum complexes-state of the art and future perspectives. Rev Physiol Biochem Pharmacol. 146:1–54. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Monneret C: Platinum anticancer drugs. From serendipity to rational design. Ann Pharm Fr. 69:286–295. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Fiebig HH, Henss H, von Pawel I, Gatzemeier U, Manegold CH, Edler L and Berdel W: Phase II clinical trial of lobaplatin (D-19466) in pretreated patients with small-cell lung cancer. Onkologie. 19:328–332. 1996.

11 

Yang L and Qin S: Progression of Lobaplatin as the third generation platinum drug. Chin Clin Oncol. 14:1134–1139. 2009.

12 

De Vore RF: Chemotherapy for small cell lung cancer. Pass HI: Lung Cancer Principles and Practice. 2nd. Philadelphia: Lippincott Williams & Wilkins; 2000

13 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Satouchi M, Kotani Y, Shibata T, Ando M, Nakagawa K, Yamamoto N, Ichinose Y, Ohe Y, Nishio M, Hida T, et al: Phase III study comparing amrubicin plus cisplatin with irinotecan plus cisplatin in the treatment of extensive-disease small-cell lung cancer: JCOG 0509. J Clin Oncol. 32:1262–1268. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Russell SD, Saval MA, Robbins JL, Ellestad MH, Gottlieb SS, Handberg EM, Zhou Y and Chandler B: HF-ACTION Investigators: New York Heart Association functional class predicts exercise parameters in the current era. Am Heart J. 158 (4 Suppl):S24–S30. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Gietema JA, de Vries EG, Sleijfer DT, Willemse PH, Guchelaar HJ, Uges DR, Aulenbacher P, Voegeli R and Mulder NH: A phase I study of 1,2-diamminomethyl-cyclobutane-platinum (II)-lactate (D-19466; lobaplatin) administered daily for 5 days. Br J Cancer. 67:396–401. 1993. View Article : Google Scholar : PubMed/NCBI

17 

Fiebig HH, Henss H, Mross K, Meyberg F, Aulenbacher P, Burk K and Queißer W: Phase I clinical trial of lobaplatin (D-19466) after intravenous bolus injection. Onkologie. 17:142–148. 1994.

18 

Basch E, Iasonos A, McDonough T, Barz A, Culkin A, Kris MG, Scher HI and Schrag D: Patient versus clinician symptom reporting using the national cancer institute common terminology criteria for adverse events: Results of a questionnaire-based study. Lancet Oncol. 7:903–909. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Osoba D, Rodrigues G, Myles J, Zee B and Pater J: Interpreting the significance of changes in health-related quality-of-life scores. J Clin Oncol. 16:139–144. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Anderson H, Hopwood P, Stephens RJ, Thatcher N, Cottier B, Nicholson M, Milroy R, Maughan TS, Falk SJ, Bond MG, et al: Gemcitabine plus best supportive care (BSC) vs BSC in inoperable non-small cell lung cancer-a randomized trial with quality of life as the primary outcome. UK NSCLC Gemcitabine Group. Non-small cell lung cancer. Br J Cancer. 83:447–453. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Noda K, Nishiwaki Y, Kawahara M, Negoro S, Sugiura T, Yokoyama A, Fukuoka M, Mori K, Watanabe K, Tamura T, et al: Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med. 346:85–91. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Lara PN Jr, Natale R, Crowley J, Lenz HJ, Redman MW, Carleton JE, Jett J, Langer CJ, Kuebler JP, Dakhil SR, et al: Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer: Clinical and pharmacogenomic results from SWOG S0124. J Clin Oncol. 27:2530–2535. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Jung SH, Kang SJ, McCall LM and Blumenstein B: Sample size computation for two-sample noninferiority log-rank test. J Biopharm Stat. 15:969–979. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Lakatos E: Sample sizes based on the log-rank statistic in complex clinical trials. Biometrics. 44:229–241. 1988. View Article : Google Scholar : PubMed/NCBI

25 

Miller RP, Tadagavadi RK, Ramesh G and Reeves WB: Mechanisms of Cisplatin nephrotoxicity. Toxins (Basel). 2:2490–2518. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Chen MQ, Chen C, Lu HJ and Xu BH: The efficacy and toxicities of combined lobaplatin with paclitaxel as a first-line chemotherapy for advanced esophageal squamous cell carcinoma. J Thorac Dis. 7:1749–1755. 2015.PubMed/NCBI

27 

Yang JS, Wang T, Qiu MQ and Li QL: Comparison of efficacy and toxicity profiles between paclitaxel/lobapoatin- and cisplatin/5-fluorouracil-based concurrent chemoradiotherapy of advanced inoperable oesophageal cancer. Intern Med J. 45:757–761. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Li WP, Liu H, Chen L, Yao YQ and Zhao EF: A clinical comparison of lobaplatin or cisplatin with mitomycine and vincristine in treating patients with cervical squamous carcinoma. Asian Pac J Cancer Prev. 16:4629–4631. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Wang JQ, Wang T, Shi F, Yang YY, Su J, Chai YL and Liu Z: A randomized controlled trial comparing clinical outcomes and toxicity of lobaplatin-versus cisplatin-based concurrent chemotherapy plus radiotherapy and high-dose-rate brachytherapy for FIGO Stage II and III cervical cancer. Asian Pac J Cancer Prev. 16:5957–5961. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Mirsadraee S, Oswal D, Alizadeh Y, Caulo A and van Beek E Jr: The 7th lung cancer TNM classification and staging system: Review of the changes and implications. World J Radiol. 4:128–134. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cheng Y, Fan Y, Liu X, Liu Y, Liu J, Wang D, Yu Y, Qin S, Liu W, Huang C, Huang C, et al: Randomized controlled trial of lobaplatin plus etoposide vs. cisplatin plus etoposide as first‑line therapy in patients with extensive‑stage small cell lung cancer. Oncol Lett 17: 4701-4709, 2019.
APA
Cheng, Y., Fan, Y., Liu, X., Liu, Y., Liu, J., Wang, D. ... Yu, H. (2019). Randomized controlled trial of lobaplatin plus etoposide vs. cisplatin plus etoposide as first‑line therapy in patients with extensive‑stage small cell lung cancer. Oncology Letters, 17, 4701-4709. https://doi.org/10.3892/ol.2019.10125
MLA
Cheng, Y., Fan, Y., Liu, X., Liu, Y., Liu, J., Wang, D., Yu, Y., Qin, S., Liu, W., Huang, C., Zhang, H., Liang, J., Shi, J., Sheng, L., Yu, H."Randomized controlled trial of lobaplatin plus etoposide vs. cisplatin plus etoposide as first‑line therapy in patients with extensive‑stage small cell lung cancer". Oncology Letters 17.5 (2019): 4701-4709.
Chicago
Cheng, Y., Fan, Y., Liu, X., Liu, Y., Liu, J., Wang, D., Yu, Y., Qin, S., Liu, W., Huang, C., Zhang, H., Liang, J., Shi, J., Sheng, L., Yu, H."Randomized controlled trial of lobaplatin plus etoposide vs. cisplatin plus etoposide as first‑line therapy in patients with extensive‑stage small cell lung cancer". Oncology Letters 17, no. 5 (2019): 4701-4709. https://doi.org/10.3892/ol.2019.10125
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Y, Fan Y, Liu X, Liu Y, Liu J, Wang D, Yu Y, Qin S, Liu W, Huang C, Huang C, et al: Randomized controlled trial of lobaplatin plus etoposide vs. cisplatin plus etoposide as first‑line therapy in patients with extensive‑stage small cell lung cancer. Oncol Lett 17: 4701-4709, 2019.
APA
Cheng, Y., Fan, Y., Liu, X., Liu, Y., Liu, J., Wang, D. ... Yu, H. (2019). Randomized controlled trial of lobaplatin plus etoposide vs. cisplatin plus etoposide as first‑line therapy in patients with extensive‑stage small cell lung cancer. Oncology Letters, 17, 4701-4709. https://doi.org/10.3892/ol.2019.10125
MLA
Cheng, Y., Fan, Y., Liu, X., Liu, Y., Liu, J., Wang, D., Yu, Y., Qin, S., Liu, W., Huang, C., Zhang, H., Liang, J., Shi, J., Sheng, L., Yu, H."Randomized controlled trial of lobaplatin plus etoposide vs. cisplatin plus etoposide as first‑line therapy in patients with extensive‑stage small cell lung cancer". Oncology Letters 17.5 (2019): 4701-4709.
Chicago
Cheng, Y., Fan, Y., Liu, X., Liu, Y., Liu, J., Wang, D., Yu, Y., Qin, S., Liu, W., Huang, C., Zhang, H., Liang, J., Shi, J., Sheng, L., Yu, H."Randomized controlled trial of lobaplatin plus etoposide vs. cisplatin plus etoposide as first‑line therapy in patients with extensive‑stage small cell lung cancer". Oncology Letters 17, no. 5 (2019): 4701-4709. https://doi.org/10.3892/ol.2019.10125
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