Open Access

Cervical cancer stem cell‑associated genes: Prognostic implications in cervical cancer (Review)

  • Authors:
    • Jorge Organista‑Nava
    • Yazmín Gómez‑Gómez
    • Olga Lilia Garibay‑Cerdenares
    • Marco Antonio Leyva‑Vázquez
    • Berenice Illades‑Aguiar
  • View Affiliations

  • Published online on: May 3, 2019     https://doi.org/10.3892/ol.2019.10307
  • Pages: 7-14
  • Copyright: © Organista‑Nava et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer is the fourth most common type of gynecological malignancy to affect females, worldwide. Although high‑risk human papillomavirus (HR‑HPV) infection is the primary etiologic agent associated with the development of cervical cancer, cancer stem cells (CSCs) also serve a prominent role in the development, metastasis, recurrence and prognosis of the disease. CSCs are a small subpopulation of cells that have the ability to self‑renew and are present in the majority of tumors, including cervical cancer. Studies describing the phenotype of cervical CSCs (CCSCs) vary in their definition of the expression pattern of principal biomarkers, including Musashi‑1, aldehyde dehydrogenase 1, Oct3/4, Sox2 and CD49f. However, these markers are not observed in all cancers, although several may be present in multiple tumor types. The present review describes the potential biomarkers of CSCs in cervical cancer. These CCSC biomarkers may serve as molecular targets to enhance the efficacy and reduce the side effects associated with chemotherapeutic treatment in HR‑HPV‑positive cervical cancer.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Organista‑Nava J, Gómez‑Gómez Y, Garibay‑Cerdenares OL, Leyva‑Vázquez MA and Illades‑Aguiar B: Cervical cancer stem cell‑associated genes: Prognostic implications in cervical cancer (Review). Oncol Lett 18: 7-14, 2019
APA
Organista‑Nava, J., Gómez‑Gómez, Y., Garibay‑Cerdenares, O.L., Leyva‑Vázquez, M.A., & Illades‑Aguiar, B. (2019). Cervical cancer stem cell‑associated genes: Prognostic implications in cervical cancer (Review). Oncology Letters, 18, 7-14. https://doi.org/10.3892/ol.2019.10307
MLA
Organista‑Nava, J., Gómez‑Gómez, Y., Garibay‑Cerdenares, O. L., Leyva‑Vázquez, M. A., Illades‑Aguiar, B."Cervical cancer stem cell‑associated genes: Prognostic implications in cervical cancer (Review)". Oncology Letters 18.1 (2019): 7-14.
Chicago
Organista‑Nava, J., Gómez‑Gómez, Y., Garibay‑Cerdenares, O. L., Leyva‑Vázquez, M. A., Illades‑Aguiar, B."Cervical cancer stem cell‑associated genes: Prognostic implications in cervical cancer (Review)". Oncology Letters 18, no. 1 (2019): 7-14. https://doi.org/10.3892/ol.2019.10307