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Identification of a miRNA‑mRNA network associated with lymph node metastasis in colorectal cancer

  • Authors:
    • Qiang Ju
    • Yan‑Jie Zhao
    • Yong Dong
    • Cong Cheng
    • Shaoqiang Zhang
    • Yuanming Yang
    • Ping Li
    • Dongmei Ge
    • Bo Sun
  • View Affiliations / Copyright

    Affiliations: Department of Blood Transfusion, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, School of Public Health, Qingdao University, Qingdao, Shandong 266003, P.R. China
    Copyright: © Ju et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1179-1188
    |
    Published online on: June 7, 2019
       https://doi.org/10.3892/ol.2019.10460
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Abstract

Lymph node metastasis is an important step in the progression of colorectal cancer (CRC); however, the underlying mechanisms are still unknown. The aim of the present study was to identify the gene expression pattern during lymph node metastasis in CRC and to identify upstream microRNAs (miRNAs) to explore the underlying mechanisms in detail. A total of 305 differently expressed genes (DEGs) were identified, including 227 upregulated genes and 78 downregulated genes in lymph node metastasis. Pathway and process enrichment analysis demonstrated that DEGs were significantly enriched in ‘NABA CORE MATRISOME’, ‘extracellular matrix assembly’, ‘antimicrobial humoral response’ and ‘Toll‑like receptor signaling’ pathways. The top 10 hub genes were identified by protein‑protein interaction network, and sub‑networks revealed that these genes were involved in significant pathways, including ‘neutrophil chemotaxis’ and ‘Smooth Muscle Contraction’. In addition, 73 mature differently expressed miRNAs associated with lymph node metastasis were identified, of which 48 were upregulated and 25 were downregulated. Six miRNAs were identified to regulate DEGs. Additionally, based on the relationship between miRNAs and transcription factors, a miRNA‑TF‑mRNA network was constructed. In conclusion, DEGs, miRNAs and their interactions and pathways were identified in lymph node metastasis in CRC, which provided insight into the mechanism of CRC metastasis and may be used to develop novel targets for CRC treatment.
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View References

1 

Liu K, Yao H, Wen Y, Zhao H, Zhou N, Lei S and Xiong L: Functional role of a long non-coding RNA LIFR-AS1/miR-29a/TNFAIP3 axis in colorectal cancer resistance to pohotodynamic therapy. Biochim Biophys Acta Mol Basis Dis. 1864:2871–2880. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A and Jemal A: Colorectal cancer statistics, 2017. CA Cancer J Clin. 67:177–193. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Stintzing S, Tejpar S, Gibbs P, Thiebach L and Lenz HJ: Understanding the role of primary tumour localisation in colorectal cancer treatment and outcomes. Eur J Cancer. 84:69–80. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Chaffer CL and Weinberg RA: A perspective on cancer cell metastasis. Science. 331:1559–1564. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Shinagawa T, Tanaka T, Nozawa H, Emoto S, Murono K, Kaneko M, Sasaki K, Otani K, Nishikawa T, Hata K, et al: Comparison of the guidelines for colorectal cancer in Japan, the USA and Europe. Ann Gastroenterol Surg. 2:6–12. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Zhang K, Zhang X, Cai Z, Zhou J, Cao R, Zhao Y, Chen Z, Wang D, Ruan W, Zhao Q, et al: A novel class of microRNA-recognition elements that function only within open reading frames. Nat Struct Mol Biol. 25:1019–1027. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Long JM, Maloney B, Rogers JT and Lahiri DK: Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer's disease. Mol Psychiatry. 24:345–363. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Ludwig N, Leidinger P, Becker K, Backes C, Fehlmann T, Pallasch C, Rheinheimer S, Meder B, Stahler C, Meese E and Keller A: Distribution of miRNA expression across human tissues. Nucleic Acids Res. 44:3865–3877. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Ha M and Kim VN: Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 15:509–524. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Chipman LB and Pasquinelli AE: miRNA targeting: Growing beyond the seed. Trends Genet. 35:215–222. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Uhlmann S, Mannsperger H, Zhang JD, Horvat EA, Schmidt C, Kublbeck M, Henjes F, Ward A, Tschulena U, Zweig K, et al: Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer. Mol Syst Biol. 8:5702012. View Article : Google Scholar : PubMed/NCBI

13 

Sells E, Pandey R, Chen H, Skovan BA, Cui H and Ignatenko NA: Specific microRNA-mRNA regulatory network of colon cancer invasion mediated by tissue kallikrein-related peptidase 6. Neoplasia. 19:396–411. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Hanauer DA, Rhodes DR, Sinha-Kumar C and Chinnaiyan AM: Bioinformatics approaches in the study of cancer. Curr Mol Med. 7:133–141. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Karagkouni D, Paraskevopoulou MD, Chatzopoulos S, Vlachos IS, Tastsoglou S, Kanellos I, Papadimitriou D, Kavakiotis I, Maniou S, Skoufos G, et al: DIANA-TarBase v8: A decade-long collection of experimentally supported miRNA-gene interactions. Nucleic Acids Res. 46:D239–D245. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Chou CH, Shrestha S, Yang CD, Chang NW, Lin YL, Liao KW, Huang WC, Sun TH, Tu SJ, Lee WH, et al: miRTarBase update 2018: A resource for experimentally validated microRNA-target interactions. Nucleic Acids Res. 46:D296–D302. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Ozawa T, Kandimalla R, Gao F, Nozawa H, Hata K, Nagata H, Okada S, Izumi D, Baba H, Fleshman J, et al: A MicroRNA signature associated with metastasis of T1 colorectal cancers to lymph nodes. Gastroenterology. 154:844–848. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Gebert LFR and MacRae IJ: Regulation of microRNA function in animals. Nat Rev Mol Cell Biol. 20:21–37. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Sakai E, Fukuyo M, Ohata K, Matsusaka K, Doi N, Mano Y, Takane K, Abe H, Yagi K, Matsuhashi N, et al: Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway. Int J Cancer. 138:1634–1644. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Ma Y, Peng J, Liu W, Zhang P, Huang L, Gao B, Shen T, Zhou Y, Chen H, Chu Z, et al: Proteomics identification of desmin as a potential oncofetal diagnostic and prognostic biomarker in colorectal cancer. Mol Cell Proteomics. 8:1878–1890. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Arentz G, Chataway T, Price TJ, Izwan Z, Hardi G, Cummins AG and Hardingham JE: Desmin expression in colorectal cancer stroma correlates with advanced stage disease and marks angiogenic microvessels. Clin Proteomics. 8:162011. View Article : Google Scholar : PubMed/NCBI

22 

Traicoff JL, De Marchis L, Ginsburg BL, Zamora RE, Khattar NH, Blanch VJ, Plummer S, Bargo SA, Templeton DJ, Casey G and Kaetzel CS: Characterization of the human polymeric immunoglobulin receptor (PIGR) 3′UTR and differential expression of PIGR mRNA during colon tumorigenesis. J Biomed Sci. 10:792–804. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Agesen TH, Sveen A, Merok MA, Lind GE, Nesbakken A, Skotheim RI and Lothe RA: ColoGuideEx: A robust gene classifier specific for stage II colorectal cancer prognosis. Gut. 61:1560–1567. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Li Y, Kuscu C, Banach A, Zhang Q, Pulkoski-Gross A, Kim D, Liu J, Roth E, Li E, Shroyer KR, et al: miR-181a-5p inhibits cancer cell migration and angiogenesis via downregulation of matrix metalloproteinase-14. Cancer Res. 75:2674–2685. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Przybyla L, Muncie JM and Weaver VM: Mechanical control of epithelial-to-mesenchymal transitions in development and cancer. Annu Rev Cell Dev Biol. 32:527–554. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Gonzalez-Avila G, Sommer B, Mendoza-Posada DA, Ramos C, Garcia-Hernandez AA and Falfan-Valencia R: Matrix metalloproteinases participation in the metastatic process and their diagnostic and therapeutic applications in cancer. Crit Rev Oncol Hematol. 137:57–83. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Weng MT, Tsao PN, Lin HL, Tung CC, Change MC, Chang YT, Wong JM and Wei SC: Hes1 increases the invasion ability of colorectal cancer cells via the STAT3-MMP14 pathway. PLoS One. 10:e01443222015. View Article : Google Scholar : PubMed/NCBI

28 

Andarawewa KL, Motrescu ER, Chenard MP, Gansmuller A, Stoll I, Tomasetto C and Rio MC: Stromelysin-3 is a potent negative regulator of adipogenesis participating to cancer cell-adipocyte interaction/crosstalk at the tumor invasive front. Cancer Res. 65:10862–10871. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Doll D, Keller L, Maak M, Boulesteix AL, Siewert JR, Holzmann B and Janssen KP: Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival. Int J Colorectal Dis. 25:573–581. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Yamanaka R, Abe E, Sato T, Hayano A and Takashima Y: Secondary intracranial tumors following radiotherapy for pituitary adenomas: A systematic review. Cancers (Basel); 9(pii): pp. E1032017, PubMed/NCBI

31 

Jeon M, You D, Bae SY, Kim SW, Nam SJ, Kim HH, Kim S and Lee JE: Dimerization of EGFR and HER2 induces breast cancer cell motility through STAT1-dependent ACTA2 induction. Oncotarget. 8:50570–50581. 2016.PubMed/NCBI

32 

Wu Y, Liu ZG, Shi MQ, Yu HZ, Jiang XY, Yang AH, Fu XS, Xu Y, Yang S, Ni H, et al: Identification of ACTG2 functions as a promoter gene in hepatocellular carcinoma cells migration and tumor metastasis. Biochem Biophys Res Commun. 491:537–544. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Pace-Asciak CR: Hepoxilins in cancer and inflammation-Use of hepoxilin antagonists. Cancer Metastasis Rev. 30:493–506. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Gagnaire A, Nadel B, Raoult D, Neefjes J and Gorvel JP: Collateral damage: Insights into bacterial mechanisms that predispose host cells to cancer. Nat Rev Microbiol. 15:109–128. 2017. View Article : Google Scholar : PubMed/NCBI

35 

McDermott AJ, Falkowski NR, McDonald RA, Frank CR, Pandit CR, Young VB and Huffnagle GB: Role of interferon-γ and inflammatory monocytes in driving colonic inflammation during acute clostridium difficile infection in mice. Immunology. 150:468–477. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Long AG, Lundsmith ET and Hamilton KE: Inflammation and colorectal cancer. Curr Colorectal Cancer Rep. 13:341–351. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Raskov H, Burcharth J and Pommergaard HC: Linking gut microbiota to colorectal cancer. J Cancer. 8:3378–3395. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M, Tilg H, Watson A and Wells JM: Intestinal permeability-A new target for disease prevention and therapy. BMC Gastroenterol. 14:1892014. View Article : Google Scholar : PubMed/NCBI

39 

Bultman SJ: Emerging roles of the microbiome in cancer. Carcinogenesis. 35:249–255. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Nieto MA, Huang RY, Jackson RA and Thiery JP: Emt: 2016. Cell. 166:21–45. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Fang Y, Zhang L, Li Z, Li Y, Huang C and Lu X: MicroRNAs in DNA damage response, carcinogenesis, and chemoresistance. Int Rev Cell Mol Biol. 333:1–49. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Kenneth NS and Rocha S: Regulation of gene expression by hypoxia. Biochem J. 414:19–29. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Ortmann B, Druker J and Rocha S: Cell cycle progression in response to oxygen levels. Cell Mol Life Sci. 71:3569–3582. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Wang H, Jiang H, Van De Gucht M and De Ridder M: Hypoxic radioresistance: Can ROS be the key to overcome it. Cancers (Basel). 11(pii): E1122019. View Article : Google Scholar : PubMed/NCBI

46 

Inokuma T, Haraguchi M, Fujita F, Torashima Y, Eguchi S and Kanematsu T: Suppression of reactive oxygen species develops lymph node metastasis in colorectal cancer. Hepatogastroenterology. 59:2480–2483. 2012.PubMed/NCBI

47 

Lin YC, Chen CC, Chen WM, Lu KY, Shen TL, Jou YC, Shen CH, Ohbayashi N, Kanaho Y, Huang YL and Lee H: LPA1/3 signaling mediates tumor lymphangiogenesis through promoting CRT expression in prostate cancer. Biochim Biophys Acta Mol Cell Biol Lipids. 1863:1305–1315. 2018. View Article : Google Scholar : PubMed/NCBI

48 

Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K and Possemato R: NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature. 551:639–643. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Lizarbe MA, Calle-Espinosa J, Fernandez-Lizarbe E, Fernandez-Lizarbe S, Robles MA, Olmo N and Turnay J: Colorectal cancer: From the genetic model to posttranscriptional regulation by noncoding RNAs. Biomed Res Int. 2017:73542602017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ju Q, Zhao YJ, Dong Y, Cheng C, Zhang S, Yang Y, Li P, Ge D and Sun B: Identification of a miRNA‑mRNA network associated with lymph node metastasis in colorectal cancer. Oncol Lett 18: 1179-1188, 2019.
APA
Ju, Q., Zhao, Y., Dong, Y., Cheng, C., Zhang, S., Yang, Y. ... Sun, B. (2019). Identification of a miRNA‑mRNA network associated with lymph node metastasis in colorectal cancer. Oncology Letters, 18, 1179-1188. https://doi.org/10.3892/ol.2019.10460
MLA
Ju, Q., Zhao, Y., Dong, Y., Cheng, C., Zhang, S., Yang, Y., Li, P., Ge, D., Sun, B."Identification of a miRNA‑mRNA network associated with lymph node metastasis in colorectal cancer". Oncology Letters 18.2 (2019): 1179-1188.
Chicago
Ju, Q., Zhao, Y., Dong, Y., Cheng, C., Zhang, S., Yang, Y., Li, P., Ge, D., Sun, B."Identification of a miRNA‑mRNA network associated with lymph node metastasis in colorectal cancer". Oncology Letters 18, no. 2 (2019): 1179-1188. https://doi.org/10.3892/ol.2019.10460
Copy and paste a formatted citation
x
Spandidos Publications style
Ju Q, Zhao YJ, Dong Y, Cheng C, Zhang S, Yang Y, Li P, Ge D and Sun B: Identification of a miRNA‑mRNA network associated with lymph node metastasis in colorectal cancer. Oncol Lett 18: 1179-1188, 2019.
APA
Ju, Q., Zhao, Y., Dong, Y., Cheng, C., Zhang, S., Yang, Y. ... Sun, B. (2019). Identification of a miRNA‑mRNA network associated with lymph node metastasis in colorectal cancer. Oncology Letters, 18, 1179-1188. https://doi.org/10.3892/ol.2019.10460
MLA
Ju, Q., Zhao, Y., Dong, Y., Cheng, C., Zhang, S., Yang, Y., Li, P., Ge, D., Sun, B."Identification of a miRNA‑mRNA network associated with lymph node metastasis in colorectal cancer". Oncology Letters 18.2 (2019): 1179-1188.
Chicago
Ju, Q., Zhao, Y., Dong, Y., Cheng, C., Zhang, S., Yang, Y., Li, P., Ge, D., Sun, B."Identification of a miRNA‑mRNA network associated with lymph node metastasis in colorectal cancer". Oncology Letters 18, no. 2 (2019): 1179-1188. https://doi.org/10.3892/ol.2019.10460
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