Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2019 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2019 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma (Review)

  • Authors:
    • Yanmeng Li
    • Anjian Xu
    • Siyu Jia
    • Jian Huang
  • View Affiliations / Copyright

    Affiliations: Experimental Center, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China
  • Pages: 4222-4228
    |
    Published online on: March 8, 2019
       https://doi.org/10.3892/ol.2019.10127
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hepatocellular carcinoma (HCC) is more frequently observed and aggressive in men compared with women. Increasing evidence demonstrates that the sex disparity appears to be mediated by the stimulatory effects of androgens and the protective effects of estrogen in the development and progression of HCC. In the past few decades, studies on the sex difference of HCC mainly focused on the effect of sex hormones on the transactivation of hepatitis B virus X protein and the release of inflammatory cytokines, and these studies have further intensified in recent years. Sex hormones are also involved in genetic alterations and DNA damage repair in hepatocytes through binding to their specific cellular receptors and affecting the corresponding signaling pathways. Furthermore, the theory of sex chromosomes participating in HCC has been considered. The present review discussed the recent advances in the molecular mechanisms of sex disparity in HCC, with the aim of improving the understanding of the underlying critical factors and exploring more effective methods for the prevention and treatment of HCC.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Ascha MS, Hanouneh IA, Lopez R, Tamimi TA, Feldstein AF and Zein NN: The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology. 51:1972–1978. 2010. View Article : Google Scholar : PubMed/NCBI

3 

El-Serag HB: Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 142:1264–1273.e1. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Torre LA, Siegel RL, Ward EM and Jemal A: Global cancer incidence and mortality rates and trends-an update. Cancer Epidemiol Biomarkers Prev. 25:16–27. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM and Karin M: Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 317:121–124. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Wang SH, Yeh SH, Lin WH, Wang HY, Chen DS and Chen PJ: Identification of androgen response elements in the enhancer I of hepatitis B virus: A mechanism for sex disparity in chronic hepatitis B. Hepatology. 50:1392–1402. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Liu C, Ren YF, Dong J, Ke MY, Ma F, Monga SPS, Wu R, Lv Y and Zhang XF: Activation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma. Cancer Lett. 410:20–31. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Jiang HL, Xu D, Yu H, Ma X, Lin GF, Ma DY and Jin JZ: DAX-1 inhibits hepatocellular carcinoma proliferation by inhibiting β-catenin transcriptional activity. Cell Physiol Biochem. 34:734–742. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Chua HH, Tsuei DJ, Lee PH, Jeng YM, Lu J, Wu JF, Su DS, Chen YH, Chien CS, Kao PC, et al: RBMY, a novel inhibitor of glycogen synthase kinase 3β, increases tumor stemness and predicts poor prognosis of hepatocellular carcinoma. Hepatology. 62:1480–1496. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Bertani S, Pineau P, Loli S, Moura J, Zimic M, Deharo E and Ruiz E: An atypical age-specific pattern of hepatocellular carcinoma in Peru: A threat for Andean populations. PLoS One. 8:e677562013. View Article : Google Scholar : PubMed/NCBI

13 

Hassan MM, Botrus G, Abdel-Wahab R, Wolff RA, Li D, Tweardy D, Phan AT, Hawk E, Javle M, Lee JS, et al: Estrogen replacement reduces risk and increases survival times of women with hepatocellular carcinoma. Clin Gastroenterol Hepatol. 15:1791–1799. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Yu MW, Chang HC, Chang SC, Liaw YF, Lin SM, Liu CJ, Lee SD, Lin CL, Chen PJ, Lin SC and Chen CJ: Role of reproductive factors in hepatocellular carcinoma: Impact on hepatitis B- and C-related risk. Hepatology. 38:1393–1400. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Bigsby RM and Caperell-Grant A: The role for estrogen receptor-alpha and prolactin receptor in sex-dependent DEN-induced liver tumorigenesis. Carcinogenesis. 32:1162–1166. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Prieto J: Inflammation, HCC and sex: IL-6 in the centre of the triangle. J Hepatol. 48:380–381. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Wang YC, Xu GL, Jia WD, Han SJ, Ren WH, Wang W, Liu WB, Zhang CH and Chen H: Estrogen suppresses metastasis in rat hepatocellular carcinoma through decreasing interleukin-6 and hepatocyte growth factor expression. Inflammation. 35:143–149. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Coussens LM and Werb Z: Inflammation and cancer. Nature. 420:860–867. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Karin M: Nuclear factor-kappaB in cancer development and progression. Nature. 441:431–436. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Shi L, Feng Y, Lin H, Ma R and Cai X: Role of estrogen in hepatocellular carcinoma: Is inflammation the key? J Transl Med. 12:932014. View Article : Google Scholar : PubMed/NCBI

21 

Ren J, Chen GG, Liu Y, Su X, Hu B, Leung BC, Wang Y, Ho RL, Yang S, Lu G, et al: Cytochrome P450 1A2 metabolizes 17β-estradiol to suppress hepatocellular carcinoma. PLoS One. 11:e01538632016. View Article : Google Scholar : PubMed/NCBI

22 

Zheng B, Zhu YJ, Wang HY and Chen L: Gender disparity in hepatocellular carcinoma (HCC): Multiple underlying mechanisms. Sci China Life Sci. 60:575–584. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Teng Y, Litchfield LM, Ivanova MM, Prough RA, Clark BJ and Klinge CM: Dehydroepiandrosterone-induces miR-21 transcription in HepG2 cells through estrogen receptor β and androgen receptor. Mol Cell Endocrinol. 392:23–36. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Shen M, Cao J and Shi H: Effects of estrogen and estrogen receptors on transcriptomes of HepG2 Cells: A preliminary study using RNA sequencing. Int J Endocrinol. 2018:57891272018. View Article : Google Scholar : PubMed/NCBI

25 

Shen M and Shi H: Estradiol and estrogen receptor agonists oppose oncogenic actions of leptin in HepG2 cells. PLoS One. 11:e01514552016. View Article : Google Scholar : PubMed/NCBI

26 

Pearce ST and Jordan VC: The biological role of estrogen receptors alpha and beta in cancer. Crit Rev Oncol Hematol. 50:3–22. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Iyer JK, Kalra M, Kaul A, Payton ME and Kaul R: Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis. World J Gastroenterol. 23:6802–6816. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Xu H, Wei Y, Zhang Y, Xu Y, Li F, Liu J, Zhang W, Han X, Tan R and Shen P: Oestrogen attenuates tumour progression in hepatocellular carcinoma. J Pathol. 228:216–229. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Wei Q, Guo P, Mu K, Zhang Y, Zhao W, Huai W, Qiu Y, Li T, Ma X, Liu Y, et al: Estrogen suppresses hepatocellular carcinoma cells through ERβ-mediated upregulation of the NLRP3 inflammasome. Lab Invest. 95:804–816. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Hou J, Xu J, Jiang R, Wang Y, Chen C, Deng L, Huang X, Wang X and Sun B: Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3. Hepatology. 57:678–688. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Yang W, Lu Y, Xu Y, Xu L, Zheng W, Wu Y, Li L and Shen P: Estrogen represses hepatocellular carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages (TAMs). J Biol Chem. 287:40140–40149. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Deng L, Yang H, Tang J, Lin Z, Yin A, Gao Y, Wang X, Jiang R and Sun B: Inhibition of MTA1 by ERα contributes to protection hepatocellular carcinoma from tumor proliferation and metastasis. J Exp Clin Cancer Res. 34:1282015. View Article : Google Scholar : PubMed/NCBI

33 

Lin YM, Velmurugan BK, Yeh YL, Tu CC, Ho TJ, Lai TY, Tsai CH, Tsai FJ, Tsai CH and Huang CY: Activation of estrogen receptors with E2 downregulates peroxisome proliferator-activated receptor γ in hepatocellular carcinoma. Oncol Rep. 30:3027–3031. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Bartel DP and Chen CZ: Micromanagers of gene expression: The potentially widespread influence of metazoan microRNAs. Nat Rev Genet. 5:396–400. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Amodio G, Sasso E, D'Ambrosio C, Scaloni A, Moltedo O, Franceschelli S, Zambrano N and Remondelli P: Identification of a microRNA (miR-663a) induced by ER stress and its target gene PLOD3 by a combined microRNome and proteome approach. Cell Biol Toxicol. 32:285–303. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Sun L, Guo Z, Sun J, Li J, Dong Z, Zhang Y, Chen J, Kan Q and Yu Z: MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-β/Smad3 signaling pathway. Biomed Pharmacother. 107:168–176. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Ladeiro Y, Couchy G, Balabaud C, Bioulac-Sage P, Pelletier L, Rebouissou S and Zucman-Rossi J: MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology. 47:1955–1963. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Chen PJ, Yeh SH, Liu WH, Lin CC, Huang HC, Chen CL, Chen DS and Chen PJ: Androgen pathway stimulates microRNA-216a transcription to suppress the tumor suppressor in lung cancer-1 gene in early hepatocarcinogenesis. Hepatology. 56:632–643. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Sun J, Lu H, Wang X and Jin H: MicroRNAs in hepatocellular carcinoma: Regulation, function, and clinical implications. ScientificWorldJournal. 2013:9242062013. View Article : Google Scholar : PubMed/NCBI

40 

Marchesi F, Regazzo G, Palombi F, Terrenato I, Sacconi A, Spagnuolo M, Donzelli S, Marino M, Ercolani C, Di Benedetto A, et al: Serum miR-22 as potential non-invasive predictor of poor clinical outcome in newly diagnosed, uniformly treated patients with diffuse large B-cell lymphoma: An explorative pilot study. J Exp Clin Cancer Res. 37:952018. View Article : Google Scholar : PubMed/NCBI

41 

Jiang R, Deng L, Zhao L, Li X, Zhang F, Xia Y, Gao Y, Wang X and Sun B: miR-22 promotes HBV-related hepatocellular carcinoma development in males. Clin Cancer Res. 17:5593–5603. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Liu WH, Yeh SH, Lu CC, Yu SL, Chen HY, Lin CY, Chen DS and Chen PJ: MicroRNA-18a prevents estrogen receptor-alpha expression, promoting proliferation of hepatocellular carcinoma cells. Gastroenterology. 136:683–693. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Li CL, Yeh KH, Liu WH, Chen CL, Chen DS, Chen PJ and Yeh SH: Elevated p53 promotes the processing of miR-18a to decrease estrogen receptor-α in female hepatocellular carcinoma. Int J Cancer. 136:761–770. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Luu-The V: Assessment of steroidogenesis and steroidogenic enzyme functions. J Steroid Biochem Mol Biol. 137:176–182. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Niu ZS, Niu XJ and Wang WH: Genetic alterations in hepatocellular carcinoma: An update. World J Gastroenterol. 22:9069–9095. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Aleksic K, Lackner C, Geigl JB, Schwarz M, Auer M, Ulz P, Fischer M, Trajanoski Z, Otte M and Speicher MR: Evolution of genomic instability in diethylnitrosamine-induced hepatocarcinogenesis in mice. Hepatology. 53:895–904. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Na TY, Ka NL, Rhee H, Kyeong D, Kim MH, Seong JK, Park YN and Lee MO: Interaction of hepatitis B virus X protein with PARP1 results in inhibition of DNA repair in hepatocellular carcinoma. Oncogene. 35:5435–5445. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Zhao Z, Chen GY, Long J, Li H and Huang J: Genomic losses at 5q13.2 and 8p23.1 in dysplastic hepatocytes are common events in hepatitis B virus-related hepatocellular carcinoma. Oncol Lett. 9:2839–2846. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Tummala KS, Gomes AL, Yilmaz M, Graña O, Bakiri L, Ruppen I, Ximénez-Embún P, Sheshappanavar V, Rodriguez-Justo M, Pisano DG, et al: Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage. Cancer Cell. 26:826–839. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Mazzotta A, Partipilo G, De Summa S, Giotta F, Simone G and Mangia A: Nuclear PARP1 expression and its prognostic significance in breast cancer patients. Tumour Biol. 37:6143–6153. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Markaverich BM, Shoulars K and Rodriguez MA: Luteolin regulation of estrogen signaling and cell cycle pathway genes in MCF-7 human breast cancer cells. Int J Biomed Sci. 7:101–111. 2011.PubMed/NCBI

52 

Dantzer F, Schreiber V, Niedergang C, Trucco C, Flatter E, De La Rubia G, Oliver J, Rolli V, Ménissier-de Murcia J and de Murcia G: Involvement of poly(ADP-ribose) polymerase in base excision repair. Biochimie. 81:69–75. 1999. View Article : Google Scholar : PubMed/NCBI

53 

Song D, Huang H, Wang J, Zhao Y, Hu X, He F, Yu L and Wu J: NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma. Biochem Biophys Res Commun. 488:211–217. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Ko HL and Ren EC: Novel poly (ADP-ribose) polymerase 1 binding motif in hepatitis B virus core promoter impairs DNA damage repair. Hepatology. 54:1190–1198. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Mukherjee RM, Shravanti GV, Jakkampudi A, Kota R, Jangala AL, Reddy PB, Rao PN, Gupta R and Reddy DN: Reduced expression of DNA damage repair genes high mobility group box1 and Poly(ADP-ribose) polymerase1 in inactive carriers of hepatitis B virus infection-A possible stage of viral integration. J Clin Exp Hepatol. 3:89–95. 2013. View Article : Google Scholar : PubMed/NCBI

56 

Qadri I, Fatima K and AbdeL-Hafiz H: Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH. BMC Microbiol. 11:482011. View Article : Google Scholar : PubMed/NCBI

57 

Hashimoto S and Egly JM: Trichothiodystrophy view from the molecular basis of DNA repair/transcription factor TFIIH. Hum Mol Genet. 18:R224–R230. 2009. View Article : Google Scholar : PubMed/NCBI

58 

Schärer OD: Hot topics in DNA repair: The molecular basis for different disease states caused by mutations in TFIIH and XPG. DNA Repair (Amst). 7:339–344. 2008. View Article : Google Scholar : PubMed/NCBI

59 

Lee TH, Elledge SJ and Butel JS: Hepatitis B virus X protein interacts with a probable cellular DNA repair protein. J Virol. 69:1107–1114. 1995.PubMed/NCBI

60 

Djouder N: Boosting NAD(+) for the prevention and treatment of liver cancer. Mol Cell Oncol. 2:e10011992015. View Article : Google Scholar : PubMed/NCBI

61 

Boniol M and Autier P: Prevalence of main cancer lifestyle risk factors in Europe in 2000. Eur J Cancer. 46:2534–2544. 2010. View Article : Google Scholar : PubMed/NCBI

62 

Grohmann M, Wiede F, Dodd GT, Gurzov EN, Ooi GJ, Butt T, Rasmiena AA, Kaur S, Gulati T, Goh PK, et al: Obesity drives STAT-1-dependent NASH and STAT-3-dependent HCC. Cell. 175:1289–1306 e20. 2018. View Article : Google Scholar : PubMed/NCBI

63 

Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H and Karin M: Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 140:197–208. 2010. View Article : Google Scholar : PubMed/NCBI

64 

Xiong Y, Zhang J, Liu M, An M, Lei L and Guo W: Human leptin protein activates the growth of HepG2 cells by inhibiting PERK-mediated ER stress and apoptosis. Mol Med Rep. 10:1649–1655. 2014. View Article : Google Scholar : PubMed/NCBI

65 

Vansaun MN, Mendonsa AM and Lee Gorden D: Hepatocellular proliferation correlates with inflammatory cell and cytokine changes in a murine model of nonalchoholic fatty liver disease. PLoS One. 8:e730542013. View Article : Google Scholar : PubMed/NCBI

66 

Li S, Mo C, Huang S, Yang S, Lu Y, Peng Q, Wang J, Deng Y, Qin X and Liu Y: Over-expressed Testis-specific Protein Y-encoded 1 as a novel biomarker for male hepatocellular carcinoma. PLoS One. 9:e892192014. View Article : Google Scholar : PubMed/NCBI

67 

Montella M, D'Arena G, Crispo A, Capunzo M, Nocerino F, Grimaldi M, Barbieri A, D'Ursi AM, Tecce MF, Amore A, et al: Role of sex hormones in the development and progression of hepatitis B virus-associated hepatocellular carcinoma. Int J Endocrinol. 2015:8545302015. View Article : Google Scholar : PubMed/NCBI

68 

Beato M and Klug J: Steroid hormone receptors: An update. Hum Reprod Update. 6:225–236. 2000. View Article : Google Scholar : PubMed/NCBI

69 

Chang CS, Kokontis J and Liao ST: Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science. 240:324–326. 1988. View Article : Google Scholar : PubMed/NCBI

70 

Wu MH, Ma WL, Hsu CL, Chen YL, Ou JH, Ryan CK, Hung YC, Yeh S and Chang C: Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription. Sci Transl Med. 2:32ra352010. View Article : Google Scholar : PubMed/NCBI

71 

Barone M, Margiotta M, Scavo MP, Gentile A, Francioso D, Papagni S, Castellaneta A, Mallamaci R, Di Leo A and Francavilla A: Possible involvement of androgen receptor alterations in hepatocarcinogenesis. Dig Liver Dis. 41:665–670. 2009. View Article : Google Scholar : PubMed/NCBI

72 

Ma WL, Hsu CL, Wu MH, Wu CT, Wu CC, Lai JJ, Jou YS, Chen CW, Yeh S and Chang C: Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma. Gastroenterology. 135:947–955, 955.e1-5. 2008. View Article : Google Scholar : PubMed/NCBI

73 

Yang WJ, Chang CJ, Yeh SH, Lin WH, Wang SH, Tsai TF, Chen DS and Chen PJ: Hepatitis B virus X protein enhances the transcriptional activity of the androgen receptor through c-Src and glycogen synthase kinase-3beta kinase pathways. Hepatology. 49:1515–1524. 2009. View Article : Google Scholar : PubMed/NCBI

74 

Feng H, Cheng AS, Tsang DP, Li MS, Go MY, Cheung YS, Zhao GJ, Ng SS, Lin MC, Yu J, et al: Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives β-catenin/T cell factor-dependent hepatocarcinogenesis. J Clin Invest. 121:3159–3175. 2011. View Article : Google Scholar : PubMed/NCBI

75 

Koh WP, Yuan JM, Wang R, Govindarajan S, Oppenheimer R, Zhang ZQ, Yu MC and Ingles SA: Aromatase (CYP19) promoter gene polymorphism and risk of nonviral hepatitis-related hepatocellular carcinoma. Cancer. 117:3383–3392. 2011. View Article : Google Scholar : PubMed/NCBI

76 

Castagnetta LA, Agostara B, Montalto G, Polito L, Campisi I, Saetta A, Itoh T, Yu B, Chen S and Carruba G: Local estrogen formation by nontumoral, cirrhotic, and malignant human liver tissues and cells. Cancer Res. 63:5041–5045. 2003.PubMed/NCBI

77 

Zhang S, Shu R, Yue M and Zhang S: Effect of over-expression of zinc-finger protein (ZFX) on self-renewal and drug-resistance of hepatocellular carcinoma. Med Sci Monit. 22:3025–3034. 2016. View Article : Google Scholar : PubMed/NCBI

78 

Park SJ, Jeong SY and Kim HJ: Y chromosome loss and other genomic alterations in hepatocellular carcinoma cell lines analyzed by CGH and CGH array. Cancer Genet Cytogenet. 166:56–64. 2006. View Article : Google Scholar : PubMed/NCBI

79 

Liu J, Wang ZM, Zhen SF, Wu XP, Ma DX, Li ZH, Liu B, Zhao ZL and Ke Y: Aberration of X chromosome in liver neoplasm detected by fluorescence in situ hybridization. Hepatobiliary Pancreat Dis Int. 3:110–114. 2004.PubMed/NCBI

80 

Lalli E and Alonso J: Targeting DAX-1 in embryonic stem cells and cancer. Expert Opin Ther Targets. 14:169–177. 2010. View Article : Google Scholar : PubMed/NCBI

81 

Li H, Zhang Z, Bi Y, Yang D, Zhang L and Liu J: Expression characteristics of β-catenin in scallop Chlamys farreri gonads and its role as a potential upstream gene of Dax1 through canonical Wnt signalling pathway regulating the spermatogenesis. PLoS One. 9:e1159172014. View Article : Google Scholar : PubMed/NCBI

82 

Campbell DEK and Langlois VS: Expression of sf1 and dax-1 are regulated by thyroid hormones and androgens during Silurana tropicalis early development. Gen Comp Endocrinol. 259:34–44. 2018. View Article : Google Scholar : PubMed/NCBI

83 

Tsuei DJ, Lee PH, Peng HY, Lu HL, Su DS, Jeng YM, Hsu HC, Hsu SH, Wu JF, Ni YH and Chang MH: Male germ cell-specific RNA binding protein RBMY: A new oncogene explaining male predominance in liver cancer. PLoS One. 6:e269482011. View Article : Google Scholar : PubMed/NCBI

84 

Yin YH, Li YY, Qiao H, Wang HC, Yang XA, Zhang HG, Pang XW, Zhang Y and Chen WF: TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma. Br J Cancer. 93:458–463. 2005. View Article : Google Scholar : PubMed/NCBI

85 

Murakami S, Chishima S, Uemoto H, Sakamoto E, Sato T, Kurabe N, Kawasaki Y, Shibata T, Akiyama H and Tashiro F: The male-specific factor Sry harbors an oncogenic function. Oncogene. 33:2978–2986. 2014. View Article : Google Scholar : PubMed/NCBI

86 

Murakami S, Ninomiya W, Sakamoto E, Shibata T, Akiyama H and Tashiro F: SRY and OCT4 are required for the acquisition of cancer stem cell-like properties and are potential differentiation therapy targets. Stem Cells. 33:2652–2663. 2015. View Article : Google Scholar : PubMed/NCBI

87 

Tsuei DJ, Hsu HC, Lee PH, Jeng YM, Pu YS, Chen CN, Lee YC, Chou WC, Chang CJ, Ni YH and Chang MH: RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts. Oncogene. 23:5815–5822. 2004. View Article : Google Scholar : PubMed/NCBI

88 

Homayounfar K, Schwarz A, Enders C, Cameron S, Baumhoer D, Ramadori G, Lorf T, Gunawan B and Sander B: Etiologic influence on chromosomal aberrations in European hepatocellular carcinoma identified by CGH. Pathol Res Pract. 209:380–387. 2013. View Article : Google Scholar : PubMed/NCBI

89 

Hashimoto K, Mori N, Tamesa T, Okada T, Kawauchi S, Oga A, Furuya T, Tangoku A, Oka M and Sasaki K: Analysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH. Mod Pathol. 17:617–622. 2004. View Article : Google Scholar : PubMed/NCBI

90 

Takeo S, Arai H, Kusano N, Harada T, Furuya T, Kawauchi S, Oga A, Hirano T, Yoshida T, Okita K and Sasaki K: Examination of oncogene amplification by genomic DNA microarray in hepatocellular carcinomas: Comparison with comparative genomic hybridization analysis. Cancer Genet Cytogenet. 130:127–132. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Y, Xu A, Jia S and Huang J: Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma (Review). Oncol Lett 17: 4222-4228, 2019.
APA
Li, Y., Xu, A., Jia, S., & Huang, J. (2019). Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma (Review). Oncology Letters, 17, 4222-4228. https://doi.org/10.3892/ol.2019.10127
MLA
Li, Y., Xu, A., Jia, S., Huang, J."Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma (Review)". Oncology Letters 17.5 (2019): 4222-4228.
Chicago
Li, Y., Xu, A., Jia, S., Huang, J."Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma (Review)". Oncology Letters 17, no. 5 (2019): 4222-4228. https://doi.org/10.3892/ol.2019.10127
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Xu A, Jia S and Huang J: Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma (Review). Oncol Lett 17: 4222-4228, 2019.
APA
Li, Y., Xu, A., Jia, S., & Huang, J. (2019). Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma (Review). Oncology Letters, 17, 4222-4228. https://doi.org/10.3892/ol.2019.10127
MLA
Li, Y., Xu, A., Jia, S., Huang, J."Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma (Review)". Oncology Letters 17.5 (2019): 4222-4228.
Chicago
Li, Y., Xu, A., Jia, S., Huang, J."Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma (Review)". Oncology Letters 17, no. 5 (2019): 4222-4228. https://doi.org/10.3892/ol.2019.10127
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team