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Lymphoepithelioma‑like gastric carcinoma treated with partial gastrectomy: Two case reports

  • Authors:
    • Huihua Cao
    • Jun Xie
    • Yongxiang Qian
    • Yugang Wu
    • Zhaoqing Tang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Third Affiliated Hospital of Soochow University and The First People's Hospital of Changzhou, Changzhou, Jiangsu 213000, P.R. China, Department of Pathology, The Third Affiliated Hospital of Soochow University and The First People's Hospital of Changzhou, Changzhou, Jiangsu 213000, P.R. China, Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University and The First People's Hospital of Changzhou, Changzhou, Jiangsu 213000, P.R. China, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
    Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 545-552
    |
    Published online on: May 17, 2019
       https://doi.org/10.3892/ol.2019.10368
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Abstract

Lymphoepithelioma‑like gastric carcinoma (LELGC) is a rare type of gastric cancer characterized by intense lymphocytic infiltration of the stroma. LELGC is associated with Epstein‑Barr virus infection and has a favorable prognosis compared with other types of gastric carcinoma. The clinical symptoms of LELGC are usually similar to those of conventional gastric carcinoma. The diagnosis of LELGC is established based on pathological, histological and immunohistochemical findings. The present report describes the cases of two patients with LELGC who underwent esophagogastroduodenoscopy and computed tomography scans prior to surgery. The two patients accepted surgical treatment, and postoperative pathological and immunohistochemical analyses confirmed LELGC. Neither patient experienced local recurrence or distant metastasis during the postoperative period.
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1 

Chen M, Yin L, Yao Y, Wang L, Xu G, Zhang X, Lv Y, Sun QI, Fan X and Zou X: Lymphoepithelioma-like gastric carcinoma in a patient with rectal laterally spreading tumor: A case report. Oncol Lett. 11:2491–2496. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Watanabe H, Enjoji M and Imai T: Gastric carcinoma with lymphoid stroma. Its morphologic characteristics and prognostic correlations. Cancer. 38:232–243. 1976. View Article : Google Scholar : PubMed/NCBI

3 

Corvalan A, Ding S, Koriyama C, Carrascal E, Carrasquilla G, Backhouse C, Urzua L, Argandona J, Palma M, Eizuru Y and Akiba S: Association of a distinctive strain of Epstein-Barr virus with gastric cancer. Int J Cancer. 118:1736–1742. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Kim SW, Shin HC, Kim IY, Kim CJ, Lee JH, Lee CK and Jeong DJ: Epstein-Barr virus-associated lymphoepithelioma-like gastric carcinoma presenting as a submucosal mass: CT findings with pathologic correlation. Korean J Radiol. 11:697–700. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Xu Q, Du J and Liu BL: Lymphoepithelioma-like gastric carcinoma located in the lesser curvature of the gastric body: A case report and review of the literature. Mol Clin Oncol. 4:405–408. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Grogg KL, Lohse CM, Pankratz VS, Halling KC and Smyrk TC: Lymphocyte-rich gastric cancer: Associations with Epstein-Barr virus, microsatellite instability, histology, and survival. Mod Pathol. 16:641–651. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Weiss LM and Movahed LA: In situ demonstration of Epstein-Barr viral genomes in viral-associated B cell lymphoproliferations. Am J Pathol. 134:651–659. 1989.PubMed/NCBI

8 

Lee JY, Kim KM, Min BH, Lee JH, Rhee PL and Kim JJ: Epstein-Barr virus-associated lymphoepithelioma-like early gastric carcinomas and endoscopic submucosal dissection: Case series. World J Gastroenterol. 20:1365–1370. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Cheng N, Hui DY, Liu Y, Zhang NN, Jiang Y, Han J, Li HG, Ding YG, Du H, Chen JN and Shao CK: Is gastric lymphoepithelioma-like carcinoma a special subtype of EBV-associated gastric carcinoma? New insight based on clinicopathological features and EBV genome polymorphisms. Gastric Cancer. 18:246–255. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Song HJ, Srivastava A, Lee J, Kim YS, Kim KM, Ki Kang W, Kim M and Kim S, Park CK and Kim S: Host inflammatory response predicts survival of patients with Epstein-Barr virus-associated gastric carcinoma. Gastroenterology. 139:84–92.e82. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Shibata D, Tokunaga M, Uemura Y, Sato E, Tanaka S and Weiss LM: Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Lymphoepithelioma-like carcinoma. Am J Pathol. 139:469–474. 1991.PubMed/NCBI

12 

Sousa H, Pinto-Correia AL, Medeiros R and Dinis-Ribeiro M: Epstein-Barr virus is associated with gastric carcinoma: The question is what is the significance? World J Gastroenterol. 14:4347–4351. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Wang ZH, Zhao JJ and Yuan Z: Lymphoepithelioma-like gastric carcinoma: A case report and review of the literature. World J Gastroenterol. 22:3056–3061. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Chang MS, Kim WH, Kim CW and Kim YI: Epstein-Barr virus in gastric carcinomas with lymphoid stroma. Histopathology. 37:309–315. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Kang GH, Lee S, Kim WH, Lee HW, Kim JC, Rhyu MG and Ro JY: Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol. 160:787–794. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Maeda E, Akahane M, Uozaki H, Kato N, Hayashi N, Fukayama M and Ohtomo K: CT appearance of Epstein-Barr virus-associated gastric carcinoma. Abdom Imaging. 34:618–625. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Fukayama M and Ushiku T: Epstein-Barr virus-associated gastric carcinoma. Pathology, Res Pract. 207:529–537. 2011. View Article : Google Scholar

18 

Shinozaki-Ushiku A, Kunita A and Fukayama M: Update on Epstein-Barr virus and gastric cancer (review). Int J Oncol. 46:1421–1434. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Tse E and Kwong YL: Epstein Barr virus-associated lymphoproliferative diseases: The virus as a therapeutic target. Exp Mol Med. 47:e1362015. View Article : Google Scholar : PubMed/NCBI

20 

Geng L and Wang X: Epstein-Barr virus-associated lymphoproliferative disorders: Experimental and clinical developments. Int J Clin Exp Med. 8:14656–14671. 2015.PubMed/NCBI

21 

Tak DH, Jeong HY, Seong JK, Moon HS and Kang SH: Comparison of clinical characteristics and prognostic factors between gastric lymphoepithelioma-like carcinoma and gastric adenocarcinoma. Korean J Gastroenterol. 62:272–277. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Park S, Choi MG, Kim KM, Kim HS, Jung SH, Lee JH, Noh JH, Sohn TS, Bae JM and Kim S: Lymphoepithelioma-like carcinoma: A distinct type of gastric cancer. J Surg Res. 194:458–463. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Nakamura S, Ueki T, Yao T, Ueyama T and Tsuneyoshi M: Epstein-Barr virus in gastric carcinoma with lymphoid stroma. Special reference to its detection by the polymerase chain reaction and in situ hybridization in 99 tumors, including a morphologic analysis. Cancer. 73:2239–2249. 1994. View Article : Google Scholar : PubMed/NCBI

24 

Liu S, Jin L, Xu X, Lin N, Lei B and Shen H: Pathological and computed tomography findings of lymphoepithelioma-like gastric carcinoma with epithelioid granulomas: A case report. Oncol Lett. 5:549–551. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Tamura T, Hamada T, Sako T, Makihara K, Yamada K, Kashima K, Yokoyama S, Hirata K, Hachiya Y, Fukuyama T and Hirano Y: Lymphoepithelioma-like carcinoma of the stomach with epithelioid granulomas. Case Rep Gastroenterol. 4:361–368. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cao H, Xie J, Qian Y, Wu Y and Tang Z: Lymphoepithelioma‑like gastric carcinoma treated with partial gastrectomy: Two case reports. Oncol Lett 18: 545-552, 2019.
APA
Cao, H., Xie, J., Qian, Y., Wu, Y., & Tang, Z. (2019). Lymphoepithelioma‑like gastric carcinoma treated with partial gastrectomy: Two case reports. Oncology Letters, 18, 545-552. https://doi.org/10.3892/ol.2019.10368
MLA
Cao, H., Xie, J., Qian, Y., Wu, Y., Tang, Z."Lymphoepithelioma‑like gastric carcinoma treated with partial gastrectomy: Two case reports". Oncology Letters 18.1 (2019): 545-552.
Chicago
Cao, H., Xie, J., Qian, Y., Wu, Y., Tang, Z."Lymphoepithelioma‑like gastric carcinoma treated with partial gastrectomy: Two case reports". Oncology Letters 18, no. 1 (2019): 545-552. https://doi.org/10.3892/ol.2019.10368
Copy and paste a formatted citation
x
Spandidos Publications style
Cao H, Xie J, Qian Y, Wu Y and Tang Z: Lymphoepithelioma‑like gastric carcinoma treated with partial gastrectomy: Two case reports. Oncol Lett 18: 545-552, 2019.
APA
Cao, H., Xie, J., Qian, Y., Wu, Y., & Tang, Z. (2019). Lymphoepithelioma‑like gastric carcinoma treated with partial gastrectomy: Two case reports. Oncology Letters, 18, 545-552. https://doi.org/10.3892/ol.2019.10368
MLA
Cao, H., Xie, J., Qian, Y., Wu, Y., Tang, Z."Lymphoepithelioma‑like gastric carcinoma treated with partial gastrectomy: Two case reports". Oncology Letters 18.1 (2019): 545-552.
Chicago
Cao, H., Xie, J., Qian, Y., Wu, Y., Tang, Z."Lymphoepithelioma‑like gastric carcinoma treated with partial gastrectomy: Two case reports". Oncology Letters 18, no. 1 (2019): 545-552. https://doi.org/10.3892/ol.2019.10368
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