Open Access

ST6GAL1: A key player in cancer (Review)

  • Authors:
    • Rebecca Garnham
    • Emma Scott
    • Karen E. Livermore
    • Jennifer Munkley
  • View Affiliations

  • Published online on: June 7, 2019     https://doi.org/10.3892/ol.2019.10458
  • Pages: 983-989
  • Copyright: © Garnham et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Aberrant glycosylation is a universal feature of cancer cells and there is now overwhelming evidence that glycans can modulate pathways intrinsic to tumour cell biology. Glycans are important in all of the cancer hallmarks and there is a renewed interest in the glycomic profiling of tumours to improve early diagnosis, determine patient prognosis and identify targets for therapeutic intervention. One of the most widely occurring cancer associated changes in glycosylation is abnormal sialylation which is often accompanied by changes in sialyltransferase activity. Several sialyltransferases are implicated in cancer, but in recent years ST6 β‑galactoside α‑2,6‑sialyltransferase 1 (ST6GAL1) has become increasingly dominant in the literature. ST6GAL1 catalyses the addition of α2,6‑linked sialic acids to terminal N‑glycans and can modify glycoproteins and/or glycolipids. ST6GAL1 is upregulated in numerous types of cancer (including pancreatic, prostate, breast and ovarian cancer) and can promote growth, survival and metastasis. The present review discusses ST6GAL in relation to the hallmarks of cancer, and highlights its key role in multiple mechanisms intrinsic to tumour cell biology.
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August-2019
Volume 18 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Garnham R, Scott E, Livermore KE and Munkley J: ST6GAL1: A key player in cancer (Review). Oncol Lett 18: 983-989, 2019
APA
Garnham, R., Scott, E., Livermore, K.E., & Munkley, J. (2019). ST6GAL1: A key player in cancer (Review). Oncology Letters, 18, 983-989. https://doi.org/10.3892/ol.2019.10458
MLA
Garnham, R., Scott, E., Livermore, K. E., Munkley, J."ST6GAL1: A key player in cancer (Review)". Oncology Letters 18.2 (2019): 983-989.
Chicago
Garnham, R., Scott, E., Livermore, K. E., Munkley, J."ST6GAL1: A key player in cancer (Review)". Oncology Letters 18, no. 2 (2019): 983-989. https://doi.org/10.3892/ol.2019.10458