Open Access

Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma

  • Authors:
    • Nana Zhang
    • Hong Wang
    • Qiqi Xie
    • Hua Cao
    • Fanqi Wu
    • Dan Bei Di Wu
    • Yixin Wan
  • View Affiliations

  • Published online on: May 2, 2019     https://doi.org/10.3892/ol.2019.10300
  • Pages: 169-180
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The purpose of this study was to identify potential molecular markers of lung squamous cell carcinoma (LUSC). Three datasets containing LUSC mRNA sequencing data were downloaded from the Gene Expression Omnibus, The Cancer Genome Atlas and the Gene Expression Profiling Interactive Analysis databases. These datasets were used to identify significantly differentially expressed genes (DEGs) in LUSC. A protein‑protein interaction network of the DEGs was constructed followed by Gene Ontology, Kyoto Encyclopedia of Genes and Genomes and overall survival analyses of the DEGs. A total of 37 DEGs between LUSC and normal tissues were identified, including 26 downregulated genes and 11 upregulated genes. Biological Process enrichment analysis revealed that the DEGs were mainly enriched in ‘cell adhesion’, ‘cell‑matrix adhesion’, ‘anatomical structure morphogenesis’, ‘ECM‑receptor interaction’ and ‘focal adhesion’. Overall survival analysis demonstrated that transcription factor 21, α‑2‑macroglobulin, acyl‑CoA synthetase long chain family member 5, integrin subunit β8, meiotic nuclear divisions 1 and secretoglobin family 1A member 1 were significantly associated with the occurrence and development of lung cancer, and these genes were selected as hub genes. The results obtained in the present study may aid the elucidation of the molecular mechanisms involved in the development of LUSC and may provide potential targets for LUSC treatment.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang N, Wang H, Xie Q, Cao H, Wu F, Di Wu D and Wan Y: Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma. Oncol Lett 18: 169-180, 2019
APA
Zhang, N., Wang, H., Xie, Q., Cao, H., Wu, F., Di Wu, D., & Wan, Y. (2019). Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma. Oncology Letters, 18, 169-180. https://doi.org/10.3892/ol.2019.10300
MLA
Zhang, N., Wang, H., Xie, Q., Cao, H., Wu, F., Di Wu, D., Wan, Y."Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma". Oncology Letters 18.1 (2019): 169-180.
Chicago
Zhang, N., Wang, H., Xie, Q., Cao, H., Wu, F., Di Wu, D., Wan, Y."Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma". Oncology Letters 18, no. 1 (2019): 169-180. https://doi.org/10.3892/ol.2019.10300