Open Access

Expressions of 10 genes as candidate predictors of recurrence in stage III colon cancer patients receiving adjuvant oxaliplatin‑based chemotherapy

  • Authors:
    • Kensuke Kumamoto
    • Yutaka Nakachi
    • Yosuke Mizuno
    • Masaru Yokoyama
    • Keiichiro Ishibashi
    • Chihiro Kosugi
    • Keiji Koda
    • Michiya Kobayashi
    • Kohji Tanakaya
    • Toshio Matsunami
    • Hidetaka Eguchi
    • Yasushi Okazaki
    • Hideyuki Ishida
  • View Affiliations

  • Published online on: June 5, 2019     https://doi.org/10.3892/ol.2019.10437
  • Pages: 1388-1394
  • Copyright: © Kumamoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Approximately 30% patients with stage III colon cancer (CC) develop local recurrence and/or distant metastasis, even if postoperative adjuvant chemotherapy with oxaliplatin plus 5‑fluorouracil and leucovorin (5‑FU/LV) has been completed. In the present study, molecular analysis was performed to identify molecular markers of tumor recurrence in patients with stage III CC receiving oxaliplatin‑based adjuvant chemotherapy. The FACOS study was conducted as a phase II study to evaluate the safety and efficacy of oxaliplatin‑based treatment for stage III CC patients. Of the 132 CC patients enrolled in the present study, gene expression analysis using a microarray was conducted in 51 patients. Of these 51 patients, 6 developed recurrence within 5 years. The topmost 5% genes that showed differential expressions between cases that developed/did not develop recurrence were selected, and a set of predictive molecular markers for recurrence was identified. Of the 34,694 genes in the microarray, 1,734 genes were extracted as topmost 5% genes showing differential expressions between cases with and without recurrence. Among these, 10 genes, includingADH1A, ADH1C, CA12, CHP2, HMGCS2, SNAR‑A1, TPI1, MS4A12, PLA2G10 and PTPRO, were identified as markers that could clearly divide patients with and without recurrence. Although several prediction models of tumor recurrence have been reported for CC, the set of 10 genes that the present study identified may be useful to predict the risk of recurrence in stage III CC patients receiving oxaliplatin‑based adjuvant chemotherapy. Based on these results, high‑risk patients with CC should be carefully observed to detect tumor recurrence during the follow‑up period.
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August-2019
Volume 18 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kumamoto K, Nakachi Y, Mizuno Y, Yokoyama M, Ishibashi K, Kosugi C, Koda K, Kobayashi M, Tanakaya K, Matsunami T, Matsunami T, et al: Expressions of 10 genes as candidate predictors of recurrence in stage III colon cancer patients receiving adjuvant oxaliplatin‑based chemotherapy. Oncol Lett 18: 1388-1394, 2019
APA
Kumamoto, K., Nakachi, Y., Mizuno, Y., Yokoyama, M., Ishibashi, K., Kosugi, C. ... Ishida, H. (2019). Expressions of 10 genes as candidate predictors of recurrence in stage III colon cancer patients receiving adjuvant oxaliplatin‑based chemotherapy. Oncology Letters, 18, 1388-1394. https://doi.org/10.3892/ol.2019.10437
MLA
Kumamoto, K., Nakachi, Y., Mizuno, Y., Yokoyama, M., Ishibashi, K., Kosugi, C., Koda, K., Kobayashi, M., Tanakaya, K., Matsunami, T., Eguchi, H., Okazaki, Y., Ishida, H."Expressions of 10 genes as candidate predictors of recurrence in stage III colon cancer patients receiving adjuvant oxaliplatin‑based chemotherapy". Oncology Letters 18.2 (2019): 1388-1394.
Chicago
Kumamoto, K., Nakachi, Y., Mizuno, Y., Yokoyama, M., Ishibashi, K., Kosugi, C., Koda, K., Kobayashi, M., Tanakaya, K., Matsunami, T., Eguchi, H., Okazaki, Y., Ishida, H."Expressions of 10 genes as candidate predictors of recurrence in stage III colon cancer patients receiving adjuvant oxaliplatin‑based chemotherapy". Oncology Letters 18, no. 2 (2019): 1388-1394. https://doi.org/10.3892/ol.2019.10437