Twist1 promotes astrocytoma development by stimulating vasculogenic mimicry

  • Authors:
    • Wei Cao
    • Can Xu
    • Xinxing Li
    • Xianghong Yang
  • View Affiliations

  • Published online on: May 21, 2019     https://doi.org/10.3892/ol.2019.10380
  • Pages: 846-855
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Astrocytomas are one of the most vascularized types tumor in human cancers. Micro‑vascular proliferation is an important factor for the classification of astrocytoma. Vasculogenic mimicry (VM) is a novel tumor vascular model that develops independently of endothelial cells, and serves an important role in astrocytoma. Twist family bHLH transcription factor 1 (Twist1) is able to regulate the formation of VM; thus in the present study, the expression and importance of Twist1 was studied in astrocytoma tissues. The present study confirmed that the expression of Twist1 was associated with the grade of astrocytoma. Twist1 promotes the formation of VM and the development of astrocytomas, and may also regulate the formation of VM via vascular endothelial‑cadherin and matrix metalloproteinase‑9.
View Figures
View References

Related Articles

Journal Cover

July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cao W, Xu C, Li X and Yang X: Twist1 promotes astrocytoma development by stimulating vasculogenic mimicry. Oncol Lett 18: 846-855, 2019
APA
Cao, W., Xu, C., Li, X., & Yang, X. (2019). Twist1 promotes astrocytoma development by stimulating vasculogenic mimicry. Oncology Letters, 18, 846-855. https://doi.org/10.3892/ol.2019.10380
MLA
Cao, W., Xu, C., Li, X., Yang, X."Twist1 promotes astrocytoma development by stimulating vasculogenic mimicry". Oncology Letters 18.1 (2019): 846-855.
Chicago
Cao, W., Xu, C., Li, X., Yang, X."Twist1 promotes astrocytoma development by stimulating vasculogenic mimicry". Oncology Letters 18, no. 1 (2019): 846-855. https://doi.org/10.3892/ol.2019.10380