Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma

  • Authors:
    • Nana Zhang
    • Hong Wang
    • Qiqi Xie
    • Hua Cao
    • Fanqi Wu
    • Dan Bei Di Wu
    • Yixin Wan
  • View Affiliations / Copyright

    Affiliations: Department of Respiration, Second Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 169-180
    |
    Published online on: May 2, 2019
       https://doi.org/10.3892/ol.2019.10300
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The purpose of this study was to identify potential molecular markers of lung squamous cell carcinoma (LUSC). Three datasets containing LUSC mRNA sequencing data were downloaded from the Gene Expression Omnibus, The Cancer Genome Atlas and the Gene Expression Profiling Interactive Analysis databases. These datasets were used to identify significantly differentially expressed genes (DEGs) in LUSC. A protein‑protein interaction network of the DEGs was constructed followed by Gene Ontology, Kyoto Encyclopedia of Genes and Genomes and overall survival analyses of the DEGs. A total of 37 DEGs between LUSC and normal tissues were identified, including 26 downregulated genes and 11 upregulated genes. Biological Process enrichment analysis revealed that the DEGs were mainly enriched in ‘cell adhesion’, ‘cell‑matrix adhesion’, ‘anatomical structure morphogenesis’, ‘ECM‑receptor interaction’ and ‘focal adhesion’. Overall survival analysis demonstrated that transcription factor 21, α‑2‑macroglobulin, acyl‑CoA synthetase long chain family member 5, integrin subunit β8, meiotic nuclear divisions 1 and secretoglobin family 1A member 1 were significantly associated with the occurrence and development of lung cancer, and these genes were selected as hub genes. The results obtained in the present study may aid the elucidation of the molecular mechanisms involved in the development of LUSC and may provide potential targets for LUSC treatment.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Gandara DR, Hammerman PS, Sos ML, Lara PN Jr and Hirsch FR: Squamous cell lung cancer: From tumor genomics to cancer therapeutics. Clin Cancer Res. 21:2236–2243. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Perezmoreno P, Brambilla E, Thomas R and Soria JC: Squamous cell carcinoma of the lung: Molecular subtypes and therapeutic opportunities. Clin Cancer Res. 18:2443–2451. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Kuribayashi K, Funaguchi N and Nakano T: Chemotherapy for advanced non-small cell lung cancer with a focus on squamous cell carcinoma. J Cancer Res Ther. 12:528–534. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Morrey ME, Abdel MP, Riester SM, Dudakovic A, van Wijnen AJ, Morrey BF and Sanchez-Sotelo J: Molecular landscape of arthrofibrosis: Microarray and bioinformatic analysis of the temporal expression of 380 genes during contracture genesis. Gene. 610:15–23. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Liu C, Fei HD, Sun ZY and Tian JW: Bioinformatic analysis of the microarray gene expression profile in degenerative intervertebral disc cells exposed to TNF-α. Eur Rev Med Pharmacol Sci. 19:3332–3339. 2015.PubMed/NCBI

7 

Meltzer EB, Barry WT, D'Amico TA, Davis RD, Shu SL, Onaitis MW, Morrison LD, Sporn TA, Steele MP and Noble PW: Bayesian probit regression model for the diagnosis of pulmonary fibrosis: Proof-of-principle. BMC Med Genomics. 4:702011. View Article : Google Scholar : PubMed/NCBI

8 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res 39 (Database Issue). D991–D1005. 2013.

9 

Tomczak K, Czerwińska P and Wiznerowicz M: The cancer genome atlas (TCGA): An immeasurable source of knowledge. Contemp Oncol (Pozn). 19:A68–A77. 2015.PubMed/NCBI

10 

Lin J, Marquardt G, Mullapudi N, Wang T, Han W, Shi M, Keller S, Zhu C, Locker J and Spivack SD: Lung cancer transcriptomes refined with laser capture microdissection. Am J Pathol. 184:2868–2884. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Li JR, Sun CH, Li W, Chao RF, Huang CC, Zhou XJ and Liu CC: Cancer RNA-Seq Nexus: A database of phenotype-specific transcriptome profiling in cancer cells. Nucleic Acids Res. 44(D1): D944–D951. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Core Team R: R: A language and environment for statistical computing. Computing. 1:12–21. 2015.

13 

Troyanskaya O, Cantor M, Sherlock G, Brown P, Hastie T, Tibshirani R, Botstein D and Altman RB: Missing value estimation methods for DNA microarrays. Bioinformatics. 17:520–525. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Hogan SJ, Feltz KT, Murdock DR, Goodman TA, Vercande DJ, Tangeman MR, Busch EM, Kripakaran R, Jayasimha MG, Smith KE, et al: Call-processing system and method. 2003.

15 

Pathan M, Keerthikumar S, Ang CS, Gangoda L, Quek CY, Williamson NA, Mouradov D, Sieber OM, Simpson RJ, Salim A, et al: FunRich: An open access standalone functional enrichment and interaction network analysis tool. Proteomics. 15:2597–2601. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, Franz M, Grouios C, Kazi F, Lopes CT, et al: The GeneMANIA prediction server: Biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res 38 (Web Server Issue). W214–W220. 2010. View Article : Google Scholar

17 

Goldman M, Craft B, Zhu J and Haussler D: Abstract 2584: The UCSC Xena system for cancer genomics data visualization and interpretation. Cancer Res. 77:25842017.

18 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Ogata H, Goto S, Sato K, Fujibuchi W, Bono H and Kanehisa M: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 27:29–34. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Huang DW, Sherman BT, Tan Q, Collins JR, Alvord WG, Roayaei J, Stephens R, Baseler MW, Lane HC and Lempicki RA: The DAVID gene functional classification tool: A novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol. 8:R1832007. View Article : Google Scholar : PubMed/NCBI

21 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res 45 (W1). W98–W102. 2017. View Article : Google Scholar

22 

Piao J, Sun J, Yang Y, Jin T, Chen L and Lin Z: Target gene screening and evaluation of prognostic values in non-small cell lung cancers by bioinformatics analysis. Gene. 647:306–311. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Mitteer DR, Greer BD, Fisher WW and Cohrs VL: Teaching behavior technicians to create publication-quality, single-case design graphs in graphpad prism 7. J Appl Behav Anal. 51:998–1010. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Pontén F, Jirström K and Uhlen M: The human protein atlas-a tool for pathology. J Pathol. 216:387–393. 2010. View Article : Google Scholar

25 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Beer DG, Kardia SL, Huang CC, Giordano TJ, Levin AM, Misek DE, Lin L, Chen G, Gharib TG, Thomas DG, et al: Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med. 8:816–824. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Non-Small Cell Lung Cancer Collaborative Group, . Chemotherapy and supportive care versus supportive care alone for advanced non-small cell lung cancer. Cochrane Database Syst Rev. 12:CD0073092010.

28 

Blandin KS, Crosbie PA, Balata H, Chudziak J, Hussell T and Dive C: Progress and prospects of early detection in lung cancer. Open Biol. 7(pii): 1700702017. View Article : Google Scholar : PubMed/NCBI

29 

Mayekar MK and Bivona TG: Current landscape of targeted therapy in lung cancer. Clin Pharmacol Ther. 102:757–764. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Jamal-Hanjani M, Wilson GA, McGranahan N, Birkbak NJ, Watkins TBK, Veeriah S, Shafi S, Johnson DH, Mitter R, Rosenthal R, et al: Tracking the evolution of non-small-cell lung cancer. N Engl J Med. 376:2109–2121. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Youlden DR, Cramb SM and Baade PD: The international epidemiology of lung cancer: Geographical distribution and secular trends. J Thorac Oncol. 3:819–831. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Cheng TY, Cramb SM, Baade PD, Youlden DR, Nwogu C and Reid ME: The international epidemiology of lung cancer: Latest trends, disparities, and tumor characteristics. J Thorac Oncol. 11:1653–1671. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Raghavachari N: Microarray technology: Basic methodology and application in clinical research for biomarker discovery in vascular diseases. Methods Mol Biol. 1027:47–84. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Li G, Li X, Yang M, Xu L, Deng S and Ran L: Prediction of biomarkers of oral squamous cell carcinoma using microarray technology. Sci Rep. 7:421052017. View Article : Google Scholar : PubMed/NCBI

35 

Albelda SM and Buck CA: Integrins and other cell adhesion molecules. FASEB J. 4:2868–2880. 1990. View Article : Google Scholar : PubMed/NCBI

36 

Zaman MH, Trapani LM, Siemeski A, Mackellar D, Gong H, Kamm RD, Wells A, Lauffenburger DA and Matsudaira P: Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc Natl Acad Sci USA. 103:10889–10894. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Uccelli A, Moretta L and Pistoia V: Mesenchymal stem cells in health and disease. Nat Rev Immunol. 8:726–736. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Wang D, Song Z and Wang Z: Common mechanism of pathogenesis in various types of metastatic osteosarcoma. Oncol Lett. 14:6307–6313. 2017.PubMed/NCBI

39 

Laval S, Laklai H, FanJul M, Pucelle M, Susini C, Pyronnet S and Bousquet C: Abstract 5181: Forced hemidesmosome assembly blocks pancreatic cancer cell invasiveness. Cancer Res. 70:51812011.

40 

Zamanian-Daryoush M and DiDonato JA: Apolipoprotein A-I and cancer. Front Pharmacol. 6:2652015. View Article : Google Scholar : PubMed/NCBI

41 

Zhang H, Tao J, Sheng L, Hu X, Rong R, Xu M and Zhu T: RETRACTED: Twist2 promotes kidney cancer cell proliferation and invasion via regulating ITGA6 and CD44 expression in the ECM-Receptor-Interaction pathway. Biomed Biomed Pharmacother. 81:453–459. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Golubovskaya VM: Focal adhesion kinase as a cancer therapy target. Anticancer Agents Med Chem. 10:735–741. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Randell SH: Airway epithelial stem cells and the pathophysiology of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 3:718–725. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Giangreco A, Reynolds SD and Stripp BR: Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. Am J Pathol. 161:173–182. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Antico G, Lingen MW, Sassano A, Melby J, Welch RW, Fiore S, Pilon AL and Miele L: Recombinant human uteroglobin/CC10 inhibits the adhesion and migration of primary human endothelial cells via specific and saturable binding to fibronectin. J Cell Physiol. 207:553–561. 2010. View Article : Google Scholar

46 

Singh G and Katyal SL: Clara cell proteins. Ann N Y Acad Sci. 923:43–58. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Yang Y, Zhang Z, Mukherjee AB and Linnoila RI: Increased susceptibility of mice lacking Clara cell 10-kDa protein to lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke. J Biol Chem. 279:29336–29340. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Wang SZ, Rosenberger CL, Bao YX, Stark JM and Harrod KS: Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection. J Immunol. 171:1051–1060. 2003. View Article : Google Scholar : PubMed/NCBI

49 

Watson TM, Reynolds SD, Mango GW, Boe IM, Lund J and Stripp BR: Altered lung gene expression in CCSP-null mice suggests immunoregulatory roles for Clara cells. Am J Physiol Lung Cell Mol Physiol. 281:L1523–L1530. 2001. View Article : Google Scholar : PubMed/NCBI

50 

Laucho-Contreras ME, Polverino F, Tesfaigzi Y, Pilon A, Celli BR and Owen CA: Club cell protein 16 (CC16) augmentation: A potential disease-modifying approach for chronic obstructive pulmonary disease (COPD). Expert Opin Ther Targets. 20:869–883. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Ludovini V, Bianconi F, Siggillino A, Piobbico D, Vannucci J, Metro G, Chiari R, Bellezza G, Puma F, Della Fazia MA, et al: Gene identification for risk of relapse in stage I lung adenocarcinoma patients: A combined methodology of gene expression profiling and computational gene network analysis. Oncotarget. 7:30561–30574. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Linnoila RI, Szabo E, DeMayo F, Witschi H, Sabourin C and Malkinson A: The role of CC10 in pulmonary carcinogenesis: From a marker to tumor suppression. Ann N Y Acad Sci. 923:249–267. 2000. View Article : Google Scholar : PubMed/NCBI

53 

Bourdin A, Kotsimbos T, Nguyen K, Vachier I, Mainprice B, Farce M, Paganin F, Marty-Ané C, Vernhet H, Godard P and Chanez P: Non-invasive assessment of small airway remodelling in smokers. COPD. 7:102–110. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Sun Y, Yin X, Wen MM, Zhang J, Wang XJ, Xia JH, Zhang YN, Zhang ZP and Li XF: EGFR mutations subset in Chinese lung squamous cell carcinoma patients. Mol Med Rep. 17:7575–7584. 2018.PubMed/NCBI

55 

Thakur C, Rapp UR and Rudel T: Cysts mark the early stage of metastatic tumor development in non-small cell lung cancer. Oncotarget. 9:6518–6535. 2017.PubMed/NCBI

56 

Robb L, Mifsud L, Hartley L, Biben C, Copeland NG, Gilbert DJ, Jenkins NA and Harvey RP: Epicardin: A novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads. Dev Dyn. 213:105–113. 1998. View Article : Google Scholar : PubMed/NCBI

57 

Smith LT, Lin M, Brena RM, Lang JC, Schuller DE, Otterson GA, Morrison CD, Smiraglia DJ and Plass C: Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer. Proc Natl Acad Sci USA. 103:982–987. 2006. View Article : Google Scholar : PubMed/NCBI

58 

Arab K, Smith LT, Gast A, Weichenhan D, Huang JP, Claus R, Hielscher T, Espinosa AV, Ringel MD, Morrison CD, et al: Epigenetic deregulation of TCF21 inhibits metastasis suppressor KISS1 in metastatic melanoma. Carcinogenesis. 32:1467–1473. 2011. View Article : Google Scholar : PubMed/NCBI

59 

Costa VL, Henrique R, Danielsen SA, Eknaes M, Patrício P, Morais A, Oliveira J, Lothe RA, Teixeira MR, Lind GE and Jerónimo C: TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers. Epigenetics. 6:1120–1130. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Richards KL, Zhang B, Sun M, Dong W, Churchill J, Bachinski LL, Wilson CD, Baggerly KA, Yin G, Hayes DN, et al: Methylation of the candidate biomarker TCF21 is very frequent across a spectrum of early-stage nonsmall cell lung cancers. Cancer. 117:606–617. 2011. View Article : Google Scholar : PubMed/NCBI

61 

Chen X, Kong X, Zhang Z, Chen W, Chen J, Li H, Cao W, Ge Y and Fang S: Alpha-2-macroglobulin as a radioprotective agent: A review. Chin J Cancer Res. 26:611–621. 2014.PubMed/NCBI

62 

Kurz S, Thieme R, Amberg R, Groth M, Jahnke HG, Pieroh P, Horn LC, Kolb M, Huse K, Platzer M, et al: Correction: The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat. PLoS One. 13:e01951692018. View Article : Google Scholar : PubMed/NCBI

63 

Birkenmeier G, Müller R, Huse K, Forberg J, Gläser C, Hedrich H, Nicklisch S and Reichenbach A: Human alpha2-macroglobulin: Genotype-phenotype relation. Exp Neurol. 184:153–161. 2003. View Article : Google Scholar : PubMed/NCBI

64 

Klaus C, Kaemmerer E, Reinartz A, Schneider U, Plum P, Jeon MK, Hose J, Hartmann F, Schnölzer M, Wagner N, et al: TP53 status regulates ACSL5-induced expression of mitochondrial mortalin in enterocytes and colorectal adenocarcinomas. Cell Tissue Res. 357:267–278. 2014. View Article : Google Scholar : PubMed/NCBI

65 

Mashima T, Oh-hara T, Sato S, Mochizuki M, Sugimoto Y, Yamazaki K, Hamada J, Tada M, Moriuchi T, Ishikawa Y, et al: p53-defective tumors with a functional apoptosome-mediated pathway: A new therapeutic target. J Natl Cancer Inst. 97:765–777. 2005. View Article : Google Scholar : PubMed/NCBI

66 

Ding S, Tang S, Wang M, Wu D and Guo H: Acyl-CoA synthetase 5 promotes the growth and invasion of colorectal cancer cells. Can J Gastroenterol Hepatol. 2017:76157362017. View Article : Google Scholar : PubMed/NCBI

67 

Pitule P, Vycital O, Bruha J, Novak P, Hosek P, Treska V, Hlavata I, Soucek P, Kralickova M and Liska V: Differential expression and prognostic role of selected genes in colorectal cancer patients. Anticancer Res. 33:4855–4865. 2013.PubMed/NCBI

68 

Ni R, Shen X, Wu H, Zhu W, Ni J, Huang Z, Song Y and Gao X: Expression and significance of integrins subunits in laryngeal squamous cell carcinoma. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 24:686–689. 2010.(In Chinese). PubMed/NCBI

69 

Xu Z and Wu R: Alteration in metastasis potential and gene expression in human lung cancer cell lines by ITGB8 silencing. Anat Rec (Hoboken). 295:1446–1454. 2012. View Article : Google Scholar : PubMed/NCBI

70 

Huang L, Cai JL, Huang PZ, Kang L, Huang MJ, Wang L and Wang JP: miR19b-3p promotes the growth and metastasis of colorectal cancer via directly targeting ITGB8. Am J Cancer Res. 7:1996–2008. 2017.PubMed/NCBI

71 

Tsubouchi H and Roeder GS: The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair. Mol Cell Biol. 22:3078–3088. 2002. View Article : Google Scholar : PubMed/NCBI

72 

Yeganeh PN, Richardson C, Bahrani-Mostafavi Z, Tait DL and Mostafavi MT: Dysregulation of AKT3 along with a small panel of mRNAs stratifies high-grade serous ovarian cancer from both normal epithelia and benign tumor tissues. Genes Cancer. 8:784–798. 2017.PubMed/NCBI

73 

Yang Z and Jiang X, Li D, Dong Q, Zhao H and Jiang X: TCF21 inhibits proliferation and chemoresistance through the AKT pathway in human gastric cancer. Gene. 682:42–49. 2019. View Article : Google Scholar : PubMed/NCBI

74 

Dai Y, Duan H, Duan C, Zhu H, Zhou R, Pei H and Shen L: TCF21 functions as a tumor suppressor in colorectal cancer through inactivation of PI3K/AKT signaling. Onco Targets Ther. 10:1603–1611. 2017. View Article : Google Scholar : PubMed/NCBI

75 

Shijubo N, Itoh Y and Abe S: Anti-inflammatory molecule, Clara cell 10 kilodalton protein and respiratory diseases. Rinsho Byori. 50:370–373. 2002.(In Japanese). PubMed/NCBI

76 

Joyce JA and Fearon DT: T cell exclusion, immune privilege, and the tumor microenvironment. Science. 348:74–80. 2015. View Article : Google Scholar : PubMed/NCBI

77 

Kurz S, Thieme R, Amberg R, Groth M, Jahnke HG, Pieroh P, Horn LC, Kolb M, Huse K, Platzer M, et al: The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat. PLoS One. 12:e01895142017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang N, Wang H, Xie Q, Cao H, Wu F, Di Wu D and Wan Y: Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma. Oncol Lett 18: 169-180, 2019.
APA
Zhang, N., Wang, H., Xie, Q., Cao, H., Wu, F., Di Wu, D., & Wan, Y. (2019). Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma. Oncology Letters, 18, 169-180. https://doi.org/10.3892/ol.2019.10300
MLA
Zhang, N., Wang, H., Xie, Q., Cao, H., Wu, F., Di Wu, D., Wan, Y."Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma". Oncology Letters 18.1 (2019): 169-180.
Chicago
Zhang, N., Wang, H., Xie, Q., Cao, H., Wu, F., Di Wu, D., Wan, Y."Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma". Oncology Letters 18, no. 1 (2019): 169-180. https://doi.org/10.3892/ol.2019.10300
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang N, Wang H, Xie Q, Cao H, Wu F, Di Wu D and Wan Y: Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma. Oncol Lett 18: 169-180, 2019.
APA
Zhang, N., Wang, H., Xie, Q., Cao, H., Wu, F., Di Wu, D., & Wan, Y. (2019). Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma. Oncology Letters, 18, 169-180. https://doi.org/10.3892/ol.2019.10300
MLA
Zhang, N., Wang, H., Xie, Q., Cao, H., Wu, F., Di Wu, D., Wan, Y."Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma". Oncology Letters 18.1 (2019): 169-180.
Chicago
Zhang, N., Wang, H., Xie, Q., Cao, H., Wu, F., Di Wu, D., Wan, Y."Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma". Oncology Letters 18, no. 1 (2019): 169-180. https://doi.org/10.3892/ol.2019.10300
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team