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Case Report Open Access

Cystic and solitary nodular pulmonary metastases in a patient with low‑grade endometrial stromal sarcoma: A case report and literature review

  • Authors:
    • Yang Xu
    • Zhi‑Xin Liang
    • Jun‑Tang Guo
    • Xin Su
    • Yun‑Long Lu
    • Xi‑Zhou Guan
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China, Department of Thoracic Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China, Department of Respiratory Diseases, Hainan Branch of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572013, P.R. China, Department of Pathology, Hainan Branch of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572013, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1133-1144
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    Published online on: May 30, 2019
       https://doi.org/10.3892/ol.2019.10409
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Abstract

Pulmonary metastases of endometrial stromal sarcoma (ESS) are uncommon and can be difficult to diagnose. The aims of the present study were to investigate the clinical and pathological features, and enhance the awareness of pulmonary metastases in patients with low‑grade ESS. The study reports a case of low‑grade ESS that resulted in cystic and nodular pulmonary metastases. Furthermore, the PubMed database was searched using ‘pulmonary metastases of low‑grade endometrial stromal sarcoma’ as the key phrase. The literature on pulmonary metastases of low‑grade ESS was reviewed and 35 cases were included in the present study. The clinical manifestations, imaging data, pathological features, treatment and prognosis of the 35 previously reported cases and the current case were retrospectively analyzed. The age range of the 36 patients diagnosed with low‑grade ESS was 28‑65 years. The time period from confirmation of ESS to lung metastases was 1.5‑27 years. In 50% of the patients, the pulmonary metastases were asymptomatic. The most common pulmonary symptom was dyspnea, followed by chest pain, pneumothorax and coughing. The most common chest imaging presentation was multiple pulmonary nodules, followed by a solitary nodule or mass. Histology was used to identify that the pulmonary metastases had the pathological features of low‑grade ESS. The immunohistochemical results demonstrated strong diffuse immunoreactivity for cluster of differentiation 10, estrogen receptor and progesterone receptor in almost all the specimens. The review of the literature revealed that pulmonary metastases from low‑grade ESS are rare but not negligible. Furthermore, the detailed clinical information, imaging findings and immunohistochemical detection are important for making a diagnosis.
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Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Liang ZX, Guo JT, Su X, Lu YL and Guan XZ: Cystic and solitary nodular pulmonary metastases in a patient with low‑grade endometrial stromal sarcoma: A case report and literature review. Oncol Lett 18: 1133-1144, 2019.
APA
Xu, Y., Liang, Z., Guo, J., Su, X., Lu, Y., & Guan, X. (2019). Cystic and solitary nodular pulmonary metastases in a patient with low‑grade endometrial stromal sarcoma: A case report and literature review. Oncology Letters, 18, 1133-1144. https://doi.org/10.3892/ol.2019.10409
MLA
Xu, Y., Liang, Z., Guo, J., Su, X., Lu, Y., Guan, X."Cystic and solitary nodular pulmonary metastases in a patient with low‑grade endometrial stromal sarcoma: A case report and literature review". Oncology Letters 18.2 (2019): 1133-1144.
Chicago
Xu, Y., Liang, Z., Guo, J., Su, X., Lu, Y., Guan, X."Cystic and solitary nodular pulmonary metastases in a patient with low‑grade endometrial stromal sarcoma: A case report and literature review". Oncology Letters 18, no. 2 (2019): 1133-1144. https://doi.org/10.3892/ol.2019.10409
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Liang ZX, Guo JT, Su X, Lu YL and Guan XZ: Cystic and solitary nodular pulmonary metastases in a patient with low‑grade endometrial stromal sarcoma: A case report and literature review. Oncol Lett 18: 1133-1144, 2019.
APA
Xu, Y., Liang, Z., Guo, J., Su, X., Lu, Y., & Guan, X. (2019). Cystic and solitary nodular pulmonary metastases in a patient with low‑grade endometrial stromal sarcoma: A case report and literature review. Oncology Letters, 18, 1133-1144. https://doi.org/10.3892/ol.2019.10409
MLA
Xu, Y., Liang, Z., Guo, J., Su, X., Lu, Y., Guan, X."Cystic and solitary nodular pulmonary metastases in a patient with low‑grade endometrial stromal sarcoma: A case report and literature review". Oncology Letters 18.2 (2019): 1133-1144.
Chicago
Xu, Y., Liang, Z., Guo, J., Su, X., Lu, Y., Guan, X."Cystic and solitary nodular pulmonary metastases in a patient with low‑grade endometrial stromal sarcoma: A case report and literature review". Oncology Letters 18, no. 2 (2019): 1133-1144. https://doi.org/10.3892/ol.2019.10409
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