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Review

Role of caprin‑1 in carcinogenesis (Review)

  • Authors:
    • Zhuo‑Shun Yang
    • Hong Qing
    • Hui Gui
    • Jie Luo
    • Long‑Jun Dai
    • Bin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, School of Life Science, Beijing Institute of Technology, Beijing 100081, P.R. China
  • Pages: 15-21
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    Published online on: April 30, 2019
       https://doi.org/10.3892/ol.2019.10295
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Abstract

RNA‑binding proteins serve an essential role in post‑transcriptional gene regulation. Cytoplasmic activation/proliferation‑associated protein-1 (caprin‑1) is an RNA‑binding protein that participates in the regulation of cell cycle control‑associated genes. Caprin‑1 acts alone or in combination with other RNA‑binding proteins, such as RasGAP SH3‑domain‑binding protein 1 and fragile X mental retardation protein. In the tumorigenesis process, caprin‑1 primarily functions by activating cell proliferation and upregulating the expression of immune checkpoint proteins. Through the formation of stress granules, caprin‑1 is also involved in the process by which tumor cells adapt to adverse conditions, which contributes to radiation and chemotherapy resistance. Given its role in various clinical malignancies, caprin‑1 holds the potential to be used as a biomarker and a target for the development of novel therapeutics. The present review describes this newly identified putative oncogenic protein and its possible impact on tumorigenesis.
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1 

Gerstberger S, Hafner M and Tuschl T: A census of human RNA-binding proteins. Nat Rev Genet. 15:829–845. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Gerstberger S, Hafner M, Ascano M and Tuschl T: Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease. Adv Exp Med Biol. 825:1–55. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Mori T, Ngouv H, Hayashida M, Akutsu T and Nacher JC: ncRNA-disease association prediction based on sequence information and tripartite network. BMC Syst Biol. 12 (Suppl 1):S372018. View Article : Google Scholar

4 

Hudson WH and Ortlund EA: The structure, function and evolution of proteins that bind DNA and RNA. Nat Rev Mol Cell Biol. 15:749–760. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Keene JD: RNA regulons: Coordination of post-transcriptional events. Nat Rev Genet. 8:533–543. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Nishida K, Kuwano Y, Nishikawa T, Masuda K and Rokutan K: RNA binding proteins and genome integrity. Int J Mol Sci. 18:E13412017. View Article : Google Scholar : PubMed/NCBI

7 

Kai M: Roles of RNA-binding proteins in DNA damage response. Int J Mol Sci. 17:3102016. View Article : Google Scholar : PubMed/NCBI

8 

Harvey R, Dezi V, Pizzinga M and Willis AE: Post-transcriptional control of gene expression following stress: The role of RNA-binding proteins. Biochem Soc Trans. 45:1007–1014. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Sheinberger J and Shav-Tal Y: mRNPs meet stress granules. FEBS Lett. 591:2534–2542. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Maziuk B, Balance HI and Wolozin B: Dysregulation of RNA binding protein aggregation in neurodegenerative disorders. Front Mol Neurosci. 10:892017. View Article : Google Scholar : PubMed/NCBI

11 

Geuens T, Bouhy D and Timmerman V: The hnRNP family: Insights into their role in health and disease. Hum Genet. 135:851–867. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Wurth L and Gebauer F: RNA-binding proteins, multifaceted translational regulators in cancer. Biochim Biophys Acta. 1849:881–886. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Pereira B, Billaud M and Almeida R: RNA-binding proteins in cancer: Old players and new actors. Trends Cancer. 3:506–528. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Paronetto MP, Cappellari M, Busa R, Pedrotti S, Vitali R, Comstock C, Hyslop T, Knudsen KE and Sette C: Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68. Cancer Res. 70:229–239. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Hsieh AC and Ruggero D: Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer. Clin Cancer Res. 16:4914–4920. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Abdelmohsen K and Gorospe M: Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA. 1:214–229. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Wang B, David MD and Schrader JW: Absence of caprin-1 results in defects in cellular proliferation. J Immunol. 175:4274–4282. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Solomon S, Xu Y, Wang B, David MD, Schubert P, Kennedy D and Schrader JW: Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs. Mol Cell Biol. 27:2324–2342. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Reich J and Papoulas O: Caprin controls follicle stem cell fate in the Drosophila ovary. PLoS One. 7:e353652012. View Article : Google Scholar : PubMed/NCBI

20 

Qiu YQ, Yang CW, Lee YZ, Yang RB, Lee CH, Hsu HY, Chang CC and Lee SJ: Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: An identification of a novel oncotarget. Oncotarget. 6:2148–2163. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Grill B, Wilson GM, Zhang KX, Wang B, Doyonnas R, Quadroni M and Schrader JW: Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: Prototype of a new family of proteins. J Immunol. 172:2389–2400. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Gong B, Hu H, Chen J, Cao S, Yu J, Xue J, Chen F, Cai Y, He H and Zhang L: Caprin-1 is a novel microRNA-223 target for regulating the proliferation and invasion of human breast cancer cells. Biomed Pharmacother. 67:629–636. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Sabile AA, Arlt MJ, Muff R, Husmann K, Hess D, Bertz J, Langsam B, Aemisegger C, Ziegler U, Born W and Fuchs B: Caprin-1, a novel Cyr61-interacting protein, promotes osteosarcoma tumor growth and lung metastasis in mice. Biochim Biophys Acta. 1832:1173–1182. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Xiao H, Zeng J, Li H, Chen K, Yu G, Hu J, Tang K, Zhou H, Huang Q, Li A, et al: MiR-1 downregulation correlates with poor survival in clear cell renal cell carcinoma where it interferes with cell cycle regulation and metastasis. Oncotarget. 6:13201–13215. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Teng Y, Ren Y, Hu X, Mu J, Samykutty A, Zhuang X, Deng Z, Kumar A, Zhang L, Merchant ML, et al: MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Nat Commun. 8:144482017. View Article : Google Scholar : PubMed/NCBI

26 

Matsumura I, Tanaka H and Kanakura Y: E2F1 and c-Myc in cell growth and death. Cell Cycle. 2:333–338. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Pardee AB: G1 events and regulation of cell proliferation. Science. 246:603–608. 1989. View Article : Google Scholar : PubMed/NCBI

28 

Zhang L, Gui H, Tang XJ, Yang ZS, Zou DD, Lu JT, Yan LD, Dai LJ, Luo J and Wang B: Expression and tumor-Promoting effects of caprin-1 in human glioma. Glioma. 1:136–141. 2018. View Article : Google Scholar

29 

Casey SC, Tong L, Li Y, Do R, Walz S, Fitzgerald KN, Gouw AM, Baylot V, Gütgemann I, Eilers M and Felsher DW: MYC regulates the antitumor immune response through CD47 and PD-L1. Science. 352:227–231. 2016. View Article : Google Scholar : PubMed/NCBI

30 

El Fatimy R, Tremblay S, Dury AY, Solomon S, De Koninck P, Schrader JW and Khandjian EW: Fragile X mental retardation protein interacts with the RNA-binding protein caprin1 in neuronal ribonucleoprotein complexes [corrected]. PLoS One. 7:e393382012. View Article : Google Scholar : PubMed/NCBI

31 

Katoh H, Okamoto T, Fukuhara T, Kambara H, Morita E, Mori Y, Kamitani W and Matsuura Y: Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation. J Virol. 87:489–502. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K and Warren ST: Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat Neurosci. 7:113–117. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Wu Y, Zhu J, Huang X and Du Z: Crystal structure of a dimerization domain of human Caprin-1: Insights into the assembly of an evolutionarily conserved ribonucleoprotein complex consisting of Caprin-1, FMRP and G3BP1. Acta Crystallogr D Struct Biol. 72:718–727. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Mingle LA, Okuhama NN, Shi J, Singer RH, Condeelis J and Liu G: Localization of all seven messenger RNAs for the actin-polymerization nucleator Arp2/3 complex in the protrusions of fibroblasts. J Cell Sci. 118:2425–2433. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Carson JH and Barbarese E: Systems analysis of RNA trafficking in neural cells. Biol Cell. 97:51–62. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Copsey AC, Cooper S, Parker R, Lineham E, Lapworth C, Jallad D, Sweet S and Morley SJ: The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading. Biochem J. 474:3109–3120. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Thomas MG, Loschi M, Desbats MA and Boccaccio GL: RNA granules: The good, the bad and the ugly. Cell Signal. 23:324–334. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Kedersha N, Ivanov P and Anderson P: Stress granules and cell signaling: More than just a passing phase? Trends Biochem Sci. 38:494–506. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Gilks N, Kedersha N, Ayodele M, Shen L, Stoecklin G, Dember LM and Anderson P: Stress granule assembly is mediated by prion-like aggregation of TIA-1. Mol Biol Cell. 15:5383–5398. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Tourriere H, Chebli K, Zekri L, Courselaud B, Blanchard JM, Bertrand E and Tazi J: The RasGAP-associated endoribonuclease G3BP assembles stress granules. J Cell Biol. 160:823–831. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Kedersha N, Cho MR, Li W, Yacono PW, Chen S, Gilks N, Golan DE and Anderson P: Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules. J Cell Biol. 151:1257–1268. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Mazroui R, Huot ME, Tremblay S, Filion C, Labelle Y and Khandjian EW: Trapping of messenger RNA by fragile X mental retardation protein into cytoplasmic granules induces translation repression. Hum Mol Genet. 11:3007–3017. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WF, Blackwell TK and Anderson P: MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J. 23:1313–1324. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Buchan JR and Parker R: Eukaryotic stress granules: The ins and outs of translation. Mol Cell. 36:932–941. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Gupta N, Badeaux M, Liu Y, Naxerova K, Sgroi D, Munn LL, Jain RK and Garkavtsev I: Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proc Natl Acad Sci USA. 114:1033–1038. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Anderson P, Kedersha N and Ivanov P: Stress granules, P-bodies and cancer. Biochim Biophys Acta. 1849:861–870. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Adjibade P, St-Sauveur VG, Quevillon Huberdeau M, Fournier MJ, Savard A, Coudert L, Khandjian EW and Mazroui R: Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells. Oncotarget. 6:43927–43943. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Vilas-Boas Fde A, da Silva AM, de Sousa LP, Lima KM, Vago JP, Bittencourt LF, Dantas AE, Gomes DA, Vilela MC, Teixeira MM and Barcelos LS: Impairment of stress granule assembly via inhibition of the eIF2alpha phosphorylation sensitizes glioma cells to chemotherapeutic agents. J Neurooncol. 127:253–260. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Somasekharan SP, El-Naggar A, Leprivier G, Cheng H, Hajee S, Grunewald TG, Zhang F, Ng T, Delattre O, Evdokimova V, et al: YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1. J Cell Biol. 208:913–929. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Leprivier G, Rotblat B, Khan D, Jan E and Sorensen PH: Stress-mediated translational control in cancer cells. Biochim Biophys Acta. 1849:845–860. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Szaflarski W, Fay MM, Kedersha N, Zabel M, Anderson P and Ivanov P: Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation. Oncotarget. 7:30307–30322. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Fournier MJ, Coudert L, Mellaoui S, Adjibade P, Gareau C, Côté MF, Sonenberg N, Gaudreault RC and Mazroui R: Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation. Mol Cell Biol. 33:2285–2301. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Tan N, Dai L, Liu X, Pan G, Chen H, Huang J and Xu Q: Upregulation of caprin1 expression is associated with poor prognosis in hepatocellular carcinoma. Pathol Res Pract. 213:1563–1567. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Campanile C, Arlt MJ, Kramer SD, Honer M, Gvozdenovic A, Brennecke P, Fischer CR, Sabile AA, Müller A, Ametamey SM, et al: Characterization of different osteosarcoma phenotypes by PET imaging in preclinical animal models. J Nucl Med. 54:1362–1368. 2013. View Article : Google Scholar : PubMed/NCBI

55 

Kedracka-Krok S, Jankowska U, Elas M, Sowa U, Swakon J, Cierniak A, Olko P, Romanowska-Dixon B and Urbanska K: Proteomic analysis of proton beam irradiated human melanoma cells. PLoS One. 9:e846212014. View Article : Google Scholar : PubMed/NCBI

56 

Min L, Ruan Y, Shen Z, Jia D, Wang X, Zhao J, Sun Y and Gu J: Overexpression of Ras-GTPase-activating protein SH3 domain-binding protein 1 correlates with poor prognosis in gastric cancer patients. Histopathology. 67:677–688. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Zhang H, Zhang SH, He HW, Zhang CX, Yu DK and Shao RG: Downregulation of G3BPs inhibits the growth, migration and invasion of human lung carcinoma H1299 cells by suppressing the Src/FAK-associated signaling pathway. Cancer Gene Ther. 20:622–629. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Taniuchi K, Nishimori I and Hollingsworth MA: The N-terminal domain of G3BP enhances cell motility and invasion by posttranscriptional regulation of BART. Mol Cancer Res. 9:856–866. 2011. View Article : Google Scholar : PubMed/NCBI

59 

Zhang H, Zhang S, He H, Zhao W, Chen J and Shao RG: GAP161 targets and downregulates G3BP to suppress cell growth and potentiate cisplaitin-mediated cytotoxicity to colon carcinoma HCT116 cells. Cancer Sci. 103:1848–1856. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang ZS, Qing H, Gui H, Luo J, Dai LJ and Wang B: Role of caprin‑1 in carcinogenesis (Review). Oncol Lett 18: 15-21, 2019.
APA
Yang, Z., Qing, H., Gui, H., Luo, J., Dai, L., & Wang, B. (2019). Role of caprin‑1 in carcinogenesis (Review). Oncology Letters, 18, 15-21. https://doi.org/10.3892/ol.2019.10295
MLA
Yang, Z., Qing, H., Gui, H., Luo, J., Dai, L., Wang, B."Role of caprin‑1 in carcinogenesis (Review)". Oncology Letters 18.1 (2019): 15-21.
Chicago
Yang, Z., Qing, H., Gui, H., Luo, J., Dai, L., Wang, B."Role of caprin‑1 in carcinogenesis (Review)". Oncology Letters 18, no. 1 (2019): 15-21. https://doi.org/10.3892/ol.2019.10295
Copy and paste a formatted citation
x
Spandidos Publications style
Yang ZS, Qing H, Gui H, Luo J, Dai LJ and Wang B: Role of caprin‑1 in carcinogenesis (Review). Oncol Lett 18: 15-21, 2019.
APA
Yang, Z., Qing, H., Gui, H., Luo, J., Dai, L., & Wang, B. (2019). Role of caprin‑1 in carcinogenesis (Review). Oncology Letters, 18, 15-21. https://doi.org/10.3892/ol.2019.10295
MLA
Yang, Z., Qing, H., Gui, H., Luo, J., Dai, L., Wang, B."Role of caprin‑1 in carcinogenesis (Review)". Oncology Letters 18.1 (2019): 15-21.
Chicago
Yang, Z., Qing, H., Gui, H., Luo, J., Dai, L., Wang, B."Role of caprin‑1 in carcinogenesis (Review)". Oncology Letters 18, no. 1 (2019): 15-21. https://doi.org/10.3892/ol.2019.10295
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