Role of caprin‑1 in carcinogenesis (Review)

  • Authors:
    • Zhuo‑Shun Yang
    • Hong Qing
    • Hui Gui
    • Jie Luo
    • Long‑Jun Dai
    • Bin Wang
  • View Affiliations

  • Published online on: April 30, 2019     https://doi.org/10.3892/ol.2019.10295
  • Pages: 15-21
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Abstract

RNA‑binding proteins serve an essential role in post‑transcriptional gene regulation. Cytoplasmic activation/proliferation‑associated protein-1 (caprin‑1) is an RNA‑binding protein that participates in the regulation of cell cycle control‑associated genes. Caprin‑1 acts alone or in combination with other RNA‑binding proteins, such as RasGAP SH3‑domain‑binding protein 1 and fragile X mental retardation protein. In the tumorigenesis process, caprin‑1 primarily functions by activating cell proliferation and upregulating the expression of immune checkpoint proteins. Through the formation of stress granules, caprin‑1 is also involved in the process by which tumor cells adapt to adverse conditions, which contributes to radiation and chemotherapy resistance. Given its role in various clinical malignancies, caprin‑1 holds the potential to be used as a biomarker and a target for the development of novel therapeutics. The present review describes this newly identified putative oncogenic protein and its possible impact on tumorigenesis.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yang ZS, Qing H, Gui H, Luo J, Dai LJ and Wang B: Role of caprin‑1 in carcinogenesis (Review). Oncol Lett 18: 15-21, 2019
APA
Yang, Z., Qing, H., Gui, H., Luo, J., Dai, L., & Wang, B. (2019). Role of caprin‑1 in carcinogenesis (Review). Oncology Letters, 18, 15-21. https://doi.org/10.3892/ol.2019.10295
MLA
Yang, Z., Qing, H., Gui, H., Luo, J., Dai, L., Wang, B."Role of caprin‑1 in carcinogenesis (Review)". Oncology Letters 18.1 (2019): 15-21.
Chicago
Yang, Z., Qing, H., Gui, H., Luo, J., Dai, L., Wang, B."Role of caprin‑1 in carcinogenesis (Review)". Oncology Letters 18, no. 1 (2019): 15-21. https://doi.org/10.3892/ol.2019.10295