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Mechanism of cadmium poisoning on testicular injury in mice

  • Authors:
    • Yaping Ren
    • Wenhua Shao
    • Lijun Zuo
    • Wei Zhao
    • Haizhang Qin
    • Yingjie Hua
    • Dejie Lu
    • Chao Mi
    • Sien Zeng
    • Liao Zu
  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, Guilin Medical University, Guilin, Guangxi 541004, P.R. China, Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi 541004, P.R. China, Department of Pathology and Physiopathology, Guilin Medical University, Guilin, Guangxi 541004, P.R. China, Evidence Identification Center, The Seven Star Branch in The Guilin City Public Security Bureau, Guilin, Guangxi 541004, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1035-1042
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    Published online on: May 30, 2019
       https://doi.org/10.3892/ol.2019.10418
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Abstract

Cadmium is a heavy metal that is toxic to humans and the reproductive system. The present study aimed to investigate the mechanisms of cadmium‑induced reproductive toxicity in a male Institute of Cancer Research mouse model of cadmium poisoning. Changes in luteinizing hormone receptor (LHR), 17α‑hydroxylase and endothelial nitric oxide (NO) synthase (eNOS) expression levels were examined. A total of 24 male mice (4‑week‑old) were randomly divided into four groups (normal control group and low, medium and high cadmium groups) and subjected to gavage treatment with normal saline or cadmium‑containing saline solutions for 8 weeks prior to sacrifice. To assess testicular injury, serum androgen levels were determined by ELISA, testicular tissue pathological changes were evaluated using hematoxylin and eosin staining. In addition, LHR, 17α‑hydroxylase and eNOS expressions levels were examined by western blotting, and apoptosis was examined with a terminal deoxynucleotidyl transferase dUTP nick end labeling assay. The results demonstrated that the severity of testes injury increased with cadmium concentration. In addition, LHR, 17α‑hydroxylase and eNOS expression levels increased with low and medium concentrations of cadmium; however, they were decreased following treatment with high concentrations of cadmium. The results from the present study demonstrated that cadmium altered LHR, 17α‑hydroxylase and eNOS expression levels in testicular stromal cells, which may impact testosterone synthesis. Furthermore, NO was suggested to be involved in cadmium‑induced testicular injury by measurements of eNOS expression in testicular stromal cells.
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View References

1 

Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR Jr, Lee DH, Shioda T, Soto AM, vom Saal FS, Welshons WV, et al: Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses. Endocr Rev. 33:378–455. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Medina MF, Arrieta MC, Villafañe MN, Klyver SMR, Odstrcil IMA and González ME: Early signs of toxicity in testes and sperm of rats exposed to low cadmium doses. Toxicol Ind Health. 33:576–587. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Akinloye O, Arowojolu AO, Shittu OB and Anetor JI: Cadmium toxicity: A possible cause of male infertility in Nigeria. Reprod Biol. 6:17–30. 2006.PubMed/NCBI

4 

Luevano J and Damodaran C: A review of molecular events of cadmium-induced carcinogenesis. J Environ Pathol Toxicol Oncol. 33:183–194. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Niknafs B, Salehnia M and Kamkar M: Induction and determination of apoptotic and necrotic cell death by cadmium chloride in testis tissue of mouse. J Reprod Infertil. 16:24–29. 2015.PubMed/NCBI

6 

De Angelis C, Galdiero M, Pivonello C, Salzano C, Gianfrilli D, Piscitelli P, Lenzi A, Colao A and Pivonello R: The environment and male reproduction: The effect of cadmium exposure on reproductive function and its implication in fertility. Reprod Toxicol. 73:105–127. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Marettoá E, Maretta M and Leqáth J: Toxic effects of cadmium on testis of birds and mammals: A review. Anim Reprod Sci. 155:1–10. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Verqilio CS, Moreira RV, Carvalho CE and Melo EJ: Evolution of cadmium effects in the testis and sperm of the tropical fish Gymnotus carapo. Tissue Cell. 47:132–139. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Yang Q, Li P, Wen Y, Li S, Chen J, Liu X, Wang L and Li X: Cadmium inhibits lysine acetylation and succinylation inducing testicular injury of mouse during development. Toxicol Lett. 291:112–120. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Ali I, Damdimopoulou P, Stenius U, Adamsson A, Mäkelä SI, Åkesson A, Berglund M, Håkansson H and Halldin K: Cadmium-induced effects on cellular signaling pathways in the liver of transgenic estrogen reporter mice. Toxicol Sci. 127:66–75. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Schneider SN, Liu Z, Wang B, Miller ML, Afton SE, Soleimani M and Nebert DW: Oral cadmium in mice carrying 5 versus 2 copies of the Slc39a8 gene: Comparison of uptake, distribution, metal content, and toxicity. Int J Toxicol. 33:14–20. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Hu H, Lu X, Cen X, Chen X, Li F and Zhong S: RNA-Seq identifies key reproductive gene expression alterations in response to cadmium exposure. Biomed Res Int. 2014:5292712014. View Article : Google Scholar : PubMed/NCBI

13 

Angenard G, Muczynski V, Coffigny H, Pairault C, Duquenne C, Frydman R, Habert R, Rouiller-Fabre V and Livera G: Cadmium increases human fetal germ cell apoptosis. Environ Health Perspect. 118:331–337. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Singh KP, Kumari R, Pevey C, Jackson D and DuMond JW: Long duration exposure to cadmium leads to increased cell survival, decreased DNA repair capacity, and genomic instability in mouse testicular Leydig cells. Cancer Lett. 279:84–92. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Ji YL, Wang H, Zhao XF, Wang Q, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH and Xu DX: Crosstalk between endoplasmic reticulum stress and mitochondrial pathway mediates cadmium-induced germ cell apoptosis in testes. Toxicol Sci. 124:446–459. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Oliveira H, Lopes T, Almeida T, Pereira Mde L and Santos C: Cadmium-induced genetic instability in mice testis. Hum Exp Toxicol. 31:1228–1236. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Veeriah V, Saran U, Swaminathan A, Balaguru UM, Thangaraj P, Nagarajan S, Rajendran VK and Chatterjee S: Cadmium-induced embryopathy: Nitric oxide rescues teratogenic effects of Cadmium. Toxicol Sci. 144:90–104. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Seid Alian N, Khodarahmi P and Naseh V: The effect of cadmium on apoptotic genes mRNA expression of Bax and Bcl-2 in small intestine of rats. Iran J Pathol. 13:408–414. 2018.PubMed/NCBI

19 

Breton J, Le Clère K, Daniel C, Sauty M, Nakab L, Chassat T, Dewulf J, Penet S, Carnoy C, Thomas P, et al: Chronic ingestion of cadmium and lead alters the bioavailability of essential and heavy metals, gene expression pathways and genotoxicity in mouse intestine. Arch Toxicol. 87:1787–1795. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Uno Y, Hosaka S and Yamazaki H: Identification and analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1 and CYP51A1 in cynomolgus macaques. J Vet Med Sci. 76:1647–1650. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Chen H, Ge RS and Zirkin BR: Leydig cells: From stem cells to aging. Mol Cell Endocrinol. 306:9–16. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Ge R, Chen G and Hardy MP: The role of the Leydig cell in spermatogenic function. Adv Exp Med Biol. 636:255–269. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Smith LB and Walker WH: The regulation of spermatogenesis by androgens. Semin Cell Dev Biol. 30:2–13. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Rey RA, Musse M, Venara M and Chemes HE: Ontogeny of the androgen receptor expression in the fetal and postnatal testis: Its relevance on Sertoli cell maturation and the onset of adult spermatogenesis. Microsc Res Tech. 72:787–95. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Chang C, Chen YT, Yeh SD, Xu Q, Wang RS, Guillou F, Lardy H and Yeh S: Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells. Proc Natl Acad Sci USA. 101:6876–6881. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Zhang F and Liao L: Role and significance of nitric oxide neurochemical remodeling in lower urinary tract dysfunction after spinal cord injury. Chin J Urol. 332012.

27 

Ren YP, Sun L, Shao XY, Chen J, Xiong B and Nong LL: Expressions of eNOS and cytochrome P450 in the testis of sexually mature SD rats and their significance. Zhonghua Nan Ke Xue. 15:911–914. 2009.(In Chinese). PubMed/NCBI

28 

Lim KH, Ancrile BB, Kashatus DF and Counter CM: Tumour maintenance is mediated by eNOS. Nature. 452:646–649. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Alpcan S, Başar H, Aydos TR, Kul O, Kısa Ü and Başar MM: Apoptosis in testicular tissue of rats after vasectomy: Evaluation of eNOS, iNOS immunoreactivities and the effects of ozone therapy. Turk J Urol. 40:199–206. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Kondo Y, Ishikawa T, Yamaguchi K, Yada T and Fujisawa M: Oral administration of tetrahydrobiopterin attenuates testicular damage by reducing nitric oxide synthase activity in a cryptorchid mouse model. J Androl. 29:153–163. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Guo J, Jia Y, Tao SX, Li YC, Zhang XS, Hu ZY, Chiang N, Lue YH, Hikim AP, Swerdloff RS, et al: Expression of nitric oxide synthase during germ cell apoptosis in testis of cynomolgus monkey after testosterone and heat treatment. J Androl. 30:190–199. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Zheng LP, Zhu X, Yang L, et al: Analysis and correlation study of trace elements in blood and semen of male sterile patients. Mod Prev Med. 1464–1466. 2012.

33 

Cheng DZ, Du AL, Li CS, et al: Scavenging of superoxide free radicals generated by autooxidation of pyrogallol with ginger extract. Chin Spices. 35–39. 2014.

34 

Saito H, Good S, Sato S, Ito A, Ikumi Y, Tanaka S, Ida T, Fujii S, Akaike T and Shimokawa H: Important role of endothelial caveolin-1 in the protective role of endothelium-dependent hyperpolarization against nitric oxide-mediated nitrative stress in microcirculation in mice. J Cardiovasc Pharmacol. 71:113–126. 2018.PubMed/NCBI

35 

Vladimir K: Gross anatomy, anatomy and normative biology, The Laboratory Mouse second edition, Chapter 2.2. 145–149. 2012.

36 

Ohtani K, Yanagiba Y, Ashimori A, Takeuchi A, Takada N, Togawa M, Hasegawa T, Ikeda M and Miura N: Influence of injection timing on severity of cadmium-induced testicular toxicity in mice. J Toxicol Sci. 38:145–150. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Ogawa Y, Itoh M, Hirai S, Suna S, Naito M, Qu N, Terayama H, Ikeda A, Miyaso H, Matsuno Y, et al: Cadmium exposure increases susceptibility to testicular autoimmunity in mice. J Appl Toxicol. 33:652–660. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Wu S, Chen Y, Fajobi T, DiVall SA, Chang C, Yeh S and Wolfe A: Conditional knockout of the androgen receptor in gonadotropes reveals crucial roles for androgen in gonadotropin synthesis and surge in female mice. Mol Endocrinol. 28:1670–1681. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Denolet E, De Gendt K, Allemeersch J, Engelen K, Marchal K, Van Hummelen P, Tan KA, Sharpe RM, Saunders PT, Swinnen JV and Verhoeven G: The effect of a Sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice. Mol Endocrinol. 20:321–334. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Welsh M, Saunders PT, Atanassova N, Sharpe RM and Smith LB: Androgen action via testicular peritubular myoid cells is essential for male fertility. FASEB J. 23:4218–4230. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Iwasa T, Matsuzaki T, Yano K, Yanagihara R, Mayila Y and Irahara M: The effects of chronic testosterone administration on hypothalamic gonadotropin-releasing hormone regulatory factors (Kiss1, NKB, pDyn and RFRP) and their receptors in female rats. Gynecol Endocrinol. 34:437–441. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Telisman S, Colak B, Pizent A, Jurasović J and Cvitković P: Reproductive toxicity of low-level lead exposure in men. Environ Res. 105:256–266. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Meeker JD, Rossano MG, Protas B, Padmanahban V, Diamond MP, Puscheck E, Daly D, Paneth N and Wirth JJ: Environmental exposure to metals and male reproductive hormones: Circulating testosterone is inversely associated with blood molybdenum. Fertil Steril. 93:130–140. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Jurasović J, Cvitković P, Pizent A, Colak B and Telisman S: Semen quality and reproductive endocrine function with regard to blood cadmium in Croatian male subjects. Biometals. 17:735–743. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Weinberg JB, Doty E, Bonaventura J and Haney AF: Nitric oxide inhibition of human sperm motility. Fertil Steril. 64:408–413. 1995. View Article : Google Scholar : PubMed/NCBI

46 

Hellstrom WJ, Bell M, Wang R and Sikka SC: Effect of sodium nitroprusside on sperm motility, viability, and lipid peroxidation. Fertil Steril. 61:1117–1122. 1994. View Article : Google Scholar : PubMed/NCBI

47 

Prozialeck WC, Edwards JR, Nebert DW, Woods JM, Barchowsky A and Atchison WD: The vascular system as a target of metal toxicity. Toxicol Sci. 102:207–218. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Chen CA, Wang TY, Varadharaj S, Reyes LA, Hemann C, Talukder MA, Chen YR, Druhan LJ and Zweier JL: S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. Nature. 468:1115–1118. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ren Y, Shao W, Zuo L, Zhao W, Qin H, Hua Y, Lu D, Mi C, Zeng S, Zu L, Zu L, et al: Mechanism of cadmium poisoning on testicular injury in mice. Oncol Lett 18: 1035-1042, 2019.
APA
Ren, Y., Shao, W., Zuo, L., Zhao, W., Qin, H., Hua, Y. ... Zu, L. (2019). Mechanism of cadmium poisoning on testicular injury in mice. Oncology Letters, 18, 1035-1042. https://doi.org/10.3892/ol.2019.10418
MLA
Ren, Y., Shao, W., Zuo, L., Zhao, W., Qin, H., Hua, Y., Lu, D., Mi, C., Zeng, S., Zu, L."Mechanism of cadmium poisoning on testicular injury in mice". Oncology Letters 18.2 (2019): 1035-1042.
Chicago
Ren, Y., Shao, W., Zuo, L., Zhao, W., Qin, H., Hua, Y., Lu, D., Mi, C., Zeng, S., Zu, L."Mechanism of cadmium poisoning on testicular injury in mice". Oncology Letters 18, no. 2 (2019): 1035-1042. https://doi.org/10.3892/ol.2019.10418
Copy and paste a formatted citation
x
Spandidos Publications style
Ren Y, Shao W, Zuo L, Zhao W, Qin H, Hua Y, Lu D, Mi C, Zeng S, Zu L, Zu L, et al: Mechanism of cadmium poisoning on testicular injury in mice. Oncol Lett 18: 1035-1042, 2019.
APA
Ren, Y., Shao, W., Zuo, L., Zhao, W., Qin, H., Hua, Y. ... Zu, L. (2019). Mechanism of cadmium poisoning on testicular injury in mice. Oncology Letters, 18, 1035-1042. https://doi.org/10.3892/ol.2019.10418
MLA
Ren, Y., Shao, W., Zuo, L., Zhao, W., Qin, H., Hua, Y., Lu, D., Mi, C., Zeng, S., Zu, L."Mechanism of cadmium poisoning on testicular injury in mice". Oncology Letters 18.2 (2019): 1035-1042.
Chicago
Ren, Y., Shao, W., Zuo, L., Zhao, W., Qin, H., Hua, Y., Lu, D., Mi, C., Zeng, S., Zu, L."Mechanism of cadmium poisoning on testicular injury in mice". Oncology Letters 18, no. 2 (2019): 1035-1042. https://doi.org/10.3892/ol.2019.10418
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